Protein Alignment nwk and arhgap4a

DIOPT Version :10

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_956738.2
• Gene: arhgap4a / 393416
• ZFINID: ZDB-GENE-040426-1229
• Length: 917
• Species: Danio rerio
• Alignment Length: 945
• Identity: 190/945 - (20%)
• Similarity: 350/945 - (37%)
• Gaps: 217/945 - (22%)

  Fly     8 GNYVKFLKNLHTEQVAKLQL---KNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKI 69
            |:|...:|.:..:...:|::   :.:.:..:.:|:..:..:|..:|..|:.||.|:..::.::
Zfish    15 GDYDTQIKEVRLQLAEQLRIFDGQVEQKTQVFQDMVDYLRRRGEIEGEYARSLDKLCDKFSSR-- 77

  Fly    70 PNIPDIKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSL 134
                ..|.|...:  ::.:.|:.:|.:..:.:|......:.:...:..:.....::...:||||.
Zfish    78 ----TKKKESSHQ--SVVNCWQVLLAQTRQESRDHSILSDSYSNILPQQLSHCIEHAQRLAKRSR 136

  Fly   135 A-------GIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITS 192
            .       |::.|..|||.::    ||...|:.|...|.....:|..:|||.|:......:  ..
Zfish   137 EICTLLQDGLLKVTIELHTTL----KTYYQYYTEFLSAEGKLKEAVKLEEKQKQSASKKME--RQ 195

  Fly   193 LQKNSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYL- 256
            ::|...:|    :.::.|.:.|||||:|:||||||..|:|:..||.|.:...:....:.:::.|
Zfish   196 IEKRQCKV----QEIQLKCTKARNDYLLNLAAANACMNKYYLQDLSTLIDCCDLGYHQSISKVLH 256

  Fly   257 ------------MLMGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYPVLKQHIQYDFE 309
                        :..|..:|.| :.::.|..:.||...|..   |...|.        .:::.:.
Zfish   257 FYLSSRQWAQQNLSTGMRQLET-TVSELSQSQDRDTLMQFN---NSAFCL--------PLRFQYH 309

  Fly   310 ACDNDPVRKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQ-SLRDS------GQR 367
            ..:.|.|.:|:|:.|..:|.:|: .:.|..|:......:.|:.|.|...| |:.:|      |..
Zfish   310 PYEGDQVVEVSAKCEMMSELVTR-VQQLQSRLSSVTLEVEESGKLLQSAQSSILESLAEIAFGST 373

  Fly   368 TD----PNDPNG------------------PDLD----TKIEEFRDQIRRSETEKTKAEACLQCL 406
            .|    |:.|.|                  ||.:    ||:   ||.:..|.. ::|.||....|
Zfish   374 PDFPSSPSSPEGNSDVSANKNFTLKRRASLPDAESLYFTKV---RDHLCNSSL-RSKLEAKHDLL 434

  Fly   407 RDGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQ 471
            :..       :|:||:..... ||:.|..|:|...|..|...:...|........||:.|..|..
Zfish   435 KVA-------IQKAESFDGNH-TRTRSKRSVRHKKSNPGSQINQKLFNGDLLSYIQASGQLIPAV 491

  Fly   472 EQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKD--- 533
            .:...|....:....|...|    ...|....:....|...|  |||..      :|..|.|
Zfish   492 VESCIRFINLNGLHHEGLFR----VPGSQMVVNQLKDAFEKG--DDPLT------DERCDMDSVA 544

  Fly   534 -----------EPIVPEPK-EAIFKC----------TALYSYTAQNPDELTIVEN---EQLEVVG 573
                       :|:.||.. :.:.:|          |.|....:..|..|.||..   ..|..|.
Zfish   545 GVLKLYFRGLEKPLFPEDSYDQLMECGQIDDETKKVTQLKLIVSSYPPSLIIVMRYLFAFLHHVS 609

  Fly   574 EGDGDGWLRARN---------YRGEEGYVPHN--------------YLDIDQETAGSAFNGTSGN 615
            :...:..::..|         .||     |:|              .:.|..|:...:.|...|.
Zfish   610 QYSDENMMQPYNLAVCFGPSLVRG-----PNNGDAAELQRINALVKSIIIQHESIFPSQNELPGP 669

  Fly   616 QLRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFE 680
            .....::....|.....|:...:|    :||.:     |..|.::: .:||:||...:..||:|:
Zfish   670 VYEKCMTLEEDDCEAVAEEGDGES----EQVQI-----KEPKDELQ-ALALFDYIGRSSTELSFK 724

  Fly   681 EGDKIKIITKTAHGVDDGWWEGELDGKFGNFPSLVVEECDEMGEPLSEGGDESPPPTAAPTFALP 745
            .||:..:.:|.:    ..||:||::|..|..|:..:..     :.:..|.|:....|...:..
Zfish   725 HGDRFIVYSKAS----SDWWKGEVNGSKGLIPNKYISV-----QSVDGGQDQKGKETLKSSCG-- 778

  Fly   746 PAPALPPEYAHELELELTED----MFGSQDTADEDSGYIPNGAAAPSIPPPVLIQEPGMEDDLSD 806
                     .|:.|.|:..:    :..:.|.|......:.:|.....:|....||
Zfish   779 ---------RHQTEEEVKAEKSTRLKVTTDKAGVGPSQVTSGKICLQLPTGQFIQ---------- 824

  Fly   807 DGQPPPSLP---PPQLAKA---GGSAPGSGSKVEK 835
            .|..|.:|.   .||:.::   |||.....:.|:|
Zfish   825 PGNSPGALRKTLDPQMRRSTTEGGSREECSTDVDK 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:472257	59/287 (21%)
		SH3_FCHSD_1	545..600	CDD:212695	14/90 (16%)
		YgiM	<562..668	CDD:442337	22/131 (17%)
		SH3	663..718	CDD:473055	17/54 (31%)
		PRK12323	<725..956	CDD:481241	22/121 (18%)
arhgap4a	NP_956738.2	None