DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nwk and fnbp1a

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	XP_009302058.1	Gene:	fnbp1a / 558990	ZFINID:	ZDB-GENE-081105-105	Length:	641	Species:	Danio rerio

Alignment Length:	723	Identity:	134/723 - (18%)
Similarity:	235/723 - (32%)	Gaps:	254/723 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKMEGMEERW 84
            :|...|:...|...:.||...:|..:||.:|.||::.:..:|.:|         .:|....||..
Zfish    26 DQFDNLEKHTQWGIEFLERYTKFVKERSEIELSYAKQIRNLSKKY---------QLKKNSKEEEE 81

  Fly    85 NMWSVWR----TVLEENEKLARARLAAIEVFQQQIAD------EAKVLRDYKLAIAKRSLAGIVN 139
            ..::..|    |:.|.|:...:..:.|..:..|.||:      |.|..|.......:|:...|.|
Zfish    82 YKYTTCRAFLMTLNELNDYAGQHEVIAENLSSQIIAELSRYTQELKAERKSHFHDGRRAQQHIEN 146

  Fly   140 VQKELHLSVGDVDKTKKS------YFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSA 198
            ..|:|..|....::..|.      |||:...  |:.....|:|::...|           .|..|
Zfish   147 SWKQLESSKRRFERDCKEADRAQHYFDKMDA--DINVTKADVEKRCSLK-----------AKQQA 198

  Fly   199 RVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAE--------- 254
            ::  |.::.|:    ::|:|:..|...|..|:.::        .|:..::|:|:.|
Zfish   199 QM--RHQIAED----SKNEYLTYLQKFNKDQHEHY--------YTLIPHIFQRIQEMEERRVGRV 249

  Fly   255 -----------------------------------------------------------YLMLMG 260
                                                                       |.:.|.
Zfish   250 RESMRVYTEVERKVLPIVSKCLDGMTKAAESVEPKMDSKQVVESYKSGFEPPGDVDFEDYSVSMK 314

  Fly   261 RTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYPVLKQHIQYDFEACDNDP---------- 315
            |      :.:::||...|.::::.:|.       ..:|:||::......|....|
Zfish   315 R------AVSESSFLNARGESRRRSRS-------KLWPLLKRNKLMSLLASPRQPPPPPPTSPSP 366

  Fly   316 --VRKVTAEHESAAETLTKEAKNLAG--------RVVKENASIR--------------ENAKKL- 355
              ::......:...|.|::...:..|        |.:|...|::              :..|||
Zfish   367 DGLQNGPQSPQQPKEPLSQRLNDFMGTKHKMHCLRSLKRGLSLKLGTGQEDYSHLPPEQRRKKLQ 431

  Fly   356 -ALCQSLRDSGQRTDPNDP--------------NGPD-LDTKIEEFRDQIRRSETEKTKAEACLQ 404
             .|....:|..:..|..|.              ..|| :|.::||....:.:.:.|..|.|.
Zfish   432 AKLNDVNKDIQKEMDQRDALTKMKDVYIKNPHLGDPDSIDPRLEEITQSLEKLQFEAHKYEG--- 493

  Fly   405 CLRDGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKP 469
                       |:.|.|...:::.:.|....|...|:  ||..|.::: |..::|....:....|
Zfish   494 -----------WLTEVERKLLEKGSESQRRQSSHFDS--QGNTPLTNN-YGQNRESPDGSYTEDP 544

  Fly   470 KQEQQL---SRDRTFSDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDD 531
            ..|..:   ||...|.|..||
Zfish   545 STENTMQFKSRSTEFDDEFDE-------------------------------------------- 565

  Fly   532 KDEPIVPEPKEAIFKCTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHN 596
                  .||...|..|.|||.:..||...:::.|.|.|.|:.|..||||.|.|....||||||.:
Zfish   566 ------EEPLPTIGTCKALYPFEGQNEGTISMAEGEMLYVIEEDKGDGWTRVRRNEDEEGYVPTS 624

  Fly   597 YLDIDQET 604
            |:.:..:|
Zfish   625 YIKLFLDT 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	60/344 (17%)
		SH3_FCHSD_1	545..600	CDD:212695	24/54 (44%)
		SH3	663..718	CDD:354299
		PRK12323	<725..956	CDD:237057
fnbp1a	XP_009302058.1	F-BAR_FBP17	22..279	CDD:153360	54/288 (19%)
		HR1_FBP17	423..499	CDD:212019	17/89 (19%)
		SH3_FBP17	573..629	CDD:213004	24/55 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820