DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nwk and Fchsd1

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	XP_006526066.1	Gene:	Fchsd1 / 319262	MGIID:	2441771	Length:	690	Species:	Mus musculus

Alignment Length:	846	Identity:	219/846 - (25%)
Similarity:	362/846 - (42%)	Gaps:	190/846 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQPPPRKGNYVKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYL 65
            |||||||....:.:|....||::.||.:.|.|.|||||||.::.:|:|:|:.|.::|.|::..:|
Mouse     1 MQPPPRKVKPAQEVKLRFLEQLSILQTRQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFL 65

  Fly    66 NKKIPNIPDIKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYKLAIA 130
            .::.....:....|.    .::..||.:|:......:.||.|.:.::.......   |..|..:.
Mouse    66 KREGQRSGEADSRGR----TVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTG---RSAKEQVL 123

  Fly   131 KRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQK 195
            ::....:...|.|:..||.::.:::|.|...:......::||.|::.:|.:.....|.|.|||||
Mouse   124 RKGTESLQQAQAEVLQSVRELSRSRKLYGQRQRVWALAQEKAADVQARLNRSDHGIFHSRTSLQK 188

  Fly   196 NSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMG 260
            .|.:::::.....::...|||:|:|:|.|.|||...|:..:|...:..:.:.:.|.:.:.|.|:|
Mouse   189 LSTKLSAQSAQYSQQLRAARNEYLLNLVATNAHLAHYYQEELPALLKVLVSELSEYLRDPLTLLG 253

  Fly   261 RTELLTCSATQNSFGKIRDQAQ---QLTREYN--------LQCCYLFYPVLKQHIQYDFEACDND 314
            .|||       .:...|.:.|:   :.|.:.|        ||...:|.|...|    .|:....|
Mouse   254 HTEL-------EAAEMILEHARHGGKATSQVNWEQDVKLFLQGPGVFSPTPPQ----QFQPAGAD 307

  Fly   315 PVRKVT--AEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPNGPD 377
            .|..:.  |...:....|.||.:....|..:: ..|:.:..:  :.|.|....|:....:  .|.
Mouse   308 QVCGLEWGAGGMAGESGLEKEVQRWTSRAARD-YKIQHHGHR--VLQRLEQRRQQAPGRE--APG 367

  Fly   378 LDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWVQEAENMGVQELTRSASSISMRTDAS 442
            ::.:::|.|:.|||::..:.|..|.|..|::.|::|..|::.|
Mouse   368 VEQRLQEVRENIRRAQVSQVKGAARLALLQEAGLDVQRWLKPA---------------------- 410

  Fly   443 GQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSSM 507
                               ...||.:.:||::||..|.     .:.::.|:|..|
Mouse   411 -------------------MTQAQDEVEQERRLSEARL-----SQRDLSPTAEDA---------- 441

  Fly   508 MASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKCTA--LYSYTAQNPDELTIVENEQLE 570
               ....:|:..|    |||.   .:||..|........|.|  ::.|.|...|||||.|.|.||
Mouse   442 ---ELSDFDECEE----AGEL---FEEPAPPALATRPLPCPAHVVFGYQAGREDELTITEGEWLE 496

  Fly   571 VVGEGDGDGWLRARNYRGEEGYVPHNYLDIDQETAGSAFNGTSGNQLRSQISFSSVDYTVDNEDQ 635
            |:.|||.|.|::|||..||.|:||..||:....:...:.:|                  :||
Mouse   497 VIEEGDADEWVKARNQHGEAGFVPERYLNFPDLSLPESCHG------------------IDN--- 540

  Fly   636 TVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIKIITKTAHGVDDGWW 700
                 .|..:.:..:|.            |||.|...:|:||:|.||..|:::.:...|||||:|
Mouse   541 -----PSGGEPTAFLAR------------ALYSYTGQSEEELSFPEGALIRLLPRAQDGVDDGFW 588

  Fly   701 EGELDGKFGNFPSLVVEECDEMGEP----LSEGGDESPPPTAAPTFALPPAP--ALPPEYAHELE 759
            .||..|..|.||||:|||.  :|.|    ||:.....|.| :.|:|: ||||  ||
Mouse   589 RGEFGGHVGVFPSLLVEEL--LGPPGPPELSDPEQMLPSP-SPPSFS-PPAPTCAL--------- 640

  Fly   760 LELTEDMFGSQDTADEDSGYIPNGAAAPSIPPPVLIQEPGMEDDLSD---DGQPPPSLPPPQLAK 821
                                  :|:.||::|...::..||..|.:..   ..:|||  |||  ||
Mouse   641 ----------------------DGSTAPALPSDKVLDCPGPLDMMVPRLRPMRPPP--PPP--AK 679

  Fly   822 A 822
            |
Mouse   680 A 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	67/264 (25%)
		SH3_FCHSD_1	545..600	CDD:212695	29/56 (52%)
		SH3	663..718	CDD:354299	26/54 (48%)
		PRK12323	<725..956	CDD:237057	29/107 (27%)
Fchsd1	XP_006526066.1	BAR	16..275	CDD:386243	68/272 (25%)
		SH3_FCHSD_1	470..526	CDD:212695	29/55 (53%)
		SH3	550..607	CDD:388381	28/68 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849667
Domainoid	1	1.000	59	1.000	Domainoid score	I10638
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2327
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52870
OrthoDB	1	1.010	-	-		D154524at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105517
Panther	1	1.100	-	-	LDO	PTHR15735
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2901
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.770