DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rdl and Gabra3

DIOPT Version :9

Sequence 1:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_058765.3	Gene:	Gabra3 / 24947	RGDID:	2648	Length:	493	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	156/544 - (28%)
Similarity:	233/544 - (42%)	Gaps:	144/544 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 ILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPG 126
            |||.....||.|:||..|....||...:||.|...:|:..|::|:|.:|||.|.|.||.: ..|
  Rat    70 ILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKF-DGP- 132

  Fly   127 VETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQY 191
            ::.|.:.:.....||.|||||.|.|:|..|..||.|:.:|:..:|::..::||||.|.|||:|:.
  Rat   133 MKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLED 197

  Fly   192 FPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVE-------LPQFRVLGHRQRATEINL 249
            ||||...|.::..|:.||..::.|.|     ::|.:..||       |.|:.:|||......|..
  Rat   198 FPMDVHACPLKFGSYAYTKAEVIYSW-----TLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRS 257

  Fly   250 TTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLM 314
            :||.|..:.......|.:||::||.|:|..:.||:|.|||||||.:.|||...|||||||||||.
  Rat   258 STGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLS 322

  Fly   315 SSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQL 379
            .|...:|||::|..::|.::..|:..||::|:|:|||.|..||....:.:  .:.:..|.||:.
  Rat   323 ISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGK--KVPEALEMKKKT- 384

  Fly   380 DGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAP 444
                                                                         |.||
  Rat   385 -------------------------------------------------------------PAAP 388

  Fly   445 KQTVSNRPIGFSNIQQNVGTRGCSIVGP-----LFQEVRFKVHDPKAHSKGGTLENTVNGGRGGP 504
            .:..|..               .:|||.     |.::..|               :|::.....|
  Rat   389 TKKTSTT---------------FNIVGTTYPINLAKDTEF---------------STISKAAAAP 423

  Fly   505 QSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDID 569
            .:                     ...|.....|:......  .|.:.|....::|        :|
  Rat   424 SA---------------------SSTPTVIASPKTTYVQD--SPAETKTYNSVSK--------VD 457

  Fly   570 KYSRIVFPVCFVCFNLMYWIIYLH 593
            |.|||:|||.|..|||:||..|::
  Rat   458 KISRIIFPVLFAIFNLVYWATYVN 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	65/189 (34%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	74/318 (23%)
Gabra3	NP_058765.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..54
		LIC	69..479	CDD:273305	155/540 (29%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	71/205 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100