DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rdl and Gabrb3

DIOPT Version :9

Sequence 1:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_058761.2	Gene:	Gabrb3 / 24922	RGDID:	2651	Length:	473	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	182/544 - (33%)
Similarity:	271/544 - (49%)	Gaps:	116/544 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRK 123
            :...:|.....||.|:||::|||||.||:.:.:.||..:|||.||:||..||:|:|.|.||||..
  Rat    37 VKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSG 101

  Fly   124 RPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMN 188
            .|  ..|::.:.....:|||||:|:|:|:|:.|..|..|..||:|..|::...:|:|.||:|.|:
  Rat   102 IP--LNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMD 164

  Fly   189 LQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGN 253
            |:.:|:|.|.|.:||||:|||..||.::||.|..:|.....:|||||.::.||..:..:...||.
  Rat   165 LRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGA 229

  Fly   254 YSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTN 318
            |.||:...:..|::||:::|.|:||.||.|:||||||:|.:|:.||||||:||||||||:.:...
  Rat   230 YPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLR 294

  Fly   319 AALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGAN 383
            ..||||.|||:||:||..|||.||.:|||||.|.|:......::|:     |:||:..:..:..:
  Rat   295 ETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK-----KLAEKTAKAKNDRS 354

  Fly   384 QQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTV 448
            :.:.|                                             ...:||:       :
  Rat   355 KSEIN---------------------------------------------RVDAHGN-------I 367

  Fly   449 SNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPG-PG 512
            ...|:...|....|                       |.|.|.|..:.::....|.|..... |.
  Rat   368 LLAPMDVHNEMNEV-----------------------AGSVGDTRNSAISFDNSGIQYRKQSMPK 409

  Fly   513 QGGGPPGGGGGGGGGGGPPEGGGDPEAAVP---AHLLHPGKVKKVK-----DINKLLGITPSDID 569
            :|.|...|                 :.::|   .||.......|:|     |:|.        ||
  Rat   410 EGHGRYMG-----------------DRSIPHKKTHLRRRSSQLKIKIPDLTDVNA--------ID 449

  Fly   570 KYSRIVFPVCFVCFNLMYWIIYLH 593
            ::||||||..|..|||:||:.|::
  Rat   450 RWSRIVFPFTFSLFNLVYWLYYVN 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	75/182 (41%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	90/322 (28%)
Gabrb3	NP_058761.2	LIC	10..471	CDD:273305	181/540 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820