Protein Alignment nwk and Fchsd2

DIOPT Version :10

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: XP_008757943.2
• Gene: Fchsd2 / 308864
• RGDID: 1304812
• Length: 764
• Species: Rattus norvegicus
• Alignment Length: 862
• Identity: 271/862 - (31%)
• Similarity: 407/862 - (47%)
• Gaps: 187/862 - (21%)

  Fly     1 MQPPPRKGNYVKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYL 65
            |||||||....:.|:|:..||:.|||.|:|.|||||||:|.|:.|::|:|:.|::.:.|::||||
  Rat     1 MQPPPRKVKVTQELRNIQGEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGIQKLASQYL 65

  Fly    66 NKKIPNIPDIKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYKLAIA 130
            .:   :.|.||.:...:..:|:.||::.||...::|::|:...|.::..|::.|:.:|..|....
  Rat    66 KR---DWPGIKTDDRNDYRSMYPVWKSFLEATMQVAQSRINICENYKNFISEPARAVRSLKEQQL 127

  Fly   131 KRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQK 195
            ||.:..:..:|.||..:|.|:.|.||.||:.|..||.||:|| |||   .|.|.|.|||..||||
  Rat   128 KRCVDQLTKIQTELQETVKDLVKGKKKYFETEQMAHAVREKA-DIE---AKSKLSLFQSRISLQK 188

  Fly   196 NSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMG 260
            .|.::.:|:.....|::.|||||:|:||||||||:||:..||...|..::..|::.:.:||:...
  Rat   189 ASVKLKARRTECNTKATHARNDYLLTLAAANAHQDRYYQTDLLNIMKALDGNVYDHLKDYLIAFS 253

  Fly   261 RTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYPVLKQHIQYDFEACDND----------- 314
            ||||..|.|.||:|..:.:.:.::.|:||||.......|..:...:.|:.||:|
  Rat   254 RTELEACQAMQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAAQLVDI 318

  Fly   315 ---PV----------RKVTAEHESAAE-TLTKEAKNLAGRVVKENASIRENAKKL--ALCQSLRD 363
               ||          |::.:|..:..| :|.|||:..|.||.:|:.:|....:.|  ..|..:..
  Rat   319 ELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNELECHGVAV 383

  Fly   364 SGQRTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWVQEAENMGVQEL 428
            |.|       :..:|:.||:|.|:.||::|..|.||||.|..|:..|::||.|::.|.|..::||
  Rat   384 SEQ-------SRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEEL 441

  Fly   429 -----------TRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFS 482
                       |.:.:..|:..||    |....:.|.|:..                     .|.
  Rat   442 ENERWARPPAVTSNGTLHSLNADA----EREEGEEFEDNMD---------------------VFD 481

  Fly   483 DSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKC 547
            ||...|               |.::                        ::.|:.         |
  Rat   482 DSSSSP---------------SGTL------------------------RNYPLT---------C 498

  Fly   548 TALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDIDQETAGSAFNGT 612
            ..:|||.|..||||||.|:|.|||:.:||.:.|::|||..|:.||||..||..           .
  Rat   499 KVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQF-----------P 552

  Fly   613 SGNQLRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCI--ALYDYDATAED 675
            :.|.|.|.:...:   .:|:...|..:....:.||      ..:..|...|.  |||||:...:|
  Rat   553 TSNSLLSMLQSLA---ALDSRSHTSSNSTEAELVS------GSLNGDASVCFVKALYDYEGQTDD 608

  Fly   676 ELTFEEGDKIKIITKTAHGVDDGWWEGELDGKFGNFPSLVVEECDEMGEPLSEGGDE-------- 732
            ||:|.||..|:|:.|.... |||:||||..|:.|.|||::|||..     .||.||.
  Rat   609 ELSFPEGAIIRIVNKENQD-DDGFWEGEFSGRIGVFPSVLVEELS-----ASENGDTPWTRDIQV 667

  Fly   733 SPPPTAAPTFALPPAPAL--PPEYAHELELELTEDMF--------------------GSQDTADE 775
            ||.|  .|..:|||.|..  ||...:....:.:...|                    .|:.|.|.
  Rat   668 SPSP--KPHTSLPPLPLYDQPPSSPYPSPDKRSSQFFPRSPSANENCLHAESPGFSQASRQTPDT 730

  Fly   776 DSGYIPNGAAAPSIPPP 792
            ..|.:....|||  |||
  Rat   731 SYGKLRPVRAAP--PPP 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:472257	107/264 (41%)
		SH3_FCHSD_1	545..600	CDD:212695	29/54 (54%)
		YgiM	<562..668	CDD:442337	31/107 (29%)
		SH3	663..718	CDD:473055	28/56 (50%)
		PRK12323	<725..956	CDD:481241	25/98 (26%)
Fchsd2	XP_008757943.2	F-BAR_FCHSD2	16..275	CDD:153361	107/265 (40%)
		SCP-1	<258..>447	CDD:114219	56/195 (29%)
		SH3_FCHSD_1	495..551	CDD:212695	30/64 (47%)
		SH3_FCHSD2_2	595..650	CDD:212827	27/55 (49%)