DRSC/TRiP Functional Genomics Resources

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Protein Alignment nwk and Srgap2

DIOPT Version :9

Sequence 1:NP_001286994.1 Gene:nwk / 39052 FlyBaseID:FBgn0263456 Length:1075 Species:Drosophila melanogaster
Sequence 2:NP_001074480.2 Gene:Srgap2 / 14270 MGIID:109605 Length:1071 Species:Mus musculus


Alignment Length:1184 Identity:233/1184 - (19%)
Similarity:392/1184 - (33%) Gaps:389/1184 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDI 75
            ||.::...|||:..|..:.:....||:|::.|..|::.:|..||.:|.|::.::|.|    ....
Mouse    21 VKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAK----TRST 81

  Fly    76 KMEGMEERWNMWS---VWRTVLEENEKLARARLAAIEVF-------------------------Q 112
            |.:..::..|:.|   .|..:|.:.::.:|......:::                         .
Mouse    82 KDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVG 146

  Fly   113 QQIADE-AKVLRDYKLAIAKRSLAGIVNVQKELHL----SVGDVDKTKKSYFDEE-HCAHDVRDK 171
            ||:.|: .|||.:            :.:|.|..|:    |:....|.|::...|| .....|:.:
Mouse   147 QQLQDDLMKVLNE------------LYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQE 199

  Fly   172 ARD------------IEEKLKKKKGSFFQSITSL-QKNSARVTSRKELLEEKSSGARNDYVLSLA 223
            .|.            ||||..::  |..:.|..: :|..|:.|..|    .|:..|||:|:|:|.
Mouse   200 DRQTPRSPDSTANVRIEEKHVRR--SSVKKIEKMKEKRQAKYTENK----LKAIKARNEYLLALE 258

  Fly   224 AANAHQNRYFTVDLQTTM-------------TTMENYVFERVAEYLMLMGRTELLTCSATQNSFG 275
            |.||...:|:..||...:             ..:..::   .||..:...:.|.|  .|.:|:..
Mouse   259 ATNASVFKYYIHDLSDIIDQCCDLGYHASLNRALRTFL---SAELNLEQSKHEGL--DAIENAVE 318

  Fly   276 KI--RDQAQQLTREYNLQCCYLFYPVLKQHIQYDFEACDNDPVRKVTAEHESAAETLTKEAKNLA 338
            .:  ....|:|...||    .:|.|.:|    ::|:....|...::.|:....:|.:.:      
Mouse   319 NLDATSDKQRLMEMYN----NVFCPPMK----FEFQPHMGDMASQLCAQQPVQSELVQR------ 369

  Fly   339 GRVVKENASIRENAKKLALCQSLRDSGQRTDPNDPNGPDLDT-KIEEFRDQIRRSETEKTKAEAC 402
                               ||.|:..             |.| |||       ..|.:|| .||.
Mouse   370 -------------------CQQLQSR-------------LSTLKIE-------NEEVKKT-MEAT 394

  Fly   403 LQCLRD----GGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEE--- 460
            ||.::|    ...:|.:..|.:.:|...:.|.|.:.:|..:.|..:.....::.||.:..:|   
Mouse   395 LQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLE 459

  Fly   461 -----TQAAAQ----TKPKQEQQ-----LSRDRTFSDSEDEPEVRPSAA---------------- 495
                 |:..|:    .|...|.|     |:|..:....:|..:..|...                
Mouse   460 GRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEG 524

  Fly   496 ---AASSAAAASSSMMASSAGGWDDPTEVNWGAGEEED-DKD--------------EPIVPE--- 539
               .:.|....:....|...|  :||.     ||::.| |.|              .|:.|:   
Mouse   525 IFRVSGSQVEVNDIKNAFERG--EDPL-----AGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIF 582

  Fly   540 --------------------------PKEAIFKCTALYSY----------TAQNPDELTIVENEQ 568
                                      ||..:.....|:::          ...:|..|.|.....
Mouse   583 HDLIACVTMDNLQERAVHIRKVLLVLPKPTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPS 647

  Fly   569 LEVVGEGDGDGWLRAR-NYRGEEGYVPH-NYLDIDQETAGSAF----------NGTSGNQLRSQI 621
            |..|.||......:|. |...:...:.| |.....:|..|..:          :.|.|.      
Mouse   648 LMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPNPRELEGPIYSRGGSMEDYCDSTHGE------ 706

  Fly   622 SFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIK 686
            :.|:.|.|   :|.|.:...|.|:...|.|            ||.:||......||:|::|..:.
Mouse   707 TTSAEDST---QDVTAEHHTSDDECEPIEA------------IAKFDYVGRTARELSFKKGASLL 756

  Fly   687 IITKTAHGVDDGWWEGELDGKFGNFPS--LVVEECD----EMGEPLSEGGDESPPP----TAAPT 741
            :..:.:    |.||||..:|..|..|.  :||::.:    |...|.||....|.||    ||...
Mouse   757 LYQRAS----DDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVMSEPPEEKVTARTG 817

  Fly   742 FALPPAPALPPEYAHELELELTEDMFGSQDTADE-----------DSGYIPNGAAAPSIPPPVLI 795
            .:.|....:...|...:..:......||...|..           ||..:..||:......|::.
Mouse   818 ASCPSGGHVADIYLANINKQRKRPESGSIRKAFRSDSHGLGSSLTDSSSLGVGASCRPSSQPIMS 882

  Fly   796 QEPGMEDDLSDDGQPPPSLPPPQLAKAGGSAPGSGSKVEKGAAAGGANTLNLGMAQIIVTAATPM 860
            |                :||.....|...|..||.:.:.:.::...    .:...||..||..  
Mouse   883 Q----------------NLPKEGPDKCSISGHGSLNSISRHSSLKN----RMDSPQIRKTATA-- 925

  Fly   861 VEDGADKSF----PPVGESDAQPVEPVSK---------EQPAEVAKKPDI---APKPLAKVAPQS 909
               |..|||    |...|..||.:|....         |:.:.....||:   ..:|| |.:|..
Mouse   926 ---GRSKSFNNHRPMDPEVIAQDIEATMNSALNELQELERQSSAKHTPDVVLDTLEPL-KTSPVV 986

  Fly   910 APAKE---------------------GNAG-----VRPVVSITL-------------TEYPSCDA 935
            ||..|                     ..||     .|||.|:.:             |.:|..:|
Mouse   987 APTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPTVFPKTNA 1051

  Fly   936 EDQQSFSEGTDSAS 949
            .     |.|.:|::
Mouse  1052 T-----SPGVNSSA 1060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nwkNP_001286994.1 BAR 16..281 CDD:353336 67/326 (21%)
SH3_FCHSD_1 545..600 CDD:212695 12/66 (18%)
SH3 663..718 CDD:354299 18/56 (32%)
PRK12323 <725..956 CDD:237057 60/295 (20%)
Srgap2NP_001074480.2 F-BAR_srGAP2 26..289 CDD:153366 61/284 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 181..211 5/29 (17%)
RhoGAP_srGAP 487..674 CDD:239848 28/193 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 700..726 8/34 (24%)
SH3_srGAP1-3 732..784 CDD:212888 17/67 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 795..819 8/23 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..918 15/99 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 984..1012 4/27 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1029..1071 6/37 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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