Protein Alignment nwk and TRIP10

DIOPT Version :10

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: XP_006723003.1
• Gene: TRIP10 / 9322
• HGNCID: 12304
• Length: 649
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 115/641 - (17%)
• Similarity: 224/641 - (34%)
• Gaps: 195/641 - (30%)

  Fly    20 EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKK-IPNIPDIKMEGME-- 81
            :|...|:...|...|||:...:|..:|:.||::|::.|..:..:||.|: ..:.|:.|....:
Human     9 DQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQQSF 73

  Fly    82 ----ERWNMWSVWRTVLEEN-------------EKLARARLAAIEV---FQQQIADEAKVLRDYK 126
                :..|.::..|.::.||             :::.:.|....:.   .|||:.:..|.|.:.|
Human    74 VQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSK 138

  Fly   127 LAI------AKRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGS 185
            ...      |:::......:.::::.:..||:|.|:......|.|.:.:::.....::..:.:..
Human   139 RKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAH 203

  Fly   186 FF-----QSITSLQ----KNSARVTSRKELLEEKSSGARNDYVLSLA--------AANA---HQN 230
            |:     |....||    :.:.|:.:...||.|    |..:.|..:|        ||||   ..:
Human   204 FYFSQMPQIFDKLQDMDERRATRLGAGYGLLSE----AELEVVPIIAKCLEGMKVAANAVDPKND 264

  Fly   231 RYFTVDLQTTMTTMENYV-FERVAEYLMLMGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCCY 294
            .:..::|..:.......| ||   ::...|.|      :.:.:|.|...|...:|..
Human   265 SHVLIELHKSGFARPGDVEFE---DFSQPMNR------APSDSSLGTPSDGRPELRG-------- 312

  Fly   295 LFYPVLKQHIQYDF-------------------EACDN---------DPVRKVTAEHESAAETLT 331
               |...:..::.|                   .|..|         ||:..::...:|....|.
Human   313 ---PGRSRTKRWPFGKKNKPRPPPLSPLGGPVPSALPNGPPSPRSGRDPLAILSEISKSVKPRLA 374

  Fly   332 --KEAKNLAGRVVKENAS--------------IRENAKKL--------ALCQSLRDSGQRTDPND 372
              :..:...|.||.|:.|              :.|.:::|        || :.::|..::| |..
Human   375 SFRSLRGSRGTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREAL-KKMKDVYEKT-PQM 437

  Fly   373 PNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWVQEAENMGVQELTRSASSISM 437
            .:...|:.:|.|....|.|.:.|..|.||              |:.|||:   :.|:....|:|.
Human   438 GDPASLEPQIAETLSNIERLKLEVQKYEA--------------WLAEAES---RVLSNRGDSLSR 485

  Fly   438 RTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFSDSEDEPEVRPSAAAASSAAA 502
            .........:...||..:|..::|:.:::..|.:|.|
Human   486 HARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQ---------------------------- 522

  Fly   503 ASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKCTALYSYTAQNP 558
                         |.|....:    :||.::||..|     |..|.|:|.:....|
Human   523 -------------DTPIYTEF----DEDFEEEPTSP-----IGHCVAIYHFEDLGP 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:472257	59/310 (19%)
		SH3_FCHSD_1	545..600	CDD:212695	4/14 (29%)
		YgiM	<562..668	CDD:442337
		SH3	663..718	CDD:473055
		PRK12323	<725..956	CDD:481241
TRIP10	XP_006723003.1	F-BAR_CIP4-like	5..257	CDD:153337	47/251 (19%)
		HR1_CIP4_FNBP1L	395..475	CDD:212018	20/98 (20%)