DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nwk and BZZ1

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_011982.1	Gene:	BZZ1 / 856514	SGDID:	S000001156	Length:	633	Species:	Saccharomyces cerevisiae

Alignment Length:	748	Identity:	148/748 - (19%)
Similarity:	296/748 - (39%)	Gaps:	205/748 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKK----IP-NIPD--------IKMEGME 81
            |:....|:||.||..:|:.:||.|||.|.::|::|.|||    :| ::.|        |:..|:
Yeast    23 QNNLKWLKDIEQFYRERAKLEKDYSERLSRLSAEYFNKKSSTSVPISVGDTPTTTPGSIEAAGV- 86

  Fly    82 ERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQKELHL 146
                  ..|..:|.:.:.:::              |..::..|::..:|.: |:|:        .
Yeast    87 ------VAWNEILSQTDMISK--------------DHDQLSTDFENHVANQ-LSGL--------F 122

  Fly   147 SVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTS-----RKEL 206
            :..|:..:|.:.|:     :|:.:|..:|..:|:|.|..:.::.::::....|.|.     .|:.
Yeast   123 TKLDMTLSKINGFN-----NDMVNKKDNIYHELEKAKKDYDEACSTMEMARNRYTKASNDRNKKK 182

  Fly   207 LEEKS---SGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMGRTELLTCS 268
            |:||.   :..:|:|::.:..||..:::|:..|:...:..:::     |.|...|......|..:
Yeast   183 LDEKEMEMNKCKNEYLIKINQANRTKDKYYFQDVPEVLDLLQD-----VNEAKTLFLNDLWLKAA 242

  Fly   269 ATQNSFGKIRDQAQQLTREYNLQCCYLFYPVLKQH---------IQYDFEAC--DNDPVRK---V 319
            :.:|..|....:..|....           |:||:         |:::.:..  ..|.|.|   |
Yeast   243 SVENDLGANVSKRLQAANS-----------VVKQNKPSLNTAIFIKHNLKNWKEPQDFVYKPSPV 296

  Fly   320 TAEHESAAETLTKEAKNLAGRVVK-EN--ASIRENAK----KLALCQSLRDSGQRTDPNDPNGPD 377
            ..:.|..|...:.|.::|..::.| ||  .|:::..:    ||:....::.. .:|:.::.|...
Yeast   297 WHDDEKFAVPSSLEVEDLRIKLAKAENDYNSLQDKTQNELSKLSTLNKIKHE-MKTNEDNINATK 360

  Fly   378 LDTKIEEFRDQI---RRSETEKTKAEACLQCLRDGGINV-DEWVQEAENMGVQELTRSASSI--- 435
            ....::|:.:.:   ...||.|.:||..::.:::   || :|:....:|:.:.: |:..|.|
Yeast   361 FYDTLKEYLNVVSPFTSHETLKLQAEVQIESIQN---NVPEEYDLSTDNIDLSK-TKKKSGIFSK 421

  Fly   436 -------------SMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFSDSEDE 487
                         |..:..:|.|......|.:::.:.....:|.....::...:..||.|.:..:
Yeast   422 FKHNILNVDSKPSSGGSTGNGNGGPLHITSLFNTSRRTRLGSAPNNAGEDSDNNSIRTTSTNNTK 486

  Fly   488 PEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKCTALYS 552
            ...:.|:                                  :|.|::              .||:
Yeast   487 KTTQNSS----------------------------------DDGKNK--------------VLYA 503

  Fly   553 YTAQNPDELTIVENEQLEVVGEGDGDGWLRARN-YRGEEGYVPHNYLDIDQETAGSAFNGTSGNQ 616
            |..::.||:||...:::.:|....|.||.:..| ..||.|.||..|:.|....
Yeast   504 YVQKDDDEITITPGDKISLVARDTGSGWTKINNDTTGETGLVPTTYIRISSAA------------ 556

  Fly   617 LRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEE 681
                        ||...|:.    .:|:     :.|.:|....|....|:|.|:|..:||::.:.
Yeast   557 ------------TVKANDRG----PAPE-----VPPPRRSTLPVRTMEAIYAYEAQGDDEISIDP 600

  Fly   682 GDKIKIITKTAHGVD-DGWWEGELDGKFGNFPS 713
            ||.|.:|    .|.| .||..||.||..|.||:
Yeast   601 GDIITVI----RGDDGSGWTYGECDGLKGLFPT 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	56/271 (21%)
		SH3_FCHSD_1	545..600	CDD:212695	18/55 (33%)
		SH3	663..718	CDD:354299	21/52 (40%)
		PRK12323	<725..956	CDD:237057
BZZ1	NP_011982.1	BAR	10..256	CDD:416402	56/272 (21%)
		SH3_CIP4_Bzz1_like	497..552	CDD:212711	19/68 (28%)
		SH3_Bzz1_2	581..631	CDD:212712	21/53 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I1379
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15735
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.960