DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rdl and glra4b

DIOPT Version :9

Sequence 1:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001189440.1	Gene:	glra4b / 192125	ZFINID:	ZDB-GENE-020402-2	Length:	492	Species:	Danio rerio

Alignment Length:	528	Identity:	180/528 - (34%)
Similarity:	263/528 - (49%)	Gaps:	112/528 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 YDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGS 134
            ||.|:|||:.||||.|...:::.|..|::|..||:.|:.:.||.|.||||||::.|. ::|.:..
Zfish    57 YDARIRPNFKGPPVNVTCNIFINSFGSITETTMDYRLNVFLRQQWNDPRLAYKEYPD-DSLDLDP 120

  Fly   135 EFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLC 199
            ..:.:||.||.||.|||.:.||..||.|:.:|:..:|::..|||||:..||||:|:.||||.|.|
Zfish   121 SMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFQNGNVLYSIRLTLILSCPMDLKNFPMDTQTC 185

  Fly   200 HIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQF-----RVLGHRQRATEINLTTGNYSRLAC 259
            .:::|||||||.|:.:.|.|. ..|.::.::.||||     :.||:..:    :..||.::.:..
Zfish   186 TMQLESFGYTMNDLIFQWLDE-GPVQVADDLMLPQFVLKEEKDLGYCTK----HYNTGKFTCIEV 245

  Fly   260 EIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKI 324
            :....|.|||||||:||||.|.||:||||||:|.:|.||||.||:||||||||..|.:.|:|||:
Zfish   246 KFHLERQMGYYLIQMYIPSLLTVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKV 310

  Fly   325 SYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKI-AEQKKQQLDGANQQQAN 388
            ||||:||:::..|.:.|||:|||||.|.:::::.   |:.|...:|: .||:.:...|.......
Zfish   311 SYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQY---KEFFRLRRKLRQEQRNRAASGQAGAAET 372

  Fly   389 PNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPI 453
            .|.:.||.|                                         |.|....|
Zfish   373 KNKSNNVTG-----------------------------------------GTPSRNAQ------- 389

  Fly   454 GFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPP 518
                       |.||...   :|.:....:...:..|..::.:::|  .||.|..... ..|.||
Zfish   390 -----------RQCSACA---REEQLASQNQDLYFPGFGIDTSLSG--DGPLSEAAAM-FAGLPP 437

  Fly   519 GGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCF 583
            |                        |.|.        ||.:........||..||.|||:.|:.|
Zfish   438 G------------------------HALF--------DIRRRFVEQAKRIDTISRAVFPLSFLVF 470

  Fly   584 NLMYWIIY 591
            |:.||:.|
Zfish   471 NVFYWVTY 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	70/187 (37%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	90/314 (29%)
glra4b	NP_001189440.1	LIC	5..478	CDD:273305	179/526 (34%)
		Neur_chan_LBD	47..253	CDD:280998	80/201 (40%)
		Neur_chan_memb	260..475	CDD:280999	90/314 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810