DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nwk and arhgap4a

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_956738.1	Gene:	arhgap4a / 393416	ZFINID:	ZDB-GENE-040426-1229	Length:	917	Species:	Danio rerio

Alignment Length:	959	Identity:	197/959 - (20%)
Similarity:	354/959 - (36%)	Gaps:	245/959 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GNYVKFLKNLHTEQVAKLQL---KNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKI 69
            |:|...:|.:..:...:|::   :.:.:..:.:|:..:..:|..:|..|:.||.|:..::.::
Zfish    15 GDYDTQIKEVRLQLAEQLRIFDGQVEQKTQVFQDMVDYLRRRGEIEGEYARSLDKLCDKFSSR-- 77

  Fly    70 PNIPDIKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSL 134
                ..|.|...:  ::.:.|:.:|.:..:.:|......:.:...:..:.....::...:||||.
Zfish    78 ----TKKKESSHQ--SVVNCWQVLLAQTRQESRDHSILSDSYSNILPQQLSHCIEHAQRLAKRSR 136

  Fly   135 A-------GIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITS 192
            .       |::.|..|||.::    ||...|:.|...|.....:|..:|||.|:......:  ..
Zfish   137 EICTLLQDGLLKVTIELHTTL----KTYYQYYTEFLSAEGKLKEAVKLEEKQKQSASKKME--RQ 195

  Fly   193 LQKNSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYL- 256
            ::|...:|    :.::.|.:.|||||:|:||||||..|:|:..||.|.:...:....:.:::.|
Zfish   196 IEKRQCKV----QEIQLKCTKARNDYLLNLAAANACMNKYYLQDLSTLIDCCDLGYHQSISKVLH 256

  Fly   257 ------------MLMGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYPVLKQHIQYDFE 309
                        :..|..:|.| :.::.|..:.||...|..   |...|.        .:::.:.
Zfish   257 FYLSSRQWAQQNLSTGMRQLET-TVSELSQSQDRDTLMQFN---NSAFCL--------PLRFQYH 309

  Fly   310 ACDNDPVRKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQ-SLRDS------GQR 367
            ..:.|.|.:|:|:.|..:|.:|: .:.|..|:......:.|:.|.|...| |:.:|      |..
Zfish   310 PYEGDQVVEVSAKCEMMSELVTR-VQQLQSRLSSVTLEVEESGKLLQSAQSSILESLAEIAFGST 373

  Fly   368 TD----PNDPNG------------------PDLD----TKIEEFRDQIRRSETEKTKAEACLQCL 406
            .|    |:.|.|                  ||.:    ||:   ||.:..|.. ::|.||....|
Zfish   374 PDFPSSPSSPEGNSDVSANKNFTLKRRASLPDAESLYFTKV---RDHLCNSSL-RSKLEAKHDLL 434

  Fly   407 RDGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQ 471
            :..       :|:||:..... ||:.|..|:|...|..|...:...|........||:.|..|..
Zfish   435 KVA-------IQKAESFDGNH-TRTRSKRSVRHKKSNPGSQINQKLFNGDLLSYIQASGQLIPAV 491

  Fly   472 EQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKD--- 533
            .:...|....:....|...|    ...|....:....|...|  |||..      :|..|.|
Zfish   492 VESCIRFINLNGLHHEGLFR----VPGSQMVVNQLKDAFEKG--DDPLT------DERCDMDSVA 544

  Fly   534 -----------EPIVPEPK-EAIFKC----------TALYSYTAQNPDELTIVEN---EQLEVVG 573
                       :|:.||.. :.:.:|          |.|....:..|..|.||..   ..|..|.
Zfish   545 GVLKLYFRGLEKPLFPEDSYDQLMECGQIDDETKKVTQLKLIVSSYPPSLIIVMRYLFAFLHHVS 609

  Fly   574 EGDGDGWLRARN---------YRGEEGYVPHNYLDIDQETAGSAFNGTSGNQL------RSQISF 623
            :...:..::..|         .||     |:|         |.|......|.|      |.:..|
Zfish   610 QYSDENMMQPYNLAVCFGPSLVRG-----PNN---------GDAAELQRINALVKSIIIRHESIF 660

  Fly   624 SSVD----------YTVDNEDQTVDSMQ---SPDQVSVIMAPQKRVKSDVEWCIALYDYDATAED 675
            .|..          .|::.:|....:.:   ..:||.:     |..|.::: .:||:||...:..
Zfish   661 PSQSELPGPVYEKCMTLEEDDCEAVAEEGDGESEQVQI-----KEPKDELQ-ALALFDYIGRSST 719

  Fly   676 ELTFEEGDKIKIITKTAHGVDDGWWEGELDGKFGNFPSLVVEECDEMGEPLSEGGDESPPPTAAP 740
            ||:|:.||:..:.:|.:    ..||:||::|..|..|:..:..     :.:..|.|:....|...
Zfish   720 ELSFKHGDRFIVYSKAS----SDWWKGEVNGSKGLIPNKYISV-----QSVDGGQDQKGKETLKS 775

  Fly   741 TFALPPAPALPPEYAHELE----------LELTEDMFG---SQDTADEDSGYIPNGAAAPSIPPP 792
            :..           .|:.|          |::|.|..|   ||.|:.:.|..:|.|.
Zfish   776 SCG-----------RHQTEEEVKAEKSTRLKVTTDKAGVGPSQVTSGKISLQLPTGQ-------- 821

  Fly   793 VLIQEPGMEDDLSDDGQPPPSLP---PPQLAKA---GGSAPGSGSKVEK 835
             .||          .|..|.:|.   .||:.::   |||.....:.|:|
Zfish   822 -FIQ----------PGNSPGALRKTLDPQMRRSTTEGGSREECSTDVDK 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	59/287 (21%)
		SH3_FCHSD_1	545..600	CDD:212695	14/76 (18%)
		SH3	663..718	CDD:354299	17/54 (31%)
		PRK12323	<725..956	CDD:237057	27/130 (21%)
arhgap4a	NP_956738.1	F-BAR_srGAP	27..252	CDD:153340	52/242 (21%)
		RhoGAP_srGAP	471..655	CDD:239848	38/209 (18%)
		SH3_srGAP4	704..758	CDD:212889	17/58 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810