DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nwk and Trip10

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	XP_038938836.1	Gene:	Trip10 / 116717	RGDID:	621145	Length:	603	Species:	Rattus norvegicus

Alignment Length:	689	Identity:	134/689 - (19%)
Similarity:	246/689 - (35%)	Gaps:	205/689 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKK-IPNIPDIKMEGMEER 83
            :|...|:...|...|||:...:|..:|..||:||::.|..:..:||.|: ..:.|:||....:
  Rat     9 DQFEVLERHTQWGLDLLDKYVKFVKERVEVEQSYAKQLRSLVKKYLPKRPAKDDPEIKFSQQQ-- 71

  Fly    84 WNMWSVWRTVLEENEKLARARLAA--------IEV--------------------FQQQIADEAK 120
                |..:.:.|.|:...:..|.|        :|:                    .|||:.:..|
  Rat    72 ----SFVQLLQEVNDFAGQRELVAESLGIRVCLELAKYSQEMKQERKMHFQEGRRAQQQLENGFK 132

  Fly   121 VLRDYKLAI------AKRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHD------------ 167
            .|.:.|...      |:::......:.::::.:..||:|.|:......|.|.:
  Rat   133 QLENSKRKFERDCREAEKAAHTAERLDQDINATKADVEKAKQQAHLRNHMAEESKNEYAAQLQRF 197

  Fly   168 --------------VRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTSRKELLE-----EKSSG 213
                          :.||.:|::|:...:.|:.:..::..:.....:..:  .||     .:|..
  Rat   198 NRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELQVVPIIGK--CLEGMKVAAESVD 260

  Fly   214 ARNDYVLSLAAANAHQNRYFTV-DLQTTMTTMENY--VFERVAEYLML---MGRTELLTCSATQN 272
            |:||   |......|::.:... ||:     .|::  |..||.....|   .||.||...|:...
  Rat   261 AKND---SKVLIELHKSGFARPGDLE-----FEDFSQVMNRVPSDSSLGTPDGRPELRAASSRSR 317

  Fly   273 S----FGKIRDQAQQLTREYNLQCCYLFYPVLKQHIQYDFE------ACDNDPVRKVTAEHESAA 327
            :    |||     :...|..:|.       :|..|:.....      ....||:..::...:|..
  Rat   318 AKRWPFGK-----KNKPRPPSLS-------LLGGHLPSTLSDGPSSPRSGRDPLAILSEISKSVK 370

  Fly   328 ETLT-----------------------KEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTD 369
            ..|.                       ::.|.|..::.:.|..:::...:....:.::|..::|
  Rat   371 PRLASFRSLRGSRGTVVTEDFSHLPPEQQRKRLQQQLEERNRELQKEEDQREALKKMKDVYEKT- 434

  Fly   370 PNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWVQEAENMGVQELTRSASS 434
            |...:...|:.:|.|....|.|.:.|..|.||              |:.|||:   :.|:....|
  Rat   435 PQMGDPASLEPRIAETLGNIERLKLEVQKYEA--------------WLAEAES---RVLSNRGDS 482

  Fly   435 ISMRT---DASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFSDSEDEPEVRPSAAA 496
            :|..|   |........||.|..:|..::.:.:::..|.:|
  Rat   483 LSRHTRPPDPPTTAPPDSSSSSNNSGSQDNKESSEEPPSEE------------------------ 523

  Fly   497 ASSAAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKCTALYSYTAQNPDEL 561
                             |.|.|...     |.::|.:||..|     |.:|.|:|.:...:...:
  Rat   524 -----------------GQDTPIYT-----EFDEDFEEPASP-----IGQCVAIYHFEGSSEGTV 561

  Fly   562 TIVENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDI 600
            ::.|.|.|.::.|..||||.|.|..:|.|||||.:||.:
  Rat   562 SMSEGEDLSLMEEDKGDGWTRVRRKQGGEGYVPTSYLRV 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	66/336 (20%)
		SH3_FCHSD_1	545..600	CDD:212695	21/54 (39%)
		SH3	663..718	CDD:354299
		PRK12323	<725..956	CDD:237057
Trip10	XP_038938836.1	F-BAR_CIP4-like	5..257	CDD:153337	45/255 (18%)
		HR1_CIP4_FNBP1L	395..475	CDD:212018	19/97 (20%)
		SH3_CIP4-like	546..600	CDD:212844	21/53 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920