Protein Alignment Rdl and lgc-40

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001407536.1
• Gene: lgc-40 / 188854
• WormBaseID: WBGene00020767
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 546
• Identity: 136/546 - (24%)
• Similarity: 232/546 - (42%)
• Gaps: 122/546 - (22%)

  Fly    70 YDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPG--VETLSV 132
            ||:.:|.:..|.|..|.::|::..:||.|...||:.||.||::.|.|.|||:.....  |..|:|
 Worm    53 YDEYIRVHGTGVPTNVTLSMFIEGMSSFSAQTMDYHLDVYFQEEWYDHRLAHNASAPILVRDLTV 117

  Fly   133 GSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQ 197
                .|.:|.||.:|.|.:.:.|...|..|..:.|:.:|.:....|::|.:||.|:|..:|:|.|
 Worm   118 ----FKMMWHPDVYFANARSAAFQDITDDNFLVWVYPNGRVWYDARISIVSSCNMDLWKYPLDSQ 178

  Fly   198 LCHIEIESFGYTMRDIRYFW--RDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGNYSRLACE 260
            .|.:.|.|:.|.|..:|..|  ::.:.::..:.::.:|...:...|.........||.:|.:...
 Worm   179 ECALRILSYAYPMTVLRLLWSEKEDVPAIDRNPDITMPDMSLKHIRTGYCNGTYATGEWSCMTAI 243

  Fly   261 IQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKIS 325
            ....|.|.::::|.|:|:.|||:|||.:|||..::.||||:|.:||:||::|..::...|||::|
 Worm   244 FYVEREMMHHVMQTYVPTALIVVISWFNFWLEIDSAPARVSLSITTLLTISTQANAVKLALPEVS 308

  Fly   326 YVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRK---QRFMAIQKIAEQ---KKQQLDGANQ 384
            |:|:|||::|:|...||..::|: |:.:.||.::|.:   |..:.:......   ..:.:|...:
 Worm   309 YMKAIDVWMGSCMAFVFGVMIEF-TICHYAKNLEMLRGDGQPSLIVDTALSTLFGAARDIDDLVR 372

  Fly   385 QQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAP--KQT 447
            :.|..|....|                               .|.|..|.|.:..:|..|  :..
 Worm   373 KVATLNEEEGV-------------------------------RGDGEQHIALNMLNPEEPRLRSL 406

  Fly   448 VSNRPIGFSNIQQNVGT------RGCSIVGPLFQEVRFKVH-----DPKAHSKGGTLENTVNGGR 501
            ..|..:..:..:..||.      |..:.:..|.|:|....|     ..:|.:....|.| :.|.|
 Worm   407 NQNNDVTANGTRYFVGAERMKRKRSKASLSRLRQQVASMRHATIDVSRRAFNWTRALRN-LRGRR 470

  Fly   502 GGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPS 566
                                                                          ...
 Worm   471 --------------------------------------------------------------VAQ 473

  Fly   567 DIDKYSRIVFPVCFVCFNLMYWIIYL 592
            .||:..|||||:.|:.||:.||..||
 Worm   474 RIDERCRIVFPMIFLLFNVAYWSFYL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	51/186 (27%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	73/332 (22%)
lgc-40	NP_001407536.1	LIC	31..498	CDD:455710	134/543 (25%)