Protein Alignment nwk and SRGAP3

DIOPT Version :10

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: XP_016863063.1
• Gene: SRGAP3 / 9901
• HGNCID: 19744
• Length: 1117
• Species: Homo sapiens
• Alignment Length: 1208
• Identity: 236/1208 - (19%)
• Similarity: 399/1208 - (33%)
• Gaps: 417/1208 - (34%)

  Fly    13 FLKNLHT---EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPD 74
            |.:.:.|   ||...|:.:::....||:|:::|..:::.:|..||.||.|::.:: :.||.:..:
Human    38 FRQEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERF-SSKIRSSRE 101

  Fly    75 IKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQ-------QQIADEAKVLRDYKLA--IA 130
            .:.:..:...:..:.|..||.:..:.:|......::|.       .||:::  |:|.:|.:  |.
Human   102 HQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISED--VIRLFKKSKEIG 164

  Fly   131 KRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQK 195
            .:....::.|..||:    .|.||...|..|...|.....:|...|||...|.|....::...:.
Human   165 LQMHEELLKVTNELY----TVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHED 225

  Fly   196 NSARVTSRK--ELLEEKSSG-----------ARNDYVLSLAAANAHQNRYFTVDLQ--------- 238
            ...|.:|.|  |.::||...           |||||:|:|||.||..::|:..|:.
Human   226 RPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLG 290

  Fly   239 ---TTMTTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYPVL 300
               :...|...|:   .|||.:...|.|.|  ...:|:...:..::.:.|  ....|..:|.|.|
Human   291 FHASLARTFRTYL---SAEYNLETSRHEGL--DVIENAVDNLDSRSDKHT--VMDMCNQVFCPPL 348

  Fly   301 KQHIQYDFEACDNDPVRKVTA------------------------EHESAAETLTKEAKNLAGRV 341
            |    ::|:....|.|.:|:|                        |:|...:||....:.|...:
Human   349 K----FEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDML 409

  Fly   342 VKENASIRENAKKLALCQSLRDSGQRTDPND------------------------PNGPDLDTKI 382
            ..|:..:.:..:.....:|::.:...|..:.                        .||.:|.||:
Human   410 TVEDFDVSDAFQHSRSTESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKL 474

  Fly   383 EEFRDQIRRSETEKTKAEA------CL--------------------------QCLRDGGINVDE 415
            :...|.::::..|..:||.      ||                          ..::|.|..:..
Human   475 QAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPL 539

  Fly   416 WVQEA---------ENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSD-------------- 457
            .|:..         :..|:..:..|...::...::..:||:|..|...:.|
Human   540 VVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRG 604

  Fly   458 -------KEETQAAAQT--------KPKQEQQL--SRDRT--------------FSDSEDEPEVR 491
                   ||..|....|        :..|.||:  :..|.              .|...||..:.
Human   605 LENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMD 669

  Fly   492 PSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDK-----DEPIVPEPKE----AIFKC 547
            |    .:.|.....::|....|  .||  |:..|...|..|     .|.|.|.|:|    ...||
Human   670 P----YNLAICFGPTLMHIPDG--QDP--VSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKC 726

  Fly   548 TALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDIDQETAGSAFNGT 612
            .|                                     .|||      |.|......|
Human   727 MA-------------------------------------GGEE------YCDSPHSEPG------ 742

  Fly   613 SGNQLRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDEL 677
                     :...||:....|..|.|     ::|..|.|            ||.:||...:..||
Human   743 ---------AIDEVDHDNGTEPHTSD-----EEVEQIEA------------IAKFDYMGRSPREL 781

  Fly   678 TFEEGDKIKIITKTAHGVDDGWWEGELDGKFGNFPS--LVVEECDE-MGEPLSEGGDESPPPTAA 739
            :|::|..:.:.    |...:.||||..:|..|..|.  :||::.|: ..:.||:..|..
Human   782 SFKKGASLLLY----HRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSE------ 836

  Fly   740 PTFALPPAPALPPEYAHELELELTEDMFGSQDTADEDSGYI-------PNGAAAPSIPPPVLIQE 797
                ....|.|..:.:.:.:|:..     ::..:|...|.:       .:|||.|.       :.
Human   837 ----ASSGPLLDDKASSKNDLQSP-----TEHISDYGFGGVMGRVRLRSDGAAIPR-------RR 885

  Fly   798 PGMEDDLSDDGQPP----PSLPPPQLAKAGGSAP-------GSGSKVEKG--AAAGGANTLN--- 846
            .|     .|...||    ||:..|..|.|..|:|       |.....||.  |..|.|.::|
Human   886 SG-----GDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESPEKRRMATFGSAGSINYPD 945

  Fly   847 ---------------------LG---------MAQ-IIVTAATPMVE------DGADKSFPPVGE 874
                                 ||         :|: |..|.:|.:.|      ....|..|.|..
Human   946 KKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVL 1010

  Fly   875 SDAQPVE----PVSKEQPAE-----VAKKPDIA-----------------------------PKP 901
            ...:|::    |||.| ||.     |.:.||.|                             |.|
Human  1011 DTLEPLKNPPGPVSSE-PASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPP 1074

  Fly   902 LAKVAP--QSAPAKEGNAGV-RPVVSITLTEYPSCDAE 936
            :..|.|  |...:...::|| .|.|:.|...:|:..|:
Human  1075 MRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMFPNSSAD 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:472257	70/301 (23%)
		SH3_FCHSD_1	545..600	CDD:212695	7/54 (13%)
		YgiM	<562..668	CDD:442337	16/105 (15%)
		SH3	663..718	CDD:473055	18/56 (32%)
		PRK12323	<725..956	CDD:481241	63/313 (20%)
SRGAP3	XP_016863063.1	F-BAR_srGAP3	44..296	CDD:153368	61/258 (24%)
		RhoGAP_srGAP	520..707	CDD:239848	31/194 (16%)
		SH3_srGAP1-3	766..818	CDD:212888	17/67 (25%)