Protein Alignment nwk and FNBP1L

DIOPT Version :10

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_001157945.1
• Gene: FNBP1L / 54874
• HGNCID: 20851
• Length: 605
• Species: Homo sapiens
• Alignment Length: 713
• Identity: 134/713 - (18%)
• Similarity: 233/713 - (32%)
• Gaps: 241/713 - (33%)

  Fly    20 EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKMEGMEERW 84
            :|...|....|...|.||...:|..:|..:|::|::.|..:..:|..|:       ..:..|.|:
Human     9 DQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKR-------SSKDEEPRF 66

  Fly    85 NMWSVWRTVLEE-NEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQKELHLSV 148
            .....:..:|.| |:...:..:.|.|:..:...:..:...|.|             .::::||..
Human    67 TSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLK-------------TERKMHLQE 118

  Fly   149 G------------DVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVT 201
            |            .:|.:||.:  |..|..  .:||:...|:|.....:   :...::|...::.
Human   119 GRKAQQYLDMCWKQMDNSKKKF--ERECRE--AEKAQQSYERLDNDTNA---TKADVEKAKQQLN 176

  Fly   202 SRKELLEEKSSGARNDYVLSLAAANAHQNRYFTV------------DLQTTMTTMENY------- 247
            .|..:.:|.    :|:|...|...|..|:::|.|            |.:.|:...|.|
Human   177 LRTHMADEN----KNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSE 237

  Fly   248 -----VFERVAEYLMLMGR-------TELL------------------------------TCSAT 270
                 :..:..|.::|..:       ::::                              |.||:
Human   238 RKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTISAS 302

  Fly   271 QNSFGKI--------------------RDQAQQLTREYNLQCCYLF---YPVLKQHIQYDFEA-- 310
            :...||:                    :.|:..||.      ..||   .|...|.:.:..|.
Human   303 KQESGKMDAKTTVGKAKGKLWLFGKKPKPQSPPLTP------TSLFTSSTPNGSQFLTFSIEPVH 361

  Fly   311 -CDND------------------PVRKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLA 356
             |.|:                  .|:...|..:.:.....:..|.|..|:.:.|..:::.:.:..
Human   362 YCMNEIKTGKPRIPSFRSLKRGWSVKMGPALEDFSHLPPEQRRKKLQQRIDELNRELQKESDQKD 426

  Fly   357 LCQSLRD----SGQRTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWV 417
            ....::|    :.|..||.     .|..|:.|..:.|.|...|..|.||              |:
Human   427 ALNKMKDVYEKNPQMGDPG-----SLQPKLAETMNNIDRLRMEIHKNEA--------------WL 472

  Fly   418 QEAE-NMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTF 481
            .|.| ..|.:...|.:|.|:....   ||......|:.|...:|.:.       ..||......|
Human   473 SEVEGKTGGRGDRRHSSDINHLVT---QGRESPEGSYTDDANQEVRG-------PPQQHGHHNEF 527

  Fly   482 SDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFK 546
            .|                                           |.|||       :|..||..
Human   528 DD-------------------------------------------EFEDD-------DPLPAIGH 542

  Fly   547 CTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDI--DQETAGS 607
            |.|:|.:...|...|.:.|.|.|.::.|..||||.|||...|||||||.:|:|:  ::.:.||
Human   543 CKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTLEKNSKGS 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:472257	55/354 (16%)
		SH3_FCHSD_1	545..600	CDD:212695	24/54 (44%)
		YgiM	<562..668	CDD:442337	22/48 (46%)
		SH3	663..718	CDD:473055
		PRK12323	<725..956	CDD:481241
FNBP1L	NP_001157945.1	F-BAR_FNBP1L	5..256	CDD:153359	50/277 (18%)
		Interaction with CDC42	245..535		56/374 (15%)
		HR1_CIP4_FNBP1L	399..479	CDD:212018	20/98 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..539		19/122 (16%)
		Interaction with DNM1. /evidence=ECO:0000269|PubMed:16326391	522..605		34/132 (26%)
		Interaction with DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000269|PubMed:16630611	541..605		25/63 (40%)
		Interaction with DNM2 and WASL. /evidence=ECO:0000269|PubMed:16418535	541..597		25/55 (45%)
		SH3_FNBP1L	541..597	CDD:213005	25/55 (45%)