DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nwk and Fchsd2

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_950177.2	Gene:	Fchsd2 / 207278	MGIID:	2448475	Length:	764	Species:	Mus musculus

Alignment Length:	862	Identity:	275/862 - (31%)
Similarity:	409/862 - (47%)	Gaps:	187/862 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQPPPRKGNYVKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYL 65
            |||||||....:.|:|:..||:.|||.|:|.|||||||:|.|:.|::|:|:.|::.:.|::||||
Mouse     1 MQPPPRKVKVTQELRNIQGEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGIQKLASQYL 65

  Fly    66 NKKIPNIPDIKMEGMEERWNMWSVWRTVLEENEKLARARLAAIEVFQQQIADEAKVLRDYKLAIA 130
            .:   :.|.||.:...:..:|:.||::.||...::|::|:...|.::..|::.|:.:|..|....
Mouse    66 KR---DWPGIKTDDRNDYRSMYPVWKSFLEGTMQVAQSRINICENYKNFISEPARAVRSLKEQQL 127

  Fly   131 KRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQK 195
            ||.:..:..:|.||..:|.|:.|.||.||:.|..||.||:|| |||   .|.|.|.|||..||||
Mouse   128 KRCVDQLTKIQTELQETVKDLVKGKKKYFETEQMAHAVREKA-DIE---AKSKLSLFQSRISLQK 188

  Fly   196 NSARVTSRKELLEEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMG 260
            .|.::.:|:.....|::.|||||:|:||||||||:||:..||...|..::..|::.:.:||:...
Mouse   189 ASVKLKARRSECNTKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFS 253

  Fly   261 RTELLTCSATQNSFGKIRDQAQQLTREYNLQCCYLFYPVLKQHIQYDFEACDND----------- 314
            ||||.||.|.||:|..:.:.:.::.|:||||.......|..:...:.|:.||:|
Mouse   254 RTELETCQAIQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAAQLVDI 318

  Fly   315 ---PV----------RKVTAEHESAAE-TLTKEAKNLAGRVVKENASIRENAKKL--ALCQSLRD 363
               ||          |::.:|..:..| :|.|||:..|.||.:|:.:|....:.|  ..|..:..
Mouse   319 ELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNELECHGVAL 383

  Fly   364 SGQRTDPNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWVQEAENMGVQEL 428
            |.|       :..:|:.||:|.|:.||::|..|.||||.|..|:..|::||.|::.|.|..::||
Mouse   384 SEQ-------SRAELEQKIDEARESIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEEL 441

  Fly   429 -----------TRSASSISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFS 482
                       |.:.:..|:..||    |....:.|.|:..                     .|.
Mouse   442 ENERWARPPAVTSNGTLHSLNADA----EREEGEEFEDNMD---------------------VFD 481

  Fly   483 DSEDEPEVRPSAAAASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKC 547
            ||...|               |.::                        ::.|:.         |
Mouse   482 DSSSSP---------------SGTL------------------------RNYPLT---------C 498

  Fly   548 TALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDIDQETAGSAFNGT 612
            ..:|||.|..||||||.|:|.|||:.:||.:.|::|||..|:.||||..||..           .
Mouse   499 KVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQF-----------P 552

  Fly   613 SGNQLRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCI--ALYDYDATAED 675
            :.|.|.|.:...:   .:|:...|..:....:.||      ..:..|...|.  |||||:...:|
Mouse   553 TSNSLLSMLQSLA---ALDSRSHTSSNSTEAELVS------GSLNGDASVCFVKALYDYEGQTDD 608

  Fly   676 ELTFEEGDKIKIITKTAHGVDDGWWEGELDGKFGNFPSLVVEECDEMGEPLSEGGDE-------- 732
            ||:|.||..|:|:.|.... |||:||||..|:.|.|||::|||..     .||.||.
Mouse   609 ELSFPEGAIIRILNKENQD-DDGFWEGEFSGRIGVFPSVLVEELS-----ASENGDTPWTREIQI 667

  Fly   733 SPPPTAAPTFALPPAPAL--PPE------------------YAHELELELTEDMF--GSQDTADE 775
            ||.|  .|..:|||.|..  ||.                  .|:|..|......|  .|:.|.|.
Mouse   668 SPSP--KPHTSLPPLPLYDQPPSSPYPSPDKRSSQFFPRSPSANENSLHAESPGFSQASRQTPDT 730

  Fly   776 DSGYIPNGAAAPSIPPP 792
            ..|.:....|||  |||
Mouse   731 SYGKLRPVRAAP--PPP 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	108/264 (41%)
		SH3_FCHSD_1	545..600	CDD:212695	29/54 (54%)
		SH3	663..718	CDD:354299	28/56 (50%)
		PRK12323	<725..956	CDD:237057	28/98 (29%)
Fchsd2	NP_950177.2	F-BAR_FCHSD2	16..275	CDD:153361	108/265 (41%)
		SH3_FCHSD_1	495..551	CDD:212695	30/64 (47%)
		SH3_FCHSD2_2	595..650	CDD:212827	27/55 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849668
Domainoid	1	1.000	195	1.000	Domainoid score	I3157
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8887
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2327
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52870
OrthoDB	1	1.010	-	-		D154524at33208
OrthoFinder	1	1.000	-	-		FOG0007087
OrthoInspector	1	1.000	-	-		oto92177
orthoMCL	1	0.900	-	-		OOG6_105517
Panther	1	1.100	-	-	O	PTHR15735
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5627
SonicParanoid	1	1.000	-	-		X2901
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800