DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rdl and gabrb1

DIOPT Version :9

Sequence 1:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_002664179.2	Gene:	gabrb1 / 100331377	ZFINID:	ZDB-GENE-090313-230	Length:	484	Species:	Danio rerio

Alignment Length:	553	Identity:	183/553 - (33%)
Similarity:	284/553 - (51%)	Gaps:	131/553 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRK 123
            :...:|.....||.|:||::|||||:||:::.:.||..:|||.||:|:..||:|.|.|.||:|..
Zfish    45 VKVTVDKLLKGYDIRLRPDFGGPPVDVGMSIDISSIDMVSEVNMDYTITMYFQQSWRDKRLSYTG 109

  Fly   124 RPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMN 188
            .|  ..|::.:.....:|||||:|:|:|:|:.|..|..|..||:|..|::...:|:|.||:|.|:
Zfish   110 IP--LNLTLDNRVADQLWVPDTYFINDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMD 172

  Fly   189 LQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGN 253
            |:.:|:|.|.|.:||||:|||..||.::|:.|.|..|:.: :|||||.::.::..:.::...||:
Zfish   173 LRRYPLDEQNCTLEIESYGYTTDDIEFYWQGGSSVTGVDN-IELPQFSIIDYKTLSKKVVFATGS 236

  Fly   254 YSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTN 318
            |.||:...:..|::||:::|.|:||.||.|:||||||:|.:|:.||||||:||||||||:.:...
Zfish   237 YPRLSLSFKLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTINTHLR 301

  Fly   319 AALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYM----AKRIQMRKQRFMAIQKIAEQKKQQL 379
            ..||||.|||:||:||..|||.||.:|||||.|.|:    ...:|         :|:||:..:..
Zfish   302 ETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGRGPHLQ---------KKVAEKAAKSN 357

  Fly   380 DGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAP 444
            :..::.::|.                         |.|.|                  ||
Zfish   358 NEKSRLESNK-------------------------VQVDV------------------HG----- 374

  Fly   445 KQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTV-NGGRGGPQSHG 508
                   .|..:|:...:.  |..::|.|        .||:         ||: :......|...
Zfish   375 -------SIPLTNLDLRLS--GAEMLGAL--------GDPR---------NTMFSYDSASIQYRK 413

  Fly   509 PGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVK--------KVK-----DINKL 560
            |..|:                  :..|.|.|::...|. |.|.:        |||     |:|.
Zfish   414 PLTGR------------------DLYGRPTASIERPLA-PKKSRLRRRAAQLKVKIPDLTDVNA- 458

  Fly   561 LGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLH 593
                   |||:||::||:.:..|||:||:.|:|
Zfish   459 -------IDKWSRVIFPITYTFFNLVYWLYYVH 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	71/182 (39%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	94/331 (28%)
gabrb1	XP_002664179.2	LIC	19..482	CDD:273305	181/549 (33%)
		Neur_chan_LBD	49..250	CDD:280998	82/203 (40%)
		Neur_chan_memb	257..479	CDD:280999	94/331 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720