DRSC/TRiP Functional Genomics Resources

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Protein Alignment nwk and ARHGAP4

DIOPT Version :9

Sequence 1:NP_001286994.1 Gene:nwk / 39052 FlyBaseID:FBgn0263456 Length:1075 Species:Drosophila melanogaster
Sequence 2:NP_001158213.1 Gene:ARHGAP4 / 393 HGNCID:674 Length:986 Species:Homo sapiens


Alignment Length:1083 Identity:187/1083 - (17%)
Similarity:341/1083 - (31%) Gaps:384/1083 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLN--------- 66
            ||.::...:||:..|:|:.:...:||:::.:|..:|:.||..||..|.|::.::.:         
Human    21 VKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSR 85

  Fly    67 -----KKIPNIPDIKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYK 126
                 :|.|::           .:....|..:|:...:.:|...|..||....:|.....:.:..
Human    86 EHQSFRKEPSL-----------LSPLHCWAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDV 139

  Fly   127 LAIAKRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSIT 191
            ..:.|:|......:|.||...|.::...||:|......:.:...|.|:.|.:.:|:.|....:.|
Human   140 GRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTT 204

  Fly   192 S-------LQKNSARVTSRKELLEE---------------------------------------- 209
            :       |:|:|.:...|  |:|:                                        
Human   205 AGATEAGPLRKSSLKKGGR--LVEKLWPPQRPVAASSCAPVCWLQAGFLVHPPWWGAMCAPSTHQ 267

  Fly   210 ----------KSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMGRTEL 264
                      |.:.|||:|:||||:.||..:.|:..|:...|...:......:.:.|......|.
Human   268 RQAKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAES 332

  Fly   265 LTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYP------VLKQH-------IQYDFEACDNDPV 316
            .|.::.....|.:.:..:.|.            |      ||:.|       :::|:...|.|.|
Human   333 RTQASQVQGLGSLEEAVEALD------------PPGDKAKVLEVHATVFCPPLRFDYHPHDGDEV 385

  Fly   317 RKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPNGPDLDTK 381
            .::..|.|...|.|.: |:|:..|                                     ||  
Human   386 AEICVEMELRDEILPR-AQNIQSR-------------------------------------LD-- 410

  Fly   382 IEEFRDQIRRSETEKTKAEACLQCL-----RDGGINVDEWVQEAENMGVQELTRSASSISMRTDA 441
                |..|...|..|| .:|.||.|     .|.|..:|.:   ..:...:.|..::|....|...
Human   411 ----RQTIETEEVNKT-LKATLQALLEVVASDDGDVLDSF---QTSPSTESLKSTSSDPGSRQAG 467

  Fly   442 SGQGENPSSDSFY-----------------DSDKEETQAAAQTKPKQEQQLS----RDRTFSDSE 485
            ..:|:...:::||                 .:..|:.|.|.|...|:||::|    ..|.|..|.
Human   468 RRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQYTQRKFQKSR 532

  Fly   486 DEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPE----------- 539
               :.|||:................|:|                  :..|:|.|           
Human   533 ---QPRPSSQYNQRLFGGDMEKFIQSSG------------------QPVPLVVESCIRFINLNGL 576

  Fly   540 PKEAIFK-------------------------CTA-----------LYSYTAQN---PDEL--TI 563
            ..|.||:                         |||           ||..:.:.   |.:|  .:
Human   577 QHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGEL 641

  Fly   564 VENEQLEVVGEGDGDGWLRARN----------------------------YRGEEGYVPHNY--- 597
            :.:.:||...|       |..:                            |..|....|:|.   
Human   642 LASSELEATAE-------RVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVC 699

  Fly   598 ---------------------------LDIDQETAGSAFNGTSGNQLRSQISFSSVDYTVDNEDQ 635
                                       |.:..:..........|......::..|.....|.:.:
Human   700 FGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGDAQLE 764

  Fly   636 TVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIKIITKTAHGVDDGWW 700
            ::.:...|:..:.:.|.:..::..|| .:|.:.|......||:|..||.:::..:.:    ..||
Human   765 SLGADNEPELEAEMPAQEDDLEGVVE-AVACFAYTGRTAQELSFRRGDVLRLHERAS----SDWW 824

  Fly   701 EGELDGKFGNFPSLVV-----EECDEMGEPLSEGGDES--------------PPPTAAPTFALPP 746
            .||.:|..|..|...:     .|...:|..|...|:..              |.|..:|. |:.|
Human   825 RGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPCTSPE-AMGP 888

  Fly   747 A--------PALPPEYAHELELELTEDMFGSQDTADED--------SGYIPNGAAAPSIPPPVLI 795
            :        ||.|.::. |::..:.::|    |:..::        .|..|....:|| |.|   
Human   889 SGHRRRCLVPASPEQHV-EVDKAVAQNM----DSVFKELLGKTSVRQGLGPASTTSPS-PGP--- 944

  Fly   796 QEPGMEDDLSDDGQPPPSLPPPQLAKAGGSAPGSGSKVEKGAA 838
                         :.|.:.|..:|.:..|.:.|.|:.....|:
Human   945 -------------RSPKAPPSSRLGRNKGFSRGPGAPASPSAS 974

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nwkNP_001286994.1 BAR 16..281 CDD:353336 62/335 (19%)
SH3_FCHSD_1 545..600 CDD:212695 17/153 (11%)
SH3 663..718 CDD:354299 14/59 (24%)
PRK12323 <725..956 CDD:237057 26/144 (18%)
ARHGAP4NP_001158213.1 F-BAR_srGAP 26..321 CDD:153340 58/307 (19%)
LRS4 391..>512 CDD:255978 31/168 (18%)
RhoGAP 543..730 CDD:295372 24/211 (11%)
SH3_srGAP4 788..842 CDD:212889 16/58 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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