Protein Alignment nwk and srgap1b

DIOPT Version :9

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: XP_005164640.1
• Gene: srgap1b / 555788
• ZFINID: ZDB-GENE-041210-103
• Length: 1071
• Species: Danio rerio
• Alignment Length: 1202
• Identity: 211/1202 - (17%)
• Similarity: 389/1202 - (32%)
• Gaps: 389/1202 - (32%)

  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDI 75
            ||.:::...||...|:.:......||:|::.|..|::.:|..||.:|.|::.::: .|..:..|.
Zfish    21 VKEIRSQLVEQQKCLEQQTDMRVQLLQDLQDFFRKKAEIESEYSRNLEKLAERFM-AKTRSTKDH 84

  Fly    76 KMEGMEERWNMWS---VWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGI 137
            :....::  |:.|   .|..:|.:..:.::......:::...:......:.:..:.:.|:|...|
Zfish    85 QQYKKDQ--NLLSPVNCWYLLLNQVRRESKDHATLSDLYLNNVITRFTHVSEDNMRLLKKSKEII 147

  Fly   138 VNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLK------KKKGSFFQSITSL--- 193
            ..:|::|...:.::....|:|       |....:....|.|||      :::|...:::.||
Zfish   148 FQLQEDLMKILNELYTVMKTY-------HMYHTETLSAENKLKEAERQGERQGRGGEAVFSLRTE 205

  Fly   194 ----QKNSAR-VTSRKELLEEKSS-------GARNDYVLSLAAANAHQNRYFTVDLQTTMTTMEN 246
                ::|:|| :...||..:.|.|       .|||:|:|:|.|.||...:|:..||
Zfish   206 DRHQRRNAARKIQKMKEKRQAKYSENKLKVMKARNEYLLTLEATNASLFKYYIHDL--------- 261

  Fly   247 YVFERVAEYLMLMGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCC-YLFYPVLKQHIQ----- 305
                           :.|..|.......|..|.....|:.||:|:.. :....:|:..::
Zfish   262 ---------------SHLTDCCDLGYHAGLSRALRTYLSAEYSLETSRHEGLDILEGAVEGLDPG 311

  Fly   306 -------------------YDFEACDNDPVRKVTAEHESAAETL--------------------- 330
                               :.|:....|.|.::||..:..||.|
Zfish   312 NDRQRFMETHPTSFTPPTRFTFQPHMGDQVSQITALPQVQAELLLRFQQLQSRLSTLKIENEEVK 376

  Fly   331 -TKEA--KNLAGRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPN------------------ 374
             |.||  ..:...|..|:..:.|:.:.....:|::.|...|..:.|:
Zfish   377 KTSEATLSTIQDMVNMEDYDVSESFQHSRSTESVKSSVSDTYLSKPSLAKRRANQQETELFYFTK 441

  Fly   375 ------GPDLDTKIEEFRDQIRRSETEKTKA--------------------------EACLQCLR 407
                  |.:|..|::...|.::||..|..:|                          |:|::.:.
Zfish   442 LKEYLEGSNLIAKLQAKHDMLKRSIAEGYRADIMTTSRRRNSHSRNQDSGKAIPLIVESCIRFIN 506

  Fly   408 DGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSD--------------- 457
            ..|:         ::.|:..::.|...::...::..:|.:|.:|...:.|
Zfish   507 LYGL---------QHQGIFRVSGSQVEVNDIKNSFERGNDPLTDEENNHDINSVAGVLKMYFRNL 562

  Fly   458 ------KEETQ---AAAQTKPKQEQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSSMMASSAG 513
                  ||:..   |..:|:...|:.||..:..:...     ||:........|..:.:...|..
Zfish   563 DNPIFPKEKFNDLIACVRTESLYERALSIRKILTTMP-----RPTLVLMRYLFAFLNHLSQYSDE 622

  Fly   514 GWDDP------------------TEVNWGAGEEEDDK-----DEPIVPEPKE----AIFKCTALY 551
            ...||                  .:|:..|...|..|     .|.|.|:.||    ...||.:..
Zfish   623 NMMDPGNLAICFGPTLMPTPDLLDQVSCQAHVNEIVKTIIIHHETIFPDTKELEGPVYEKCMSNT 687

  Fly   552 SYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDIDQETAGSAFNGTSGNQ 616
            .|......|....|        ||:.||                               ||
Zfish   688 EYCESPYSEPGAFE--------EGEQDG-------------------------------GT---- 709

  Fly   617 LRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEE 681
                            |.||.:....|                || .||.:||...:..||||::
Zfish   710 ----------------ETQTSEEEGEP----------------VE-AIAKFDYVGRSGRELTFKK 741

  Fly   682 GDKIKIITKTAHGVDDGWWEGELDGKFGNFPS--LVVEECDEMGEPLSEGGDESPPPTAAP---- 740
            |..:.:..:.:    :.||||..:|..|..|.  :.::|.:.|.:.||:..|.....|.:.
Zfish   742 GSTLLLFQRAS----EDWWEGRHNGTDGLIPHQYVTLQEDEAMSDTLSQKTDSEASTTPSDEVSS 802

  Fly   741 --TFALPPAPALPPEYAHELELELTEDMFGSQDTADEDSGYIPNGAAAPSIPPPVLI-------- 795
              :...|..|.:|..:... ..:.||.:.........|:....||....|  |||.:
Zfish   803 RRSLTSPTEPRIPETFISR-HRKRTEALLRRVPGRLSDNHCHGNGLERSS--PPVTVTVTGHFSP 864

  Fly   796 -----------------QEPGM--------------EDDLSDDGQPPPSLPPPQLAKAGGSAPGS 829
                             :.||:              .:.|..:.:.||....|.....|.....|
Zfish   865 RELLRGNSCALDSPEHHRRPGLNGSSNGNITSSISRHESLRRERESPPIRQSPSALHCGLPIQRS 929

  Fly   830 GSKVEKGAAAGGANTLNLGMAQII-------VTAATPMVEDGAD--KSFP--PVGESDAQPVEPV 883
            .:......|.....|::|.:.::.       .|||..:|.|..:  ||.|  |.|.:.:....|.
Zfish   930 QTLNPHTMAQDIEETMSLALNELRELERQNGKTAAPDLVLDTLEQVKSSPSCPSGSTPSSLSSPS 994

  Fly   884 SKEQP-AEVAKKPDIAPKPLAKVAPQSAPAKEGNAGVRPVVS----ITLTEYPSCDAEDQQSFSE 943
            ....| :.::..|.:.|.|    .|.|....:..|..:|:.|    :||.. |:...:.
Zfish   995 DSPSPLSPISPLPPLPPLP----GPSSRRTNDLVATFKPIASPRMGVTLRP-PALRPKP------ 1048

  Fly   944 GTDSASVADVPVLQDAEDPFNEKAKGESGDGS 975
                      |:|..|..|.:::.:.....|:
Zfish  1049 ----------PILPKANPPPSQQPQNPDKSGT 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	57/288 (20%)
		SH3_FCHSD_1	545..600	CDD:212695	9/54 (17%)
		SH3	663..718	CDD:354299	16/56 (29%)
		PRK12323	<725..956	CDD:237057	51/291 (18%)
srgap1b	XP_005164640.1	BAR	26..277	CDD:299863	56/284 (20%)
		RhoGAP_srGAP	480..664	CDD:239848	26/197 (13%)
		SH3	722..772	CDD:302595	17/54 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810