DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nwk and Fnbp1

DIOPT Version :9

Sequence 1:NP_001286994.1 Gene:nwk / 39052 FlyBaseID:FBgn0263456 Length:1075 Species:Drosophila melanogaster
Sequence 2:NP_620269.1 Gene:Fnbp1 / 192348 RGDID:621350 Length:620 Species:Rattus norvegicus


Alignment Length:674 Identity:138/674 - (20%)
Similarity:249/674 - (36%) Gaps:152/674 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKMEGMEERW 84
            :|...|:...|...|:||...:|..:|:.:|.||::.|..:|.:|..||      ...|..|.::
  Rat     9 DQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKK------NSKEEEEYKY 67

  Fly    85 NMWSVWRTVLEE-------NEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQK 142
            .....:.:.|.|       :|.::....:.|.|...:...|.|..|.......:::...|....|
  Rat    68 TACKAFLSTLNELNDYAGQHEVISENMTSQITVDLVRYVQELKQERKSNFHDGRKAQQHIETCWK 132

  Fly   143 ELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTSRKELL 207
            :|       :.:|:.:  |..|..  .|:|:...||:...     .::|......||  .:.::.
  Rat   133 QL-------ESSKRRF--ERDCKE--ADRAQQYFEKMDAD-----INVTKADVEKAR--QQAQMR 179

  Fly   208 EEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMGRTELLTCSATQN 272
            ::.:..::.||.|.|...|..|..|:...:..        :|:::.|    |....::....:..
  Rat   180 QQMAEDSKADYSLILQRFNQEQWEYYHTHIPN--------IFQKIQE----MEERRIVRIGESMK 232

  Fly   273 SFGKIRDQ---------------AQQLTREYNLQCCYLFYPVLKQHIQ--YDFEACD-NDPVRKV 319
            ::.::..|               |:.:.::.:.|   |.....|...:  .|.|..| ..|:::.
  Rat   233 TYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQ---LVVEAYKSGFEPPGDIEFEDYTQPMKRT 294

  Fly   320 TAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTDPND--------PNGP 376
            .:::..::....|......|   |....:....||..|...|....|...|..        ||||
  Rat   295 VSDNSLSSSKEGKPELKFGG---KSRGKLWPFIKKNKLMTLLTSPHQPPPPPPASASPSAVPNGP 356

  Fly   377 D--------LDTKIEEFRDQIRRSETEKTKAEACLQCLRDG-----GINVDEW------------ 416
            .        |..:..||.       |.|.|.. |.:.|:.|     |:..:::            
  Rat   357 QSPKQQKEPLSHRFNEFM-------TSKPKIH-CFRSLKRGLSLKLGVTPEDFSNFPPEQRRKKL 413

  Fly   417 VQEAE--NMGVQELTRSASSISMRTDA---SGQGENPSS------DSFYDSDKEETQA------A 464
            .|:.:  |..:|:.|....:|:...|.   :.|..:|:|      :...:.:|...:|      .
  Rat   414 QQKVDDLNKEIQKETDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVTQNIEKLRLEAHKFEAWL 478

  Fly   465 AQTK---PKQEQQLSRDRTFSDSEDEPEV------RPSAAAASSAAAASSSMMASSAGGWDDPTE 520
            |:.:   |.:.:|..|.....|.:....|      |.|...:.:...:..|.....|..:||   
  Rat   479 AEVEGRLPARSEQARRQSGLYDGQTHQTVTNCAQDRESPDGSYTEEQSQESEHKVLATDFDD--- 540

  Fly   521 VNWGAGEEEDDKDEPIVPEPKEAIFKCTALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARN 585
                   |.||:      ||..||..|.|||::..||...:::||.|.|.|:.|..||||.|.|.
  Rat   541 -------EFDDE------EPLPAIGTCKALYTFEGQNEGTISVVEGETLSVIEEDKGDGWTRIRR 592

  Fly   586 YRGEEGYVPHNYLDI--DQETAGS 607
            ...||||||.:|:::  |:...|:
  Rat   593 NEDEEGYVPTSYVEVYLDKNAKGA 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nwkNP_001286994.1 BAR 16..281 CDD:353336 50/282 (18%)
SH3_FCHSD_1 545..600 CDD:212695 25/54 (46%)
SH3 663..718 CDD:354299
PRK12323 <725..956 CDD:237057
Fnbp1NP_620269.1 Interaction with microtubules 1..334 64/366 (17%)
Required for self-association and induction of membrane tubulation. /evidence=ECO:0000250 1..79 19/75 (25%)
F-BAR_FBP17 5..257 CDD:153360 50/283 (18%)
Required for self-association and induction of membrane tubulation. /evidence=ECO:0000250 251..616 87/394 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 280..314 5/33 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..365 7/32 (22%)
Interaction with RND2 399..551 28/167 (17%)
HR1_FBP17 406..482 CDD:212019 12/75 (16%)
Interaction with PDE6G 494..616 42/137 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..531 6/36 (17%)
Required for interaction with TNKS. /evidence=ECO:0000250 513..616 39/118 (33%)
Interaction with DNM1 and DNM3. /evidence=ECO:0000250 534..616 36/97 (37%)
Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000250 549..616 28/66 (42%)
Interaction with FASLG. /evidence=ECO:0000250 552..609 25/56 (45%)
Interaction with DNM2 and WASL. /evidence=ECO:0000250 552..608 25/55 (45%)
SH3_FBP17 552..608 CDD:213004 25/55 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D348563at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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