DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nwk and SRGAP1

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_065813.1	Gene:	SRGAP1 / 57522	HGNCID:	17382	Length:	1085	Species:	Homo sapiens

Alignment Length:	1157	Identity:	219/1157 - (18%)
Similarity:	398/1157 - (34%)	Gaps:	359/1157 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDI 75
            ||.::....||...|:.:.:....||:|::.|..|::.:|..||.:|.|::.::: .|..:..|.
Human    21 VKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFM-AKTRSTKDH 84

  Fly    76 KMEGMEERWNMWS---VWRTVLEE--NEKLARARLAAIEV------FQQQIADEAKVLRDYKLAI 129
            :....::  |:.|   .|..:|.:  .|....|.|:.|.:      |.|...|..::.:..| .|
Human    85 QQYKKDQ--NLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSK-EI 146

  Fly   130 A---KRSLAGIVN----VQKELHL----SVGDVDKTKKSYFDEE-----------HCAHDVRDKA 172
            |   ...|..::|    |.|..|:    |:....|.|::...||           |...:.|.:.
Human   147 AFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQR 211

  Fly   173 RDIEEKLKKKKGSFFQSITSLQKNSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDL 237
            |...:|::|.|          :|..|:.:..|    .||..|||:|:|:|.|.||...:|:..||
Human   212 RSSVKKIEKMK----------EKRQAKYSENK----LKSIKARNEYLLTLEATNASVFKYYIHDL 262

  Fly   238 QTTM------------TTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKI--RDQAQQLTREY 288
            ...:            ..:..|:   .|||.:...|.|.|  ...:|:...:  |...|:....|
Human   263 SDLIDCCDLGYHASLNRALRTYL---SAEYNLETSRHEGL--DIIENAVDNLEPRSDKQRFMEMY 322

  Fly   289 NLQCCYLFYPVLKQHIQYDFEACDNDPVRKVTAEHESAAETL----------------------T 331
            ....|    |.:|    ::|::...|.|.:|:|:....||.:                      |
Human   323 PAAFC----PPMK----FEFQSHMGDEVCQVSAQQPVQAELMLRYQQLQSRLATLKIENEEVKKT 379

  Fly   332 KEA--KNLAGRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPN-------------------- 374
            .||  :.:...|..|:..:.|..:.....:|::.:...|..:.|:
Human   380 TEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLR 444

  Fly   375 ----GPDLDTKIEEFRDQIRRSETEKTKA------------------------------------ 399
                |.:|.||::...|.::|:..|..:|
Human   445 EYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLE 509

  Fly   400 --------------EACLQCLRDGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSS 450
                          |:|::.:...|:         ::.|:..::.|...::...::..:||||.:
Human   510 TFVKDSGQVIPLIVESCIRFINLYGL---------QHQGIFRVSGSQVEVNDIKNSFERGENPLA 565

  Fly   451 DSFYDSDKEETQAAAQTK-----------PKQ--EQQLSRDRTFSDSEDEPEVRPSAAAASSAA- 501
            |.  .|:.:....|...|           ||:  ...:|..|..:..|....:|........:.
Human   566 DD--QSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVL 628

  Fly   502 -------AASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPI---VPEPKEAIFKCTALYSYTAQ 556
                   |..:.:...|.....||..:....|        |.   |||.::.: .|.|
Human   629 IVMRYLFAFLNHLSQYSDENMMDPYNLAICFG--------PTLMPVPEIQDQV-SCQA------- 677

  Fly   557 NPDEL--TIVENEQLEVVGEGDGDGWLRARNYRGEE----GYVPHNYL-DIDQETAGSAFNGTSG 614
            :.:|:  ||:.:.:.......:.||.:..:...|::    .|..|..| ::||:.      ||.
Human   678 HVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDA------GTE- 735

  Fly   615 NQLRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTF 679
                        .:|.::|.:.:::                        ||.:||...:..||:|
Human   736 ------------PHTSEDECEPIEA------------------------IAKFDYVGRSARELSF 764

  Fly   680 EEGDKIKIITKTAHGVDDGWWEGELDGKFGNFPS--LVVEECDE-MGEPLSEGGDESPPPTAAPT 741
            ::|..:.:.    |...:.||||..:|..|..|.  :||::.|: ..:.||:..|..  .::.|
Human   765 KKGASLLLY----HRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSE--ASSGP- 822

  Fly   742 FALPPAPALPPEYAHELELELTEDMFGSQD----TADEDSGYIPNGAAAPSIPPPVLIQEPGMED 802
                                :|||...|:|    |.....||:.........||||  :.||.
Human   823 --------------------VTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPPV--RRPGR-- 863

  Fly   803 DLSDDGQPPPSLPPPQLAKAGGSAPGSGS-----------------KVEKGAAAGGANTLNLGMA 850
              :.||..|  |.||..........||.|                 ..|:....|..:..|:...
Human   864 --TSDGHCP--LHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRH 924

  Fly   851 QIIVTAATPMVEDGADKSFPPVGESDAQPVEPVSKEQPAE-----------------VAK-KPDI 897
            ..:....:|.:. .:..|....|.:|.:|::|.:..|..|                 .|| .||:
Human   925 DSLKKIDSPPIR-RSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDV 988

  Fly   898 APKPLAKVAPQSAPAKEGNAGVRPVVSITLTEYPSCDAEDQQSFSEGTDSAS 949
            ....|.:|.....|| .....:.|:.::.|.   |.:.:.::|.|..:|:.|
Human   989 VLDTLEQVKNSPTPA-TSTESLSPLHNVALR---SSEPQIRRSTSSSSDTMS 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	71/311 (23%)
		SH3_FCHSD_1	545..600	CDD:212695	11/61 (18%)
		SH3	663..718	CDD:354299	18/56 (32%)
		PRK12323	<725..956	CDD:237057	53/264 (20%)
SRGAP1	NP_065813.1	F-BAR_srGAP1	26..278	CDD:153367	62/269 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..496		0/20 (0%)
		RhoGAP_srGAP	502..689	CDD:239848	33/213 (15%)
		SH3_srGAP1-3	747..799	CDD:212888	16/79 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	808..954		35/177 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	997..1038		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1051..1085
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810