DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nwk and Fnbp1l

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	XP_038958371.1	Gene:	Fnbp1l / 310839	RGDID:	1305386	Length:	622	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	137/707 - (19%)
Similarity:	233/707 - (32%)	Gaps:	239/707 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKMEGMEERW 84
            :|...|....|...|.||...:|..:|..:|::|::.|..:..:|..|:       ..:..|.|:
  Rat    22 DQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKR-------SSKDEEPRF 79

  Fly    85 NMWSVWRTVLEE-NEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQKELHLSV 148
            .....:..:|.| |:...:..:.|.|:..:...:..:...|.|             .::::||..
  Rat    80 TSCIAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLK-------------TERKMHLQE 131

  Fly   149 G------------DVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVT 201
            |            .:|.:||.:  |..|..  .:||:...|:|.....:   :...::|...::.
  Rat   132 GRKAQQYLDMCWKQMDNSKKKF--ERECRE--AEKAQQSYERLDNDTNA---TKADVEKAKQQLN 189

  Fly   202 SRKELLEEKSSGARNDYVLSLAAANAHQNRYFTV------------DLQTTMTTMENY------- 247
            .|..:.:|.    :|:|...|...|..|:::|.|            |.:.|:...|.|
  Rat   190 LRTHMADEN----KNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSE 250

  Fly   248 -----VFERVAEYLMLMGR-------TELL------------------------------TCSAT 270
                 :..:..|.::|..:       ::::                              |.||:
  Rat   251 RKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTVSDGTISAS 315

  Fly   271 QNSFGKI--------------------RDQAQQLTREYNLQCCYLFY---PVLKQHIQYDFEA-- 310
            :...||:                    :.|:..||.      ..||.   |...|.:....|.
  Rat   316 KQEGGKMDSKSTAGKAKGKLWLFGKKPKPQSPPLTP------TSLFTSSPPNGSQFLTLSIEPVH 374

  Fly   311 -CDND--------P-----VRKVTAEHESAAETLT-----KEAKNLAGRVVKENASIRENAKKLA 356
             |.|:        |     .|..:.:...|.|..:     :..|.|..|:.:.|..:::.:.:..
  Rat   375 YCMNEIKTGKPRIPSFRSLKRGWSMKMGPALEDFSHLPPEQRRKKLQQRIDELNRGLQKESDQKE 439

  Fly   357 LCQSLRD----SGQRTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWV 417
            ....::|    :.|..||.     .|..|:.|..:.|.|...|..|.||              |:
  Rat   440 ALNKMKDVYEKNPQMGDPG-----SLQPKLAETMNNIDRLRMEIHKNEA--------------WL 485

  Fly   418 QEAE-NMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTF 481
            .|.| ..||:...|.:|.|:....   ||......|:.|...:|.:.    .|:|....|.
  Rat   486 SEVEGKTGVRGDRRHSSDINHLVT---QGRESPEGSYTDDANQEVRG----PPQQHGHHSE---- 539

  Fly   482 SDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFK 546
                                             :||         |.|||       :|..||..
  Rat   540 ---------------------------------FDD---------EFEDD-------DPLPAIGH 555

  Fly   547 CTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDIDQE 603
            |.|:|.:...|...|.:.|.|.|.::.|..||||.|||...|||||||..|:|:..|
  Rat   556 CKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTTYIDVTLE 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	55/354 (16%)
		SH3_FCHSD_1	545..600	CDD:212695	24/54 (44%)
		SH3	663..718	CDD:354299
		PRK12323	<725..956	CDD:237057
Fnbp1l	XP_038958371.1	F-BAR_FNBP1L	22..269	CDD:153359	50/277 (18%)
		HR1_CIP4_FNBP1L	412..492	CDD:212018	20/98 (20%)
		SH3_FNBP1L	554..610	CDD:213005	25/55 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920