Protein Alignment nwk and Fnbp1

DIOPT Version :10

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: XP_006497754.1
• Gene: Fnbp1 / 14269
• MGIID: 109606
• Length: 649
• Species: Mus musculus
• Alignment Length: 705
• Identity: 137/705 - (19%)
• Similarity: 243/705 - (34%)
• Gaps: 185/705 - (26%)

  Fly    20 EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDIKMEGMEERW 84
            :|...|:...|...|:||...:|..:|:.:|.||::.|..:|.:|..||      ...|..|.::
Mouse     9 DQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKK------NSKEEEEYKY 67

  Fly    85 NMWSVWRTVLEE-------NEKLARARLAAIEVFQQQIADEAKVLRDYKLAIAKRSLAGIVNVQK 142
            .....:.:.|.|       :|.::....:.|.|...:...|.|..|.......:::...|....|
Mouse    68 TACKAFLSTLNEMNDYAGQHEVISENMTSQITVDLMRYVQELKQERKSNFHDGRKAQQHIETCWK 132

  Fly   143 ELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTSRKELL 207
            :|       :.:|:.:  |..|..  .|:|:...||:...     .::|......||  .:.::.
Mouse   133 QL-------ESSKRRF--ERDCKE--ADRAQQYFEKMDAD-----INVTKADVEKAR--QQAQIR 179

  Fly   208 EEKSSGARNDYVLSLAAANAHQNRYFTVDLQTTMTTMENYVFERVAEYLMLMGRTELLTCSATQN 272
            ::.:..::.||.|.|...|..|..|:...:..        :|:::.|    |....::....:..
Mouse   180 QQMAEDSKADYSLILQRFNQEQWEYYHTHIPN--------IFQKIQE----MEERRIVRIGESMK 232

  Fly   273 SFGKIRDQ---------------AQQLTREYNLQCCYLFYPVLKQHIQ--YDFEACD-NDPVRKV 319
            ::.::..|               |:.:.::.:.|   |.....|...:  .|.|..| ..|:::.
Mouse   233 TYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQ---LVVEAYKSGFEPPGDIEFEDYTQPMKRT 294

  Fly   320 TAEHESAAETLTKEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTDPND--------PNGP 376
            .:::..::....|......|   |....:....||..|...|....|...|..        ||||
Mouse   295 VSDNSLSSSKEGKPELRFGG---KSRGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGP 356

  Fly   377 D--------LDTKIEEFRDQIRRSETEKTKAEACLQCLRDG------------------------ 409
            .        |..:..||.       |.|.|.. |.:.|:.|
Mouse   357 QSPKQPKEPLSHRFNEFM-------TSKPKIH-CFRSLKRGTQSLCYHKELMKRTLGKPTHALEA 413

  Fly   410 ---------GINVDEW------------VQEAE--NMGVQELTRSASSISMRTDASGQGENPSSD 451
                     |:..:::            .|:.:  |..:|:.|....:|:...|.  ..:||...
Mouse   414 RDYVLSLKLGVTPEDFSNFPPEQRRKKLQQKVDDLNREIQKETDQRDAITKMKDV--YLKNPQMG 476

  Fly   452 SFYDSDKEETQAAAQTK--------------------PKQEQQLSRDRTFSDSEDEPEVRPSAAA 496
            .....|::.|:.....:                    |.:.:|..|.....|.:....|...|..
Mouse   477 DPASLDQKLTEVTQNIEKLRLEAQKFEAWLAEVEGRLPARSEQARRQSGLYDGQTHQTVTNCAQD 541

  Fly   497 ASSAAAASSSMMASS-------AGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKCTALYSYT 554
            ..|:...|.:...|.       |..:||          |.||:      ||..||..|.|||::.
Mouse   542 RESSPDGSYTEEQSQESEHKVLAPDFDD----------EFDDE------EPLPAIGTCKALYTFE 590

  Fly   555 AQNPDELTIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDI--DQETAGS 607
            .||...:::||.|.|.|:.|..||||.|.|....||||||.:|:::  |:...|:
Mouse   591 GQNEGTISVVEGETLSVIEEDKGDGWTRIRRNEDEEGYVPTSYVEVYLDKNAKGA 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:472257	50/282 (18%)
		SH3_FCHSD_1	545..600	CDD:212695	25/54 (46%)
		YgiM	<562..668	CDD:442337	21/48 (44%)
		SH3	663..718	CDD:473055
		PRK12323	<725..956	CDD:481241
Fnbp1	XP_006497754.1	F-BAR_FBP17	5..257	CDD:153360	50/283 (18%)
		HR1	434..510	CDD:469609	10/77 (13%)
		SH3_FBP17	581..637	CDD:213004	25/55 (45%)