Protein Alignment nwk and Srgap3

DIOPT Version :9

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: XP_006506207.1
• Gene: Srgap3 / 259302
• MGIID: 2152938
• Length: 1104
• Species: Mus musculus
• Alignment Length: 1214
• Identity: 233/1214 - (19%)
• Similarity: 409/1214 - (33%)
• Gaps: 394/1214 - (32%)

  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDI 75
            :|.::....||...|:.:::....||:|:::|..:::.:|..||.||.|::.:: :.||.:..:.
Mouse    21 IKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERF-SSKIRSSREH 84

  Fly    76 KMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQ-------QQIADEAKVLRDYKLA--IAK 131
            :.:..:...:..:.|..||.:..:.:|......::|.       .||:::  |:|.:|.:  |..
Mouse    85 QFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISED--VIRLFKKSKEIGL 147

  Fly   132 RSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKN 196
            :....::.|..||:    .|.||...|..|...|.....:|...|||...|.|....::...:..
Mouse   148 QMHEELLKVTNELY----TVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGELSMNLLRHEDR 208

  Fly   197 SARVTSRK--ELLEEKSSG-----------ARNDYVLSLAAANAHQNRYFTVDLQ---------- 238
            ..|.:|.|  |.::||...           |||||:|:|||.||..::|:..|:.
Mouse   209 PQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGF 273

  Fly   239 --TTMTTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYPVLK 301
              :...|...|:   .|||.:...|.|.|  ...:|:...:..::.:.|  ....|..:|.|.||
Mouse   274 HASLARTFRTYL---SAEYNLETSRHEGL--DVIENAVDNLDSRSDKHT--VMDMCSQVFCPPLK 331

  Fly   302 QHIQYDFEACDNDPVRKVTA------------------------EHESAAETLTKEAKNLAGRVV 342
                ::|:....|.|.:|:|                        |:|...:||....:.|...:.
Mouse   332 ----FEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLT 392

  Fly   343 KENASIRENAKKLALCQSLRDSGQRTDPND------------------------PNGPDLDTKIE 383
            .|:..:.:..:.....:|::.:...|..:.                        .||.:|.||::
Mouse   393 VEDFDVSDAFQHSRSTESIKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQ 457

  Fly   384 EFRDQIRRSETEKTKAEACLQCLRDGGINVDE--WV------------------------QEA-- 420
            ...|.::::..|..:||......|||.:.:..  |:                        |::
Mouse   458 AKHDLLKQTLGEGERAECGTTSRRDGRLRLPHFPWLSCPPAPHFVPHPAFQGRRNARTRNQDSGQ 522

  Fly   421 ------------------ENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSD---------- 457
                              :..|:..:..|...::...::..:||:|..|...:.|
Mouse   523 AIPLVVESCIRFINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKL 587

  Fly   458 -----------KEETQ----------AAAQTKPKQEQQLSRDRT--------------FSDSEDE 487
                       ||..|          .|.:..|.|:..::..|.              .|...||
Mouse   588 YFRGLENPLFPKERFQDLISTIKLENPADRVHPIQQILITLPRVVIVVMRYLFAFLNHLSQYSDE 652

  Fly   488 PEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDK-----DEPIVPEPKE----A 543
            ..:.|    .:.|.....::|....|  .||  |:..|...|..|     .|.|.|.|:|    .
Mouse   653 NMMDP----YNLAICFGPTLMHIPDG--QDP--VSCQAHVNEVIKTIIIHHEAIFPSPRELEGPV 709

  Fly   544 IFKCTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDIDQETAGSA 608
            ..||.|                                     .|||      |.|......|
Mouse   710 YEKCMA-------------------------------------GGEE------YCDSPHSEPG-- 729

  Fly   609 FNGTSGNQLRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATA 673
                         :...||:....|..|.|     ::|..|.|            ||.:||...:
Mouse   730 -------------TIDEVDHDNGTEPHTSD-----EEVEQIEA------------IAKFDYVGRS 764

  Fly   674 EDELTFEEGDKIKIITKTAHGVDDGWWEGELDGKFGNFPS--LVVEECDE-MGEPLSEGGDESPP 735
            ..||:|::|..:.:.    |...:.||||..:|..|..|.  :||::.|: ..:.||:..|..
Mouse   765 PRELSFKKGASLLLY----HRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSE-- 823

  Fly   736 PTAAPTFALPPAPALPPEYAHELELELTEDMFGSQDTADEDSGYI-------PNGAAAPSIPPPV 793
                    ....|.|..:.:.:.:|:..     ::..:|...|.:       .:|||.|.
Mouse   824 --------ASSGPLLDDKASSKNDLQSP-----TEHISDYGFGGVMGRVRLRSDGAAIPR----- 870

  Fly   794 LIQEPGMEDDLSDDGQPP----PSLPPPQLAKAGGSAPG----SGSKVE-----KGAAAGGANTL 845
              :..|     .|...||    ||:..|..|.|..|:|.    |..::|     :.|..|.|.::
Mouse   871 --RRSG-----GDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLSRGRIESPEKRRMATFGSAGSI 928

  Fly   846 NL--------GMAQIIVTAATPMVEDGADKSFPPVGESDAQPVEPVSK---------EQPAEVAK 893
            |.        |::......:|.....|..||..  .|:.|:.:|....         |:...|.:
Mouse   929 NYPDKKALTEGLSMRSTCGSTRHSSLGDHKSLE--AEALAEDIEKTMSTALHELRELERQNTVKQ 991

  Fly   894 KPDIA----------PKPLAKVAPQSAPAKEGNAGVRPVVSITLTEYPSCDAEDQQSFSEGTD-- 946
            .||:.          |.|::     |.||.       |:.:|.:.: |  ||..::|.|..|:
Mouse   992 APDVVLDTLEPLKNPPGPIS-----SEPAS-------PLHTIVIRD-P--DAAMRRSSSSSTEMM 1041

  Fly   947 -------SASVADV----PVLQDAEDPFNEKAKGESGDGSGFEA 979
                   ||.:|..    |.::........::...|..|.|..|
Mouse  1042 TTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	69/298 (23%)
		SH3_FCHSD_1	545..600	CDD:212695	7/54 (13%)
		SH3	663..718	CDD:354299	18/56 (32%)
		PRK12323	<725..956	CDD:237057	58/290 (20%)
Srgap3	XP_006506207.1	F-BAR_srGAP3	26..278	CDD:153368	60/258 (23%)
		RhoGAP_srGAP	510..694	CDD:239848	28/191 (15%)
		SH3_srGAP1-3	753..805	CDD:212888	17/67 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810