DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nwk and LOC562049

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	XP_021324662.1	Gene:	LOC562049 / 562049	-ID:	-	Length:	689	Species:	Danio rerio

Alignment Length:	730	Identity:	144/730 - (19%)
Similarity:	251/730 - (34%)	Gaps:	228/730 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKME 78
            :|.|.::|...|:...|...|.:|...:|..:||.:|.:|:..:..:|.:|..||       |.|
Zfish    48 MKMLSSDQFDNLEKHTQWGIDFVEKYTKFVKERSEIELNYARQMRNLSKKYQPKK-------KDE 105

  Fly    79 GMEERWNMWSVWRTVLEE-NEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQK 142
            . |.::.....:.:.|.| |:...:..:.|..:..|.||:..:..::.|   .:|........:.
Zfish   106 D-ENKYTWCRAFHSTLNELNDYAGQHEVIAENMMSQIIAELTRYSQEIK---TERKTHFHDGRKA 166

  Fly   143 ELHLSVG--DVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTSRKE 205
            :.|:..|  .::..|:.:  |..|..  .|:|:...||:...     .::|......||  .:.:
Zfish   167 QQHIEAGWKQLESCKRKF--ERDCKE--ADRAQQYFEKMDAD-----INVTKADVEKAR--QQAQ 220

  Fly   206 LLEEKSSGARNDYVLSLAAANAHQN-RYFTV--DLQTTMTTMENYVFERVAEYL----------- 256
            :..:.:|.::::|...|...|..|| .|:|:  ::...:..||....||:.|.|
Zfish   221 MRHQMASDSKSEYSSYLQKFNQEQNEHYYTIIPNIFQKIQAMEEKRIERMGESLKTFAEVDRQIL 285

  Fly   257 -----MLMGRTELL-------------------------------------TCSATQ--NSFGKI 277
                 .|.|.|:..                                     |.|.|.  ||..:.
Zfish   286 PIIGKCLDGMTQAAESIESKTDSSQVIESYKSGFEPPGDVEFEDYGQAMKRTVSETSLTNSRSEN 350

  Fly   278 RDQAQQLTREYNLQCCYLFYPVLKQHIQYDFEACDNDPVRK-----------VTAEHESAAET-- 329
            :.:....::...|      :|.:|::   ...:....||.:           ||.:...|.:|
Zfish   351 KPERSSKSKSKTL------WPFIKKN---KLMSLLTSPVPRQPPPDPPSPSAVTPDPCPAPQTPK 406

  Fly   330 ----------------------LTKEAKNLAGRVVKENASIR-----------------ENAKKL 355
                                  |....:.|:.:::..||.:|                 :..|||
Zfish   407 QCKEPLSHRFNDLMTSKPRMQCLRSLRRGLSLKLLSLNAHVRNLIEGSNPEDFSHLPPEQRRKKL 471

  Fly   356 -------------------ALCQSLRDSGQRTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEA 401
                               ||.:......:.....|||  .:|.::.|....|.:.:.|..|.|.
Zfish   472 QAKIDDINKDIQKEMDQRDALTKMKEVYIKNPQMGDPN--SVDPRLAEIAHNIEKLQVEAQKFEG 534

  Fly   402 CLQCLRDGGINVDEWVQEAE-NMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAA 465
                          |:.|.| .|.|:..|...:|....|    |...|.:::....|:|.:...:
Zfish   535 --------------WLAEVEGRMPVKSDTSRRTSTVYET----QNSTPPTNNNCAQDRESSPDGS 581

  Fly   466 QT-KPKQEQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEE 529
            .| :|..|.|.|         :|.:|:|..|.                            :|:|.
Zfish   582 YTEEPSSEVQTS---------NESKVQPETAE----------------------------SGDEF 609

  Fly   530 DDKDEPIVPEPKEAIFKCTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVP 594
            ||.:|.::|    .|..|.|||.:...|...:.|.|.|.|.|:.|..||||.|.|....||||||
Zfish   610 DDAEEDMLP----TIGTCKALYPFEGHNEGTIAITEGELLYVIEEDKGDGWTRVRRNEEEEGYVP 670

  Fly   595 HNYLDI--DQETAGS 607
            .:|:::  |....|:
Zfish   671 TSYVEVFLDSNAKGA 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	61/325 (19%)
		SH3_FCHSD_1	545..600	CDD:212695	24/54 (44%)
		SH3	663..718	CDD:354299
		PRK12323	<725..956	CDD:237057
LOC562049	XP_021324662.1	BAR	54..300	CDD:325158	55/267 (21%)
		HR1	464..540	CDD:320753	16/91 (18%)
		SH3	621..677	CDD:327375	24/55 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010