DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nwk and mlc-7

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001022669.1	Gene:	mlc-7 / 176811	WormBaseID:	WBGene00023451	Length:	153	Species:	Caenorhabditis elegans

Alignment Length:	131	Identity:	28/131 - (21%)
Similarity:	46/131 - (35%)	Gaps:	46/131 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   760 LELTEDMFGSQDTADE---DSGYIPNGAAAPSI-PPPVLIQEPGMEDDLSDDGQPPPSLPPPQLA 820
            ::...|:|...||..:   ||..:|....|..: |...|:.|                     ::
Worm     7 MDEVHDVFHFHDTLGDGKIDSKQLPTALRAMMLNPTEALLAE---------------------VS 50

  Fly   821 KAGGSAPGSGSKVEK--------GAAAGGANTL-----------NLGMAQIIVTAATPMVEDGAD 866
            ||..|  |:...||:        .||.|.:.||           ..|..||::.....|:::|.:
Worm    51 KARTS--GARITVEEFIPIYKKVEAACGRSTTLKEFQTLLSHFDREGNGQIMLMELKSMLQNGGE 113

  Fly   867 K 867
            |
Worm   114 K 114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336
		SH3_FCHSD_1	545..600	CDD:212695
		SH3	663..718	CDD:354299
		PRK12323	<725..956	CDD:237057	28/131 (21%)
mlc-7	NP_001022669.1	FRQ1	8..139	CDD:227455	28/130 (22%)
		EFh	9..65	CDD:298682	17/78 (22%)
		EF-hand_8	55..109	CDD:290545	13/55 (24%)
		EFh	83..140	CDD:298682	6/32 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900