Protein Alignment nwk and Srgap2

DIOPT Version :9

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: XP_006249844.1
• Gene: Srgap2 / 360840
• RGDID: 1566016
• Length: 1071
• Species: Rattus norvegicus
• Alignment Length: 1168
• Identity: 231/1168 - (19%)
• Similarity: 388/1168 - (33%)
• Gaps: 376/1168 - (32%)

  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDI 75
            ||.::...|||:..|..:.:....||:|::.|..|::.:|..||.:|.|::.::|.|    ....
  Rat    21 VKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAK----TRST 81

  Fly    76 KMEGMEERWNMWS---VWRTVLEENEKLARARLAAIEVF-------------------------Q 112
            |.:..::..|:.|   .|..:|.:.::.:|......:::                         .
  Rat    82 KDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVG 146

  Fly   113 QQIADE-AKVLRDYKLAIAKRSLAGIVNVQKELHL----SVGDVDKTKKSYFDEE-HCAHDVRDK 171
            ||:.|: .|||.:            :.:|.|..|:    |:....|.|::...|| .....|:.:
  Rat   147 QQLQDDLMKVLNE------------LYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQE 199

  Fly   172 ARD------------IEEKLKKKKGSFFQSITSL-QKNSARVTSRKELLEEKSSGARNDYVLSLA 223
            .|.            ||||..::  |..:.|..: :|..|:.|..|    .|:..|||:|:|:|.
  Rat   200 DRQTPRSPDSTANVRIEEKHVRR--SSVKKIEKMKEKRQAKYTENK----LKAIKARNEYLLALE 258

  Fly   224 AANAHQNRYFTVDLQTTM-------------TTMENYVFERVAEYLMLMGRTELLTCSATQNSFG 275
            |.||...:|:..||...:             ..:..::   .||..:...:.|.|  .|.:|:..
  Rat   259 ATNASVFKYYIHDLSDIIDQCCDLGYHASLNRALRTFL---SAELNLEQSKHEGL--DAIENAVE 318

  Fly   276 KI--RDQAQQLTREYNLQCCYLFYPVLKQHIQYDFEACDNDPVRKVTAEHESAAETLTKEAKNLA 338
            .:  ....|:|...||    .:|.|.:|    ::|:....|...::.|:....:| |.:..:.|.
  Rat   319 NLDATSDKQRLMEMYN----NVFCPPMK----FEFQPHMGDMASQLCAQQPVQSE-LVQRRQQLQ 374

  Fly   339 GRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPNGPDLDT-KIEEFRDQIRRSETEKTKAEAC 402
            .|                                     |.| |||       ..|.:|| .||.
  Rat   375 SR-------------------------------------LSTLKIE-------NEEVKKT-MEAT 394

  Fly   403 LQCLRD----GGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEE--- 460
            ||.::|    ...:|.:..|.:.:|...:.|.|.:.:|..:.|..:.....::.||.:..:|
  Rat   395 LQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLE 459

  Fly   461 -----TQAAAQ----TKPKQEQQ-----LSRDRTFSDSEDEPEVRPSAA---------------- 495
                 |:..|:    .|...|.|     |:|..:....:|..:..|...
  Rat   460 GRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLRHEG 524

  Fly   496 ---AASSAAAASSSMMASSAGGWDDPTEVNWGAGEEED-DKD--------------EPIVPE--- 539
               .:.|....:....|...|  :||.     ||::.| |.|              .|:.|:
  Rat   525 VFRVSGSQVEVNDIKNAFERG--EDPL-----AGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIF 582

  Fly   540 --------------------------PKEAIFKCTALYSY----------TAQNPDELTIVENEQ 568
                                      ||..:.....|:::          ...:|..|.|.....
  Rat   583 HDLIACVTMDNLQERAVHIRKVLLVLPKPTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPS 647

  Fly   569 LEVVGEGDGDGWLRAR-NYRGEEGYVPH-NYLDIDQETAGSAF----------NGTSGNQLRSQI 621
            |..|.||......:|. |...:...:.| |.....:|..|..:          :.|.|..:.::.
  Rat   648 LMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPNPRELEGPIYSRGGSMEDYCDSTHGETISAED 712

  Fly   622 SFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIK 686
            |         .:|.|.:...|.|:...|.|            ||.:||......||:|::|..:.
  Rat   713 S---------TQDVTAEHHTSDDECEPIEA------------IAKFDYVGRTARELSFKKGASLL 756

  Fly   687 IITKTAHGVDDGWWEGELDGKFGNFPS--LVVEECD----EMGEPLSEGGDESPPPTAAPTFALP 745
            :..:.:    |.||||..:|..|..|.  :||::.:    |...|.||....|.||....|   .
  Rat   757 LYQRAS----DDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVMSEPPEEKVT---A 814

  Fly   746 PAPALPPEYAHELELELTEDMFGSQDTADEDSGYIPNGAAAPSIPPPVLIQEPGMEDDLSDDGQP 810
            ...|..|...|..::.|...   ::.....:||.|.....:.|         .|:...|:|...|
  Rat   815 RTGASCPSGGHVADIYLANI---NKQRKRPESGSIRKAFRSDS---------HGLGSSLTDSSSP 867

  Fly   811 -------PPSLP--PPQLAKAGG-----SAPGSGSKVEKGAAAGGANTLNLGMAQIIVTAATPMV 861
                   |.|.|  ...|.|.|.     |..||.:.:.:.::...    .:...||..||..
  Rat   868 GVGASCRPSSQPIMSQNLPKEGPDKCSISGHGSLNSISRHSSLKN----RMDSPQIRKTATA--- 925

  Fly   862 EDGADKSF----PPVGESDAQPVEPVSK---------EQPAEVAKKPDI---APKPLAKVAPQSA 910
              |..|||    |...|..||.:|....         |:.:.....||:   ..:|| |.:|..|
  Rat   926 --GRSKSFNNHRPMDPEVIAQDIEATMNSALNELQELERQSSAKHTPDVVLDTLEPL-KTSPVVA 987

  Fly   911 PAKEGNAGVRPVVSITLTEYPSCDAEDQQSFSEGTDSASVADVPVLQDAEDPFNEKAKGESGD 973
            |..|                ||.....|                :|:|.|..| :::...:||
  Rat   988 PTSE----------------PSSPLHTQ----------------LLKDPEPAF-QRSASTAGD 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	67/326 (21%)
		SH3_FCHSD_1	545..600	CDD:212695	12/66 (18%)
		SH3	663..718	CDD:354299	18/56 (32%)
		PRK12323	<725..956	CDD:237057	54/260 (21%)
Srgap2	XP_006249844.1	F-BAR_srGAP2	26..289	CDD:153366	61/284 (21%)
		RhoGAP_srGAP	487..674	CDD:239848	28/193 (15%)
		SH3_srGAP1-3	732..784	CDD:212888	17/67 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810