DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nwk and FCHSD1

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_258260.1	Gene:	FCHSD1 / 89848	HGNCID:	25463	Length:	690	Species:	Homo sapiens

Alignment Length:	834	Identity:	215/834 - (25%)
Similarity:	353/834 - (42%)	Gaps:	173/834 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQPPPRKGNYVKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYL 65
            |||||||....:.:|....||::.||...|.|.|||||||.::.:|:|:|:.|.::|.|::.
Human     1 MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAG--- 62

  Fly    66 NKKIPNIPDIKMEG-----MEERW-NMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRD 124
                   |.:|.||     |:.|. .::..||.:|:......:.||.|.:.::.......   |.
Human    63 -------PFLKREGHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTG---RS 117

  Fly   125 YKLAIAKRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQS 189
            .|..:.::....:...|.|:..||.::.:::|.|...|......::||.|::.:|.:.....|.|
Human   118 AKEQVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIFHS 182

  Fly   190 ITSLQKNSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAE 254
            .|||||.|.:::::.....::...|||:|:|:|.|.|||.:.|:..:|...:..:.:.:.|.:.:
Human   183 RTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEHLRD 247

  Fly   255 YLMLMGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCCY----LFYPVLKQHIQYDFEACDNDP 315
            .|..:..|||...........:......|::.|.:|:...    :|.|...|  |:.....|...
Human   248 PLTSLSHTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSPTPPQ--QFQPAGTDQVC 310

  Fly   316 VRKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPNGPDLDT 380
            |.:..||..:....|.||.:.|..|..:: ..|:.:..:  :.|.|..  :|...::...|.::.
Human   311 VLEWGAEGVAGKSGLEKEVQRLTSRAARD-YKIQNHGHR--VLQRLEQ--RRQQASEREAPSIEQ 370

  Fly   381 KIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWVQ----EAENMGVQELTRSASSISMRTDA 441
            :::|.|:.|||::..:.|..|.|..|:..|::|:.|::    :|::...||...|.:.:|.| |.
Human   371 RLQEVRESIRRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQDEVEQERRLSEARLSQR-DL 434

  Fly   442 SGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSS 506
            |     |:::....||.||.:...:.                 .:||  .|.|.|..:
Human   435 S-----PTAEDAELSDFEECEETGEL-----------------FEEP--APQALATRA------- 468

  Fly   507 MMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKCTALYSYTAQNPDELTIVENEQLEV 571
                                          :|.|...:|:      |.|...|||||.|.|.|||
Human   469 ------------------------------LPCPAHVVFR------YQAGREDELTITEGEWLEV 497

  Fly   572 VGEGDGDGWLRARNYRGEEGYVPHNYLDIDQETAGSAFNGTSGNQLRSQISFSSVDYTVDNEDQT 636
            :.|||.|.|::|||..||.|:||..||:..                         |.::....|.
Human   498 IEEGDADEWVKARNQHGEVGFVPERYLNFP-------------------------DLSLPESSQD 537

  Fly   637 VDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIKIITKTAHGVDDGWWE 701
            .|:....:..:.:..             |||.|...:.:||:|.||..|:::.:...|||||:|.
Human   538 SDNPCGAEPTAFLAQ-------------ALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWR 589

  Fly   702 GELDGKFGNFPSLVVEEC------DEMGEPLSEGGDESPPPTA--APTFAL--PPAPALPPEYAH 756
            ||..|:.|.||||:|||.      .|:.:|.......|||..:  |||..|  ||||.||
Human   590 GEFGGRVGVFPSLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVLP----- 649

  Fly   757 ELELELTEDMFGSQDTADEDSGYIPNGA-----AAPSIPPPVLIQEPGMEDDLS 805
                         .|.|.:..|::...|     ..|..|||....:||..|.|:
Human   650 -------------GDKALDFPGFLDMMAPRLRPMRPPPPPPAKAPDPGHPDPLT 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	69/270 (26%)
		SH3_FCHSD_1	545..600	CDD:212695	28/54 (52%)
		SH3	663..718	CDD:354299	25/54 (46%)
		PRK12323	<725..956	CDD:237057	26/90 (29%)
FCHSD1	NP_258260.1	F-BAR_FCHSD1	16..275	CDD:153362	69/271 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..444		6/27 (22%)
		SH3_FCHSD_1	470..526	CDD:212695	30/61 (49%)
		SH3_FCHSD1_2	550..607	CDD:212828	26/69 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..690		26/98 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159298
Domainoid	1	1.000	59	1.000	Domainoid score	I10689
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	343	1.000	Inparanoid score	I2337
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52870
OrthoDB	1	1.010	-	-		D154524at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40452
orthoMCL	1	0.900	-	-		OOG6_105517
Panther	1	1.100	-	-	LDO	PTHR15735
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2901
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.770