Protein Alignment nwk and SRGAP2B

DIOPT Version :9

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_001372155.1
• Gene: SRGAP2B / 647135
• HGNCID: 35237
• Length: 489
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 106/550 - (19%)
• Similarity: 196/550 - (35%)
• Gaps: 186/550 - (33%)

  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDI 75
            ||.::...|||:..|..:.:....||:|::.|..|::.:|..||.:|.|::.::|.|....
Human    21 VKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTCST---- 81

  Fly    76 KMEGMEERWNMWSV-------------------------------------WRTVLEENEKLARA 103
                .::::|.::|                                     |..:|.:.::.:|.
Human    82 ----KDQQFNAFTVIMSPADVQAACDFPGLLSTPESFPLRKDQNVLSPVNCWNLLLNQVKRESRD 142

  Fly   104 RLAAIEVF-------------------------QQQIADE-AKVLRDYKLAIAKRSLAGIVNVQK 142
            .....:::                         .||:.|: .|||.:            :.:|.|
Human   143 HTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNE------------LYSVMK 195

  Fly   143 ELHL----SVGDVDKTKKSYFDEE-HCAHDVRDKARD------------IEEKLKKKKGSFFQSI 190
            ..|:    |:....|.|::...|| .....|:.:.|.            ||||..::  |..:.|
Human   196 TYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRR--SSVKKI 258

  Fly   191 TSL-QKNSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTM------------- 241
            ..: :|..|:.|..|    .|:..|||:|:|:|.|.||...:|:..||...:
Human   259 EKMKEKRQAKYTENK----LKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLN 319

  Fly   242 TTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKI--RDQAQQLTREYNLQCCYLFYPVLKQHI 304
            ..:..::   .||..:...:.|.|  .|.:|:...:  ....|:|...||    .:|.|.:|
Human   320 RALRTFL---SAELNLEQSKHEGL--DAIENAVENLDATSDKQRLMEMYN----NVFCPPMK--- 372

  Fly   305 QYDFEACDNDPVRKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTD 369
             ::|:....|...::.|:....:|.|.:                         ||.|:..
Human   373 -FEFQPHMGDMASQLCAQQPVQSELLQR-------------------------CQQLQSR----- 406

  Fly   370 PNDPNGPDLDT-KIEEFRDQIRRSETEKTKAEACLQCLRD----GGINVDEWVQEAENMGVQELT 429
                    |.| |||       ..|.:|| .||.||.::|    ...:|.:..|.:.:|...:.|
Human   407 --------LSTLKIE-------NEEVKKT-MEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKST 455

  Fly   430 RSASSISMRTDASGQGENPSSDSFYDSDKE 459
            .|.:.:|..:.|..:.....::.||.:.:|
Human   456 VSETFMSKPSIAKRRANQQETEQFYFTVRE 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	66/360 (18%)
		SH3_FCHSD_1	545..600	CDD:212695
		SH3	663..718	CDD:354299
		PRK12323	<725..956	CDD:237057
SRGAP2B	NP_001372155.1	BAR	26..319	CDD:416402	60/318 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810