Protein Alignment Rdl and unc-49

DIOPT Version :9

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001022785.1
• Gene: unc-49 / 176472
• WormBaseID: WBGene00006784
• Length: 506
• Species: Caenorhabditis elegans
• Alignment Length: 624
• Identity: 224/624 - (35%)
• Similarity: 316/624 - (50%)
• Gaps: 156/624 - (25%)

  Fly     9 LARMAPLPRTPLLTIWLAINMALIAQETGHKRIHTVQAATGGGSMLGDVN---ISAILDSFS--V 68
            :||  |.....||:..|.:::.:...|..|                  :|   :|::||..:  .
 Worm     1 MAR--PFTLIVLLSAHLCLHVVVTQDEDSH------------------INTQLLSSVLDRLTNRT 45

  Fly    69 SYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRK-----RPGVE 128
            :||||:||.||..||:||:|::|.|||::|||.||||||||.||.|.|||||:..     ...::
 Worm    46 TYDKRLRPRYGEKPVDVGITIHVSSISAVSEVDMDFTLDFYMRQTWQDPRLAFGSLDLGLSKEID 110

  Fly   129 TLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFP 193
            :|:||.:::..:|.|||||.|||:|:||:|||.|.|:|:...|::..|.|||:||:|||:|:.||
 Worm   111 SLTVGVDYLDRLWKPDTFFPNEKKSFFHLATTHNSFLRIEGDGTVYTSQRLTVTATCPMDLKLFP 175

  Fly   194 MDRQLCHIEIESFGYTMRDIRYFW---RDGLSSVGMSSEV-ELPQFRVLGHRQRATEINLTTGNY 254
            ||.|.|.:||||:||..:||.|:|   |..|....:..:. :||||:...:....|:...::|.|
 Worm   176 MDSQHCKLEIESYGYETKDIDYYWGKKRTDLEITAVKFDTFQLPQFQPTLYFVNTTKAETSSGKY 240

  Fly   255 SRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNA 319
            .|||.|:..||:||:|.:.|.|||.|||.||||||||||.|:||||.||||||||||||:::||.
 Worm   241 VRLALEVILVRNMGFYTMNIVIPSILIVTISWVSFWLNREASPARVGLGVTTVLTMTTLITTTNN 305

  Fly   320 ALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQ 384
            ::||:||||.:||:|..|||||||||||||.|.||.||:.:|:::         ::|    .|.|
 Worm   306 SMPKVSYVKGLDVFLNFCFVMVFASLLEYAIVSYMNKRLVLRREK---------RRK----AAEQ 357

  Fly   385 QQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHG-----------HGHGHHAHSH 438
            ||.|..|..|              ..|....|....|.:..::.           :..||::
 Worm   358 QQRNEMPMFN--------------ASPKAANNNSYEMTLMSQNSTPAKSYVQADLYFAGHNS--- 405

  Fly   439 GHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGG 503
                      |..|:  ..|.:|...|..    |:.|..|.                 |..|
 Worm   406 ----------SMNPL--MEIPENCDCRTI----PMMQHPRL-----------------VTDG--- 434

  Fly   504 PQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLL--GITPS 566
                                                   ||.|.|....:.|..:|..  ..||:
 Worm   435 ---------------------------------------AHTLWPAPFARPKKASKTCCQRWTPA 460

  Fly   567 DIDKYSRIVFPVCFVCFNLMYWI----IYLHVSDVVADD 601
            .|||.||..||:.|..||::||:    :.|:.||.:.::
 Worm   461 KIDKLSRYGFPLSFSIFNIVYWLYMKYLSLNSSDKIQEN 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	89/191 (47%)
		Neur_chan_memb	274..588	CDD:397193	105/326 (32%)
unc-49	NP_001022785.1	LIC	37..484	CDD:273305	211/551 (38%)
		Neur_chan_LBD	37..248	CDD:280998	99/210 (47%)
		Neur_chan_memb	260..482	CDD:280999	105/326 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166350
Domainoid	1	1.000	173	1.000	Domainoid score	I2227
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16893
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.880