Protein Alignment nwk and Srgap1

DIOPT Version :9

• Sequence 1: NP_001286994.1
• Gene: nwk / 39052
• FlyBaseID: FBgn0263456
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_001074506.1
• Gene: Srgap1 / 117600
• MGIID: 2152936
• Length: 1085
• Species: Mus musculus
• Alignment Length: 1144
• Identity: 211/1144 - (18%)
• Similarity: 387/1144 - (33%)
• Gaps: 333/1144 - (29%)

  Fly    11 VKFLKNLHTEQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKKIPNIPDI 75
            ||.::....||...|:.:.:....||:|::.|..|::.:|..||.:|.|::.:::.|........
Mouse    21 VKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQ 85

  Fly    76 KMEGMEERWNMWSVWRTVLEE--NEKLARARLAAIEV------FQQQIADEAKVLRDYKLAIAKR 132
            :.:..:...:..:.|..:|.:  .|....|.|:.|.:      |.|...|..::.:..| .||.:
Mouse    86 QFKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSK-EIAFQ 149

  Fly   133 SLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHDVRDKARDIEEKLKKKKGSFFQSITSLQKNS 197
            ....::.|..||:    .|.||...|..|...|.....:|...|||...:.|.....|...:::.
Mouse   150 LHEDLMKVLNELY----TVMKTYHMYHSESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQ 210

  Fly   198 ARVTSRK-ELLEE-----------KSSGARNDYVLSLAAANAHQNRYFTVDLQTTM--------- 241
            .|.:.:| |.::|           ||..|||:|:|:|.|.||...:|:..||...:
Mouse   211 RRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHA 275

  Fly   242 ---TTMENYVFERVAEYLMLMGRTELLTCSATQNSFGKI--RDQAQQLTREYNLQCCYLFYPVLK 301
               ..:..|:   .|||.:...|.|.|  ...:|:...:  |...|:....|....|    |.:|
Mouse   276 SLNRALRTYL---SAEYNLETSRHEGL--DIIENAVDNLEPRSDKQRFMEMYPAAFC----PPMK 331

  Fly   302 QHIQYDFEACDNDPVRKVTAEHESAAETL----------------------TKEA--KNLAGRVV 342
                ::|::...|.|.:|:|:....||.:                      |.||  :.:...|.
Mouse   332 ----FEFQSHMGDEVCQVSAQQPVQAELMLRNQQLQSRLATLKIESEEVKKTTEATLQTIQDMVT 392

  Fly   343 KENASIRENAKKLALCQSLRDSGQRTDPNDPN------------------------GPDLDTKIE 383
            .|:..:.|..:.....:|::.:...|..:.|:                        |.:|.||::
Mouse   393 IEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREFLEGSNLITKLQ 457

  Fly   384 EFRDQIRRSETEKTKA------------------------------------------------- 399
            ...|.::|:..|..:|
Mouse   458 AKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNAKLFNGDLETFVKDSGQVIPLI 522

  Fly   400 -EACLQCLRDGGINVDEWVQEAENMGVQELTRSASSISMRTDASGQGENPSSDSFYDSDKEETQA 463
             |:|::.:...|:         ::.|:..::.|...::...::..:||||.||.  .|:.:....
Mouse   523 VESCIRFINLYGL---------QHQGIFRVSGSQVEVNDIKNSFERGENPLSDE--QSNHDINSV 576

  Fly   464 AAQTK-----------PKQE--QQLSRDRTFSDSEDEPEVRPSAAAASSAA--------AASSSM 507
            |...|           ||:.  ..:|..|..:..|....:|........:.        |..:.:
Mouse   577 AGVLKLYFRGLENPLFPKERFTDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHL 641

  Fly   508 MASSAGGWDDPTEVNWGAGEEEDDKDEPI---VPEPKEAIFKCTALYSYTAQNPDEL--TIVENE 567
            ...|.....||..:....|        |.   |||.::.: .|.|       :.:|:  ||:.:.
Mouse   642 SQYSDENMMDPYNLAICFG--------PTLMPVPEIQDQV-SCQA-------HVNEIVKTIIIHH 690

  Fly   568 QLEVVGEGDGDGWLRARNYRG----EEGYVPHNYL-DIDQETAGSAFNGTSGNQLRSQISFSSVD 627
            :.......:.||.:..:...|    :..|..|..| ::||:.      ||.             .
Mouse   691 ETIFPDAKELDGPVYEKCMAGGDYCDSPYSEHGTLEEVDQDA------GTE-------------P 736

  Fly   628 YTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIKIITKTA 692
            :|.::|.:.:::                        ||.:||...:..||:|::|..:.:.
Mouse   737 HTSEDECEPIEA------------------------IAKFDYVGRSARELSFKKGASLLLY---- 773

  Fly   693 HGVDDGWWEGELDGKFGNFPS--LVVEECDE-MGEPLSEGGDESPPPTAAPTFALPPAPALPPEY 754
            |...:.||||..:|..|..|.  :||::.|: ..:.||:..|..  .::.|
Mouse   774 HRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSE--ASSGP-------------- 822

  Fly   755 AHELELELTEDMFGSQD----TADEDSGYIPNGAAAPSIPPPVLIQEPGMEDDLSDDGQPPPSLP 815
                   :|||...|:|    |......|:........ |||     ||.....:.||..|  |.
Mouse   823 -------VTEDKSSSKDMNSPTDRHSDSYLARQRKRGE-PPP-----PGRRPGRTSDGHCP--LH 872

  Fly   816 PPQLAKAGGSAPGS-----------------GSKVEKGAAAGGANTLNLGMAQIIVTAATPMVED 863
            ||..........||                 ....|:....|..:..|:.....:....:|.:.
Mouse   873 PPHALSNSSIDLGSPNLASHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIR- 936

  Fly   864 GADKSFPPVGESDAQPVEPVSKEQPAE------------------VAKKPDIAPKPLAKVAPQSA 910
            .:..|....|.:|.:|::|.:..|..|                  |...||:....|.:|.....
Mouse   937 RSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTVKHAPDVVLDTLEQVKNSPT 1001

  Fly   911 PAKEGNAGVRPVVSITLTEYPSCDAEDQQSFSEGTDSAS 949
            || .....:.|:.::.|.   ..:.:.::|.|..:::.|
Mouse  1002 PA-TSTESLSPLHNVALR---GSEPQIRRSTSSSSETMS 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	68/298 (23%)
		SH3_FCHSD_1	545..600	CDD:212695	11/61 (18%)
		SH3	663..718	CDD:354299	18/56 (32%)
		PRK12323	<725..956	CDD:237057	47/264 (18%)
Srgap1	NP_001074506.1	F-BAR_srGAP1	26..278	CDD:153367	59/256 (23%)
		RhoGAP_srGAP	502..689	CDD:239848	34/213 (16%)
		SH3_srGAP1-3	747..799	CDD:212888	16/79 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810