DRSC/TRiP Functional Genomics Resources

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Protein Alignment nwk and FNBP1L

DIOPT Version :9

Sequence 1:NP_001286994.1 Gene:nwk / 39052 FlyBaseID:FBgn0263456 Length:1075 Species:Drosophila melanogaster
Sequence 2:NP_001157945.1 Gene:FNBP1L / 54874 HGNCID:20851 Length:605 Species:Homo sapiens


Alignment Length:713 Identity:134/713 - (18%)
Similarity:233/713 - (32%) Gaps:241/713 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKMEGMEERW 84
            :|...|....|...|.||...:|..:|..:|::|::.|..:..:|..|:       ..:..|.|:
Human     9 DQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKR-------SSKDEEPRF 66

  Fly    85 NMWSVWRTVLEE-NEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQKELHLSV 148
            .....:..:|.| |:...:..:.|.|:..:...:..:...|.|             .::::||..
Human    67 TSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLK-------------TERKMHLQE 118

  Fly   149 G------------DVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVT 201
            |            .:|.:||.:  |..|..  .:||:...|:|.....:   :...::|...::.
Human   119 GRKAQQYLDMCWKQMDNSKKKF--ERECRE--AEKAQQSYERLDNDTNA---TKADVEKAKQQLN 176

  Fly   202 SRKELLEEKSSGARNDYVLSLAAANAHQNRYFTV------------DLQTTMTTMENY------- 247
            .|..:.:|.    :|:|...|...|..|:::|.|            |.:.|:...|.|       
Human   177 LRTHMADEN----KNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSE 237

  Fly   248 -----VFERVAEYLMLMGR-------TELL------------------------------TCSAT 270
                 :..:..|.::|..:       ::::                              |.||:
Human   238 RKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTISAS 302

  Fly   271 QNSFGKI--------------------RDQAQQLTREYNLQCCYLF---YPVLKQHIQYDFEA-- 310
            :...||:                    :.|:..||.      ..||   .|...|.:.:..|.  
Human   303 KQESGKMDAKTTVGKAKGKLWLFGKKPKPQSPPLTP------TSLFTSSTPNGSQFLTFSIEPVH 361

  Fly   311 -CDND------------------PVRKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLA 356
             |.|:                  .|:...|..:.:.....:..|.|..|:.:.|..:::.:.:..
Human   362 YCMNEIKTGKPRIPSFRSLKRGWSVKMGPALEDFSHLPPEQRRKKLQQRIDELNRELQKESDQKD 426

  Fly   357 LCQSLRD----SGQRTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWV 417
            ....::|    :.|..||.     .|..|:.|..:.|.|...|..|.||              |:
Human   427 ALNKMKDVYEKNPQMGDPG-----SLQPKLAETMNNIDRLRMEIHKNEA--------------WL 472

  Fly   418 QEAE-NMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTF 481
            .|.| ..|.:...|.:|.|:....   ||......|:.|...:|.:.       ..||......|
Human   473 SEVEGKTGGRGDRRHSSDINHLVT---QGRESPEGSYTDDANQEVRG-------PPQQHGHHNEF 527

  Fly   482 SDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFK 546
            .|                                           |.|||       :|..||..
Human   528 DD-------------------------------------------EFEDD-------DPLPAIGH 542

  Fly   547 CTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDI--DQETAGS 607
            |.|:|.:...|...|.:.|.|.|.::.|..||||.|||...|||||||.:|:|:  ::.:.||
Human   543 CKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTLEKNSKGS 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nwkNP_001286994.1 BAR 16..281 CDD:353336 55/354 (16%)
SH3_FCHSD_1 545..600 CDD:212695 24/54 (44%)
SH3 663..718 CDD:354299
PRK12323 <725..956 CDD:237057
FNBP1LNP_001157945.1 F-BAR_FNBP1L 5..256 CDD:153359 50/277 (18%)
Interaction with CDC42 245..535 56/374 (15%)
HR1_CIP4_FNBP1L 399..479 CDD:212018 20/98 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..539 19/122 (16%)
Interaction with DNM1. /evidence=ECO:0000269|PubMed:16326391 522..605 34/132 (26%)
Interaction with DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000269|PubMed:16630611 541..605 25/63 (40%)
Interaction with DNM2 and WASL. /evidence=ECO:0000269|PubMed:16418535 541..597 25/55 (45%)
SH3_FNBP1L 541..597 CDD:213005 25/55 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D348563at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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