DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nwk and Arhgap4

DIOPT Version :10

Sequence 1:NP_001286994.1 Gene:nwk / 39052 FlyBaseID:FBgn0263456 Length:1075 Species:Drosophila melanogaster
Sequence 2:XP_038955379.1 Gene:Arhgap4 / 246249 RGDID:628901 Length:971 Species:Rattus norvegicus


Alignment Length:952 Identity:179/952 - (18%)
Similarity:323/952 - (33%) Gaps:320/952 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLN--------- 66
            ||.::...:||:..|:|:.:...|||.::.:|..:|:.||..||..|.|::.::.:         
  Rat    21 VKVMRGQLSEQLHCLELQGELRRDLLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSS 85

  Fly    67 ------KKIPNIPDIKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDY 125
                  :|.|.:           .:....|..:||...:.:|......||....:|.....:.:.
  Rat    86 REQQSFRKEPTL-----------LSPLHCWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAED 139

  Fly   126 KLAIAKRSLAGIVNVQKELHLSVGDVD----------KTKKSYFDEEHCAH----DVRDKARDIE 176
            ...|.|:|...:..:|.||...|.::.          :|||:|    |..|    :...|.|:.|
  Rat   140 VGRIVKKSKDLVQQLQDELLEVVSELQTQGYLAWASLQTKKTY----HVYHLESMNAETKLREAE 200

  Fly   177 EKLKKKKG----------SFFQSIT---------SLQKNSARVTSRK-ELLEE--KSSGARNDYV 219
            .:.:|:.|          |...:||         ||:|....|..|: :.||.  |.:.|||:|:
  Rat   201 RQEEKRSGKSALPTTTAASATTTITIETELHRKGSLKKGGRLVEKRQAKFLEHKLKCTKARNEYL 265

  Fly   220 LSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKIRDQAQQL 284
            ||||:.||..:.|:..|:...|...:......:.:.|......|..|.::.....|.:.:..:.|
  Rat   266 LSLASVNAAVSNYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSHMQGLGSLEEALEAL 330

  Fly   285 TREYNLQCCYLFYP------VLKQH-------IQYDFEACDNDPVRKVTAEHESAAETLTKEAKN 336
            .            |      ||:.|       :::|::..:.|.|.::..|.|...|.|.: |:|
  Rat   331 D------------PPGDKAKVLEVHAMAFCPPLRFDYQPHEGDEVAEIQVEMELRDEILPR-AQN 382

  Fly   337 LAGR-------------------------VVKENASIRENAKKLALCQSL---------RDSGQR 367
            :..|                         |..|:..|.::.:.....:||         |.:|:|
  Rat   383 IQSRLDQKTIETEEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRR 447

  Fly   368 TDPNDPNGPDLDTKIEEF-----------------RDQIRRSETEKTKAEACLQCL--------- 406
            .:..........||::|:                 ::.|:|...|:.:..:..||.         
  Rat   448 RNQQQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFHKSHH 512

  Fly   407 ---------RDGGINVDEWVQEA--------------------ENMGVQELTRSASSISMRTDAS 442
                     |..|.::::::|..                    ::.|:..::.:.:.|....||.
  Rat   513 PYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGAQARILEIRDAF 577

  Fly   443 GQGENPSSD--SFYDSDK----------------------EETQAAAQTKPKQEQ------QLSR 477
            .:||:|..:  :.:|.|.                      .|..|:|:.:...|:      .|||
  Rat   578 ERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVELVSHLLSR 642

  Fly   478 -----------------------DRTFSDSED-----EPEVRPSAA------------------- 495
                                   |....||.:     .|.:.|..|                   
  Rat   643 LPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLI 707

  Fly   496 ----------------------AASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVP 538
                                  |..||:......:.|.||  :...|:..|...:|||   |:.|
  Rat   708 LQPAWVFPPTAMLPGPIYEKCMAPPSASCLGDGQLESLAG--EPELELKTGTKAQEDD---PLFP 767

  Fly   539 EPKEAIFKCTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGE----EGYVPHNYLD 599
            ...|.:.:..|.::||.:...|||..:.:.|.:......|.|      |||    .|.:||.|:.
  Rat   768 IDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARASSDWW------RGEHAGVRGLIPHKYIT 826

  Fly   600 I----DQETAGSAFNGTSGNQLRSQISFSSVDYTVDNEDQTVDSMQSPD----QVSVIMAPQKRV 656
            :    :::..||... ..|..|....|..::::|...|..|......|.    ...|..:|::.|
  Rat   827 LSEGDEKQMTGSGLQ-AMGESLSHPESVLTLEFTNRLELGTPPEALGPSGHRRHCLVPTSPEQHV 890

  Fly   657 KSDVEWCIALYDYDATAED-ELTFEE--GDKIKIITKTAHGV 695
            :.|          .|.|:: :..|:|  |   |...:..||:
  Rat   891 EMD----------KAVAQNMDSVFKELLG---KAAVRQGHGL 919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nwkNP_001286994.1 BAR 16..281 CDD:472257 70/315 (22%)
SH3_FCHSD_1 545..600 CDD:212695 16/58 (28%)
YgiM <562..668 CDD:442337 24/117 (21%)
SH3 663..718 CDD:473055 8/36 (22%)
PRK12323 <725..956 CDD:481241
Arhgap4XP_038955379.1 F-BAR_srGAP 27..299 CDD:153340 66/286 (23%)
RhoGAP 522..709 CDD:470621 25/186 (13%)
SH3 773..827 CDD:473055 16/59 (27%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.