Protein Alignment nwk and FNBP1

DIOPT Version :10

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: XP_011516701.1
• Gene: FNBP1 / 23048
• HGNCID: 17069
• Length: 650
• Species: Homo sapiens
• Alignment Length: 728
• Identity: 146/728 - (20%)
• Similarity: 244/728 - (33%)
• Gaps: 230/728 - (31%)

  Fly    20 EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKMEGMEERW 84
            :|...|:...|...|:||...:|..:|:.:|.||::.|..:|.:|..||      ...|..|.::
Human     9 DQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKK------NSKEEEEYKY 67

  Fly    85 NMWSVWRTVLEE-NEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQKELHLSV 148
            .....:.:.|.| |:...:..:.:..:..|.|.|.|:.:::.|.. .|.:.......|:.:....
Human    68 TSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQE-RKSNFHDGRKAQQHIETCW 131

  Fly   149 GDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTSRKELLEEKSSG 213
            ..::.:|:.:  |..|..  .|:|:...||:...     .::|......||  .:.::..:.:..
Human   132 KQLESSKRRF--ERDCKE--ADRAQQYFEKMDAD-----INVTKADVEKAR--QQAQIRHQMAED 185

  Fly   214 ARNDYVLSLAAANAHQNRYF------------------------------TVDLQT--------- 239
            ::.||...|...|..|:.|:                              .||.|.
Human   186 SKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLD 250

  Fly   240 --------------TMTTMENYV--FE-----RVAEYLMLMGRT--------------------- 262
                          :...:|.|.  ||     ...:|...|.||
Human   251 GIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGG 315

  Fly   263 ----------------ELLTC--------------SATQNSFGKIRDQAQQLTREYN-------- 289
                            .|||.              ||..|.....:.|.:.|:..:|
Human   316 KSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPK 380

  Fly   290 LQC---------CYLFY-PVLKQHI---QYDFEACDNDPVRKVTAEHESAAETLTKE-AKNLAGR 340
            :.|         .:.|: .::|:.|   .|.|||.|.....|:.|..|..:....:: .|.|..:
Human   381 IHCFRSLKRGTQSFCFHKELMKRTIGKPTYAFEARDYVLSLKLGATPEDFSNLPPEQRRKKLQQK 445

  Fly   341 VVKENASIRENAKKLALCQSLRD----SGQRTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEA 401
            |.:.|..|::...:......::|    :.|..||     ..||.|:.|....|.:...|..|.||
Human   446 VDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDP-----ASLDHKLAEVSQNIEKLRVETQKFEA 505

  Fly   402 CLQCLRDGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQ 466
                          |:.|.|.               |..|..:.....| ..|||....|    .
Human   506 --------------WLAEVEG---------------RLPARSEQARRQS-GLYDSQNPPT----V 536

  Fly   467 TKPKQEQQLSRDRTFSDSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDD 531
            ....|:::.|.|.::::.:.:                 .|.|...|..:||          |.||
Human   537 NNCAQDRESSPDGSYTEEQSQ-----------------ESEMKVLATDFDD----------EFDD 574

  Fly   532 KDEPIVPEPKEAIFKCTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHN 596
            :      ||..||..|.|||::..||...:::||.|.|.|:.|..||||.|.|....||||||.:
Human   575 E------EPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTS 633

  Fly   597 YLDI--DQETAGS 607
            |:::  |:...|:
Human   634 YVEVCLDKNAKGA 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:472257	61/372 (16%)
		SH3_FCHSD_1	545..600	CDD:212695	25/54 (46%)
		YgiM	<562..668	CDD:442337	21/48 (44%)
		SH3	663..718	CDD:473055
		PRK12323	<725..956	CDD:481241
FNBP1	XP_011516701.1	F-BAR_FBP17	5..257	CDD:153360	47/265 (18%)
		HR1_FBP17	435..511	CDD:212019	20/94 (21%)
		SH3_FBP17	582..637	CDD:213004	25/54 (46%)