DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nwk and srgap3

DIOPT Version :9

Sequence 1:NP_001286994.1 Gene:nwk / 39052 FlyBaseID:FBgn0263456 Length:1075 Species:Drosophila melanogaster
Sequence 2:XP_005166172.1 Gene:srgap3 / 561567 ZFINID:ZDB-GENE-060524-4 Length:1094 Species:Danio rerio


Alignment Length:1184 Identity:234/1184 - (19%)
Similarity:393/1184 - (33%) Gaps:330/1184 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDI 75
            ||.::|...||...|:.:::....||:|:::|..:::.::..||.||.|::.::.:         
Zfish    21 VKEIRNQLVEQFKCLEQQSEARIQLLQDLQEFFRRKAEIQLEYSRSLEKLAERFSS--------- 76

  Fly    76 KMEGMEERWNMWS---VWRTVLEENEKLARARLAAIEVF-QQQIADEAKVLRDYKLAIAKRSLAG 136
            |:.|..:..::.|   .|..||.:..:.:|......::: ...|...|::..|......|....|
Zfish    77 KIRGPRKEQHLLSSVNCWYLVLNQTRRESRDHATLNDIYINNVIVRLAQISEDVIRLFKKSKEIG 141

  Fly   137 I------VNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQK 195
            |      |.|..||:    .|.||...|..|...|......|...|||...|.|....::...:.
Zfish   142 IQMHEELVKVTNELY----TVMKTYHMYHTESISAESKLKDAEKQEEKQFSKSGDLNVNLLRHED 202

  Fly   196 NSARVTS-RK-ELLEEKSSG-----------ARNDYVLSLAAANAHQNRYFTVDLQ--------- 238
            ...|.:| || |.::||...           |||||:|:|||.||...:|:..|:.         
Zfish   203 RPQRRSSVRKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAVVAKYYIHDVSDMIDCCDLG 267

  Fly   239 ---TTMTTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKI--RDQAQQLTREYNLQCC----Y 294
               :...|:..|:   .|||.:...|.|.|  ...:|:...:  |....::...||...|    :
Zfish   268 YHASLARTLRTYL---SAEYNLETSRHEGL--DIIENAVDNLDPRSDKHKIMDMYNQVFCPPMRF 327

  Fly   295 LFYPVL---------KQHIQYDF-------------EACDNDPVRK------------VTAE--- 322
            .|.|.:         :|.:|.:.             ...:|:.|||            :|.|   
Zfish   328 EFLPHMGDEVCQVSAQQPVQTELLMRFHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFD 392

  Fly   323 ------HESAAETLTKEAK-------NLAGRVVKE------------------NASIRENAKKLA 356
                  |..:.|::...|.       |:|.|...:                  |..|:..||...
Zfish   393 VSDAFQHSRSTESIKSVASESYMSKLNIAKRRANQQETEVFYFTKFKEYLNGSNLIIKLQAKHDL 457

  Fly   357 LCQSLRDSGQRTDPNDPNGPDLDTKIEEFRDQIRRS-------------------ETEKTKAEAC 402
            |.|:|.: |:|.:......|.|..|.::.|....||                   :......|:|
Zfish   458 LKQTLGE-GERAECGTTRPPTLPPKPQKLRKPRPRSVYNHKLFNGNMESFIKDSGQAIPLVVESC 521

  Fly   403 LQCLRDGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQT 467
            ::.:...|:         :..|:..:..|...::...::..:||:|..|.  .||.:....|...
Zfish   522 IRYINLYGL---------QQQGIFRVPGSQVEVNDIKNSFERGEDPLVDD--QSDHDINSVAGVL 575

  Fly   468 K-----------PKQEQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEV 521
            |           ||:.        |.|                  ..|:..:.|||         
Zfish   576 KLYFRGLENPLFPKER--------FLD------------------MISTVKLESSA--------- 605

  Fly   522 NWGAGEEEDDKDEPIVPEPKEAIFKCTALYS-------YTAQN---PDELTIVENEQLEVVGEGD 576
                 |......:.||..|:..|.....|::       |:.:|   |..|.|.....|..:.:|.
Zfish   606 -----ERAHHIQQIIVTLPRTVIIVLRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPIPDGQ 665

  Fly   577 GDGWLRARNYRGEEGYVPHNYL--DIDQETAGSAFNG--TSGNQLRSQISFSSVDYTVDNEDQTV 637
            .....:|......:..:.||.:  ...:|..|..:..  |.|.:...  |..|...|:|..|...
Zfish   666 DPVACQAHVNEVIKTIIMHNEIIFPSPRELDGPVYEKCMTGGEEYCD--SPHSEPGTIDEADNCT 728

  Fly   638 DSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIKIITKTAHGVDDGWWEG 702
            :...|.|:|..|.|            ||.:||......||:|::|..:.:.    |...:.||||
Zfish   729 EPHTSDDEVEQIEA------------IAKFDYMGRTPRELSFKKGASLLLY----HRASEDWWEG 777

  Fly   703 ELDGKFGNFPS--LVVEECDE-MGEPLSEGGD-------------------ESP-PPTAAPTFA- 743
            ..:|..|..|.  :||::.|: ..:.||:..|                   .|| .|:|...|: 
Zfish   778 RHNGVDGLIPHQYIVVQDLDDAFSDSLSQKADSEASSGPLLDDKASSKNDLHSPCEPSADYNFSG 842

  Fly   744 -------LPPAPALPPEYAHELELELTEDMFGSQDTADEDSGYIPNGAAAPSIPPPVLIQEPGME 801
                   .....|:|...:.      |:.....:||.       |..||.||.|..|.:....:|
Zfish   843 VMGRVRLRSDGSAIPRRRSG------TDSHSPPRDTP-------PRAAACPSSPHKVAVNRSHIE 894

  Fly   802 D--------------------DLSDDGQPPPSLPPPQLAKAGGSAPGSGSKVEKGAAAGG-ANTL 845
            .                    .:..:|.|...:|    .....|:.|....:|..|.|.. ..|:
Zfish   895 SPEKRRLGTFGSAGSINYPERKIYPEGHPLRPVP----GATRHSSLGDHKSLEAEALAEDIEKTM 955

  Fly   846 NLGMAQI-------IVTAATPMVEDGADKSFPPVGESDAQPVEPVSKEQPAEVAKKPDIAPKPLA 903
            |..:.::       ....|..:|.|..:....||....|.|:..:....|....::...:...:.
Zfish   956 NTALHELRELERQNTAKQAPDVVLDTLEPLKNPVSSEPASPLHTIMIRDPDAALRRSSSSTSEMM 1020

  Fly   904 KVAPQSAPAKEGNAGVRPVVSITLTEYPSCDAEDQQSFSEGTDSASVADVPVLQDAE-----DPF 963
            .....:..|:...|.:||.....:...|:      |..|..:.|:.|.. |.:...|     :|.
Zfish  1021 TTFKPALSARLAGAQLRPPPMRPVRPPPT------QHRSSSSSSSGVGS-PAITPTEKIFPNNPS 1078

  Fly   964 NEKA-KGESGDGSG 976
            |..| ...||:..|
Zfish  1079 NAAASSANSGEKPG 1092

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nwkNP_001286994.1 BAR 16..281 CDD:353336 72/301 (24%)
SH3_FCHSD_1 545..600 CDD:212695 11/66 (17%)
SH3 663..718 CDD:354299 18/56 (32%)
PRK12323 <725..956 CDD:237057 49/286 (17%)
srgap3XP_005166172.1 BAR 26..273 CDD:299863 62/259 (24%)
RhoGAP_srGAP 497..684 CDD:239848 35/237 (15%)
SH3_srGAP1-3 741..793 CDD:212888 17/67 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.