Protein Alignment Rdl and Glrb

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_445748.1
• Gene: Glrb / 25456
• RGDID: 2706
• Length: 496
• Species: Rattus norvegicus
• Alignment Length: 561
• Identity: 179/561 - (31%)
• Similarity: 256/561 - (45%)
• Gaps: 149/561 - (26%)

  Fly    60 SAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKR 124
            |.||:...||||.|:|||:.|.||:|.|.:::.|..|:.|..||:.::.:.||.|.||||   |.
  Rat    57 SNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRL---KL 118

  Fly   125 P----GVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASC 185
            |    |.:.|:|.....|.:|.||.||.|||.:.||..|..|..:.:...|.:..|:||:||.||
  Rat   119 PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSC 183

  Fly   186 PMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRV------LGHRQRA 244
            |::|..||||.|.|.:::||||||..|:|:.|:.| ..|.: .::.||||.:      .|:   .
  Rat   184 PLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSG-DPVQL-EKIALPQFDIKKEDIEYGN---C 243

  Fly   245 TEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLT 309
            |:....||.|:.:.......|.:|:|::.:|.|:.|||::||:|||:|.:|:.|||.||:.:||:
  Rat   244 TKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLS 308

  Fly   310 MTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYM---AKRIQMRKQRFMAIQKI 371
            :.:..::..|.|||:||||::||:|..|.:..||||:|||.|..|   .||::..|.|.
  Rat   309 LASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARI------ 367

  Fly   372 AEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAH 436
              .|.:|.||.....|..|   .|.|.|
  Rat   368 --AKAEQADGKGGNAAKKN---TVNGTG------------------------------------- 390

  Fly   437 SHGHPHAPKQTVSNRPIGFSNIQQNVGTRGC---------------SIVGPLFQEVRFKVHDPKA 486
                          .|:..|.:|  ||...|               ||||.|.::.....:|
  Rat   391 --------------TPVHISTLQ--VGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYD--- 436

  Fly   487 HSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKV 551
             ..|..:|  ||.|.|.||:....|                  ||.....|.||
  Rat   437 -CYGKPIE--VNNGLGKPQAKNKKP------------------PPAKPVIPTAA----------- 469

  Fly   552 KKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYL 592
                          ..||.|:|.:||.||:.||::||.|||
  Rat   470 --------------KRIDLYARALFPFCFLFFNVIYWSIYL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	69/192 (36%)
		Cys-loop	185..199	CDD:349809	8/13 (62%)
		Neur_chan_memb	274..588	CDD:460753	89/331 (27%)
Glrb	NP_445748.1	LIC	43..495	CDD:455710	176/558 (32%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	70/193 (36%)
		Cys-loop	183..197	CDD:349811	8/13 (62%)