Protein Alignment nwk and SRGAP2

DIOPT Version :9

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: XP_011507656.1
• Gene: SRGAP2 / 23380
• HGNCID: 19751
• Length: 1084
• Species: Homo sapiens
• Alignment Length: 1177
• Identity: 238/1177 - (20%)
• Similarity: 391/1177 - (33%)
• Gaps: 381/1177 - (32%)

  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDI 75
            ||.::...|||:..|..:.:....||:|::.|..|::.:|..||.:|.|::.::|.|    ....
Human    21 VKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAK----TRST 81

  Fly    76 KMEGMEERWNMWS---VWRTVLEENEKLARARLAAIEVF-------------------------Q 112
            |.:..::..|:.|   .|..:|.:.::.:|......:::                         .
Human    82 KDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVG 146

  Fly   113 QQIADE-AKVLRDYKLAIAKRSLAGIVNVQKELHL----SVGDVDKTKKSYFDEE-HCAHDVRDK 171
            ||:.|: .|||.:            :.:|.|..|:    |:....|.|::...|| .....|:.:
Human   147 QQLQDDLMKVLNE------------LYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQE 199

  Fly   172 ARD------------IEEKLKKKKGSFFQSITSL-QKNSARVTSRKELLEEKSSGARNDYVLSLA 223
            .|.            ||||..::  |..:.|..: :|..|:.|..|    .|:..|||:|:|:|.
Human   200 DRQTPRSPDSTANVRIEEKHVRR--SSVKKIEKMKEKRQAKYTENK----LKAIKARNEYLLALE 258

  Fly   224 AANAHQNRYFTVDLQTTM-------------TTMENYVFERVAEYLMLMGRTELLTCSATQNSFG 275
            |.||...:|:..||...:             ..:..::   .||..:...:.|.|  .|.:|:..
Human   259 ATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFL---SAELNLEQSKHEGL--DAIENAVE 318

  Fly   276 KI--RDQAQQLTREYNLQCCYLFYPVLKQHIQYDFEACDNDPVRKVTAEHESAAETLTKEAKNLA 338
            .:  ....|:|...||    .:|.|.:|    ::|:....|...::.|:....:|.:.:
Human   319 NLDATSDKQRLMEMYN----NVFCPPMK----FEFQPHMGDMASQLCAQQPVQSELVQR------ 369

  Fly   339 GRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPNGPDLDT-KIEEFRDQIRRSETEKTKAEAC 402
                               ||.|:..             |.| |||       ..|.:|| .||.
Human   370 -------------------CQQLQSR-------------LSTLKIE-------NEEVKKT-MEAT 394

  Fly   403 LQCLRD----GGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEE--- 460
            ||.::|    ...:|.:..|.:.:|...:.|.|.:.:|..:.|..:.....::.||.:..:|
Human   395 LQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLE 459

  Fly   461 -----TQAAAQ----TKPKQEQQ-----LSRDRTFSDSEDEPEVRPSAA---------------- 495
                 |:..|:    .|...|.|     |:|..:....:|..:..|...
Human   460 GRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEG 524

  Fly   496 ---AASSAAAASSSMMASSAGGWDDPTEVNWGAGEEED-DKD--------------EPIVPE--- 539
               .:.|....:....|...|  :||.     ||::.| |.|              .|:.|:
Human   525 IFRVSGSQVEVNDIKNAFERG--EDPL-----AGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIF 582

  Fly   540 --------------------------PKEAIFKCTALYSY----------TAQNPDELTIVENEQ 568
                                      ||..:.....|:::          ...:|..|.|.....
Human   583 HDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPS 647

  Fly   569 LEVVGEGDGDGWLRAR-NYRGEEGYVPH-NYLDIDQETAGSAFNGTSGNQLRSQISFSSVDY--- 628
            |..|.||......:|. |...:...:.| |.....:|..|..:  :.|..:.        ||
Human   648 LMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVY--SRGGSME--------DYCDS 702

  Fly   629 ----TVDNEDQTVD----SMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKI 685
                |...||.|.|    ...|.|:...|.|            ||.:||......||:|::|..:
Human   703 PHGETTSVEDSTQDVTAEHHTSDDECEPIEA------------IAKFDYVGRTARELSFKKGASL 755

  Fly   686 KIITKTAHGVDDGWWEGELDGKFGNFPS--LVVEECD----EMGEPLSEGGDESPPP----TAAP 740
            .:..:.:    |.||||..:|..|..|.  :||::.:    |...|.||....|.||    ||..
Human   756 LLYQRAS----DDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARA 816

  Fly   741 TFALPPAPALPPEYA----HELELELTEDMFGSQDTADEDSGYIPNGAAAPSIPPPVLIQEPGME 801
            ..:.|....:...|.    :.|.|:.|:.:...|....| ||         ||.........|:.
Human   817 GASCPSGGHVADIYLANINNNLHLDNTKPVTTKQRKRPE-SG---------SIRKTFRSDSHGLS 871

  Fly   802 DDLSDDGQP--------------PPSLPPPQLAKAGGSAPGSGSKVEKGAAAGGANTLNLGMAQI 852
            ..|:|...|              ..|||.....|...|..||.:.:.:.::...    .|...||
Human   872 SSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKN----RLDSPQI 932

  Fly   853 IVTAATPMVEDGADKSF----PPVGESDAQPVEPVSK---------EQPAEVAKKPDI---APKP 901
            ..||..     |..|||    |...|..||.:|....         |:.:.|...||:   ..:|
Human   933 RKTATA-----GRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEP 992

  Fly   902 LAKVAPQSAPAKEGNAGVRPVVSITLTEYPSCDAEDQQSFSEGTDSASVADVPVLQDAEDPFNEK 966
            | |.:|..||..|                ||.....|                :|:|.|..| ::
Human   993 L-KTSPVVAPTSE----------------PSSPLHTQ----------------LLKDPEPAF-QR 1023

  Fly   967 AKGESGD 973
            :...:||
Human  1024 SASTAGD 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	67/326 (21%)
		SH3_FCHSD_1	545..600	CDD:212695	12/66 (18%)
		SH3	663..718	CDD:354299	18/56 (32%)
		PRK12323	<725..956	CDD:237057	58/268 (22%)
SRGAP2	XP_011507656.1	F-BAR_srGAP2	26..289	CDD:153366	61/284 (21%)
		RhoGAP_srGAP	487..674	CDD:239848	28/193 (15%)
		SH3_srGAP1-3	732..784	CDD:212888	17/67 (25%)
		FTZ	<953..1077	CDD:281812	24/112 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810