Protein Alignment nwk and Srgap1

DIOPT Version :10

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_001178713.1
• Gene: Srgap1 / 314903
• RGDID: 1566260
• Length: 1085
• Species: Rattus norvegicus
• Alignment Length: 1136
• Identity: 220/1136 - (19%)
• Similarity: 377/1136 - (33%)
• Gaps: 317/1136 - (27%)

  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDI 75
            ||.::....||...|:.:.:....||:|::.|..|::.:|..||.:|.|::.:::.|........
  Rat    21 VKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQ 85

  Fly    76 KMEGMEERWNMWSVWRTVLEE--NEKLARARLAAIEV------FQQQIADEAKVLRDYKLAIAKR 132
            :.:..:...:..:.|..:|.:  .|....|.|:.|.:      |.|...|..::.:..| .||.:
  Rat    86 QFKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSK-EIAFQ 149

  Fly   133 SLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNS 197
            ....::.|..||:    .|.||...|..|...|.....:|...|||...:.|.....|...:::.
  Rat   150 LHEDLMKVLNELY----TVMKTYHMYHSESISAESKLKEAEKQEEKQMGRSGDPVFHIRLEERHQ 210

  Fly   198 ARVTSRK-ELLEE-----------KSSGARNDYVLSLAAANAHQNRYFTVDLQTTM--------- 241
            .|.:.:| |.::|           ||..|||:|:|:|.|.||...:|:..||...:
  Rat   211 RRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHA 275

  Fly   242 ---TTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKI--RDQAQQLTREYNLQCCYLFYPVLK 301
               ..:..|:   .|||.:...|.|.|  ...:|:...:  |...|:....|....|    |.:|
  Rat   276 SLNRALRTYL---SAEYNLETSRHEGL--DIIENAVDNLEPRSDKQRFMEMYPAAFC----PPMK 331

  Fly   302 QHIQYDFEACDNDPVRKVTAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQ 366
                ::|::...|.|.:|:|:....||.:.:            |..::.....|
  Rat   332 ----FEFQSHMGDEVCQVSAQQPVQAELMLR------------NQQLQSRLATL----------- 369

  Fly   367 RTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRD----GGINVDEWVQEAENMGVQE 427
                          |||        ||..|...||.||.::|    ...:|.|..|.:.:....:
  Rat   370 --------------KIE--------SEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVK 412

  Fly   428 LTRSASSISMRTDASGQGENPSSDSFYDSDKEE--------TQAAAQ------------------ 466
            .|.|.:.:|..:.|..:.....::.||.....|        |:..|:
  Rat   413 STVSETYLSKPSIAKRRANQQETEQFYFMKLREFLEGSSLITKLQAKHDLLQRTLGEGHRAEYMT 477

  Fly   467 TKP------KQEQQLSRDRTFSDS-----------EDEPEVRPSAAAAS---------------- 498
            |:|      .|:.:.||.|:..::           :|..:|.|....:.
  Rat   478 TRPPNVPPKPQKHRKSRPRSQYNAKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFR 542

  Fly   499 -SAAAASSSMMASSAGGWDDPT-------EVNWGAGEEE---DDKDEPIVPE------------- 539
             |.:....:.:.:|....::|.       ::|..||..:   ...:.|:.|:
  Rat   543 VSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRID 607

  Fly   540 ----------------PKEAIFKCTALYS-------YTAQN---PDELTIVENEQLEVVGEGDGD 578
                            |:..:.....|::       |:.:|   |..|.|.....|..|.|....
  Rat   608 NLYERALHIHKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQ 672

  Fly   579 GWLRAR-NYRGEEGYVPHNYLDID-QETAGSAFNG--TSGNQLRSQIS----FSSVDYTVDNEDQ 635
            ...:|. |...:...:.|..:..| :|..|..:..  ..|:...|..|    ...||.....|..
  Rat   673 VSCQAHVNEIVKTIIIHHETIFPDAKELDGPVYEKCMAGGDYCDSPYSEHGTLEEVDQDAGTEPH 737

  Fly   636 TVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIKIITKTAHGVDDGWW 700
            |     |.|:...|.|            ||.:||...:..||:|::|..:.:.    |...:.||
  Rat   738 T-----SEDECEPIEA------------IAKFDYVGRSARELSFKKGASLLLY----HRASEDWW 781

  Fly   701 EGELDGKFGNFPS--LVVEECDE-MGEPLSEGGDESPPPTAAPTFALPPAPALPPEYAHELELEL 762
            ||..:|..|..|.  :||::.|: ..:.||:..|........|
  Rat   782 EGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVP---------------------- 824

  Fly   763 TEDMFGSQD----TADEDSGYIPNGAAAPSIPPPVLIQEPGMEDDLSDDGQPPPSLPPPQLAKAG 823
             ||...|:|    |......|:........ |||     ||.....:.||..|  |.||......
  Rat   825 -EDKSSSKDMNSPTDRHSDSYLARQRKRGE-PPP-----PGRRPGRTSDGHCP--LHPPHALSNS 880

  Fly   824 GSAPGS-----------------GSKVEKGAAAGGANTLNLGMAQIIVTAATPMVEDGADKSFPP 871
            ....||                 ....|:....|..:..|:.....:....:|.:. .:..|...
  Rat   881 SIDLGSPNLTGHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIR-RSTSSGQY 944

  Fly   872 VGESDAQPVEPVSKEQPAE------------------VAKKPDIAPKPLAKVAPQSAPAKEGNAG 918
            .|.:|.:|::|.:..|..|                  |...||:....|.:|.....|| .....
  Rat   945 TGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTVKHAPDVVLDTLEQVKNSPTPA-TSTES 1008

  Fly   919 VRPVVSITLTEYPSCDAEDQQSFSEGTDSAS 949
            :.|:.|:||.   |.:.:.::|.|..:|:.|
  Rat  1009 LSPLHSVTLR---SSEPQLRRSTSSSSDTMS 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:472257	68/298 (23%)
		SH3_FCHSD_1	545..600	CDD:212695	12/65 (18%)
		YgiM	<562..668	CDD:442337	23/113 (20%)
		SH3	663..718	CDD:473055	18/56 (32%)
		PRK12323	<725..956	CDD:481241	50/264 (19%)
Srgap1	NP_001178713.1	F-BAR_srGAP1	26..278	CDD:153367	59/256 (23%)
		RhoGAP_srGAP	502..689	CDD:239848	23/186 (12%)
		SH3_srGAP1-3	747..799	CDD:212888	17/67 (25%)