DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nwk and Trip10

DIOPT Version :9

Sequence 1:	NP_001286994.1	Gene:	nwk / 39052	FlyBaseID:	FBgn0263456	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001229318.1	Gene:	Trip10 / 106628	MGIID:	2146901	Length:	603	Species:	Mus musculus

Alignment Length:	686	Identity:	134/686 - (19%)
Similarity:	249/686 - (36%)	Gaps:	199/686 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EQVAKLQLKNQHECDLLEDIRQFTIKRSAVEKSYSESLLKISSQYLNKK-IPNIPDIKMEGMEER 83
            :|...|:...|...|||:...:|..:|:.||::|::.|..:..:||.|: ..:.|::|....:
Mouse     9 DQFEVLERHTQWGLDLLDKYVKFVKERAEVEQAYAKQLRSLVKKYLPKRPTKDDPEVKFSQQQ-- 71

  Fly    84 WNMWSVWRTVLEENEKLARARLAA--------IEV--------------------FQQQIADEAK 120
                |..:.:.|.|:...:..|.|        :|:                    .|||:.:..|
Mouse    72 ----SFVQLLQEVNDFAGQRELVAESLGIRVCLELAKYSQEMKQERKMHFQEGRRAQQQLENGFK 132

  Fly   121 VLRDYKLAI------AKRSLAGIVNVQKELHLSVGDVDKTKKSYFDEEHCAHD------------ 167
            .|.:.|...      |:::......:.::::.:..||:|.|:......|.|.:
Mouse   133 QLENSKRKFERDCREAEKAAHTAERLDQDINATKADVEKAKQQAHLRNHMAEESKNEYAAQLQRF 197

  Fly   168 --------------VRDKARDIEEKLKKKKGSFFQSITSLQKNSARVTSRKELLE-----EKSSG 213
                          :.||.:|::|:...:.|:.:..::..:.....:..:  .||     .:|..
Mouse   198 NRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELQVVPIIGK--CLEGMKVAAESVD 260

  Fly   214 ARNDYVLSLAAANAHQNRYFTV-DLQTTMTTMENY--VFERVAEYLML---MGRTELLTCSATQN 272
            |:||   |......|::.:... ||:     .|::  |..||.....|   .||.||...|:...
Mouse   261 AKND---SQVLIELHKSGFARPGDLE-----FEDFSQVINRVPSDSSLGTPDGRPELRAASSRSR 317

  Fly   273 S----FGKIRDQAQQLTREYNLQCCYLFYPVLKQHIQYDFE------ACDNDPVRKVTAEHESAA 327
            :    |||     :...|..:|.       :|..|:.....      ....||:..::...:|..
Mouse   318 AKRWPFGK-----KNKPRPPSLS-------LLGGHLPSTLSDGPSSPRSGRDPLAILSEISKSVK 370

  Fly   328 ETLT-----------------------KEAKNLAGRVVKENASIRENAKKLALCQSLRDSGQRTD 369
            ..|.                       ::.|.|..::.:.|..:::...:....:.::|..::|
Mouse   371 PRLASFRSFRGGRGTVATEDFSHLPPEQQRKRLQQQLEERNRELQKEEDQREALKKMKDVYEKT- 434

  Fly   370 PNDPNGPDLDTKIEEFRDQIRRSETEKTKAEACLQCLRDGGINVDEWVQEAENMGVQELTRSASS 434
            |...:...|:.:|.|....|.|.:.|..|.||              |:.|||:   :.|:....|
Mouse   435 PQMGDPASLEPRIAETLGNIERLKLEVQKYEA--------------WLAEAES---RVLSNRGDS 482

  Fly   435 ISMRTDASGQGENPSSDSFYDSDKEETQAAAQTKPKQEQQLSRDRTFSDSEDEPEVRPSAAAASS 499
            :|..    .:..:|.:.:..||....|.:.:|           |...|.||:.|
Mouse   483 LSRH----ARPPDPPTTAPPDSSSSSTNSGSQ-----------DNKESSSEEPP----------- 521

  Fly   500 AAAASSSMMASSAGGWDDPTEVNWGAGEEEDDKDEPIVPEPKEAIFKCTALYSYTAQNPDELTIV 564
                        :.|.|.|...     |.::|.:||..|     |.:|.|:|.:...:...:::.
Mouse   522 ------------SEGQDTPIYT-----EFDEDFEEPASP-----IGQCVAIYHFEGSSEGTVSMS 564

  Fly   565 ENEQLEVVGEGDGDGWLRARNYRGEEGYVPHNYLDI 600
            |.|.|.::.|..||||.|.|..:|.|||||.:||.:
Mouse   565 EGEDLSLMEEDKGDGWTRVRRKQGAEGYVPTSYLRV 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nwk	NP_001286994.1	BAR	16..281	CDD:353336	64/336 (19%)
		SH3_FCHSD_1	545..600	CDD:212695	21/54 (39%)
		SH3	663..718	CDD:354299
		PRK12323	<725..956	CDD:237057
Trip10	NP_001229318.1	Required for podosome formation and interaction with AKAP9 and microtubules. /evidence=ECO:0000250	1..117		23/113 (20%)
		Required for translocation to the plasma membrane in response to insulin	1..117		23/113 (20%)
		F-BAR_CIP4-like	5..257	CDD:153337	43/255 (17%)
		Interaction with PDE6G. /evidence=ECO:0000250	293..603		81/386 (21%)
		Interaction with CDC42. /evidence=ECO:0000250	293..539		56/318 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..358		13/74 (18%)
		HR1_CIP4_FNBP1L	395..475	CDD:212018	19/97 (20%)
		Required for interaction with FASLG and localization to lysosomes. /evidence=ECO:0000250	471..603		45/181 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..541		18/106 (17%)
		Interaction with DNM2 and WASL. /evidence=ECO:0000269\|PubMed:16418535	487..543		17/94 (18%)
		Interaction with DNM1 and WASL. /evidence=ECO:0000250	532..603		27/74 (36%)
		Required for podosome formation. /evidence=ECO:0000250	540..603		24/66 (36%)
		Interaction with WAS. /evidence=ECO:0000250	546..603		21/55 (38%)
		SH3_CIP4-like	546..600	CDD:212844	21/53 (40%)
		Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000250	548..603		20/53 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D348563at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820