DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment teq and CD163

DIOPT Version :9

Sequence 1:	NP_648288.2	Gene:	teq / 39048	FlyBaseID:	FBgn0023479	Length:	2792	Species:	Drosophila melanogaster
Sequence 2:	NP_004235.4	Gene:	CD163 / 9332	HGNCID:	1631	Length:	1156	Species:	Homo sapiens

Alignment Length:	759	Identity:	185/759 - (24%)
Similarity:	265/759 - (34%)	Gaps:	301/759 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  2196 GNGQCLKKEEICDGKK---------------NCPNGKDE-ANCPP-SDYEVRLSGGESPNMGRIE 2243
            |:|:.......|.|.:               ||.:.:|. ..|.. |:.|:||:.|.:...||||
Human   109 GSGRIWMDHVSCRGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIE 173

  Fly  2244 VKANGQWGYVCDDKFGLKDADVVCRELGFQMG-AQEVRGSSFYAPPNQDFNYLMDEVECHGNETK 2307
            :|..|:||.||||.|.:..|.|:||:|  :.| |....|||.:...:....:  |::.|:|||:.
Human   174 IKFQGRWGTVCDDNFNIDHASVICRQL--ECGSAVSFSGSSNFGEGSGPIWF--DDLICNGNESA 234

  Fly  2308 LGQCAFKGWGVHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDECA 2372
            |..|..:|||.|||...|.|||.|                ||
Human   235 LWNCKHQGWGKHNCDHAEDAGVIC----------------SK----------------------- 260

  Fly  2373 AVCQAPVQYRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAKIEKNIFGN 2437
               .|.:..||..|.....|||||:..|.||::|||.::...|.|||..:|.  |..:  ...|.
Human   261 ---GADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGC--PTAV--TAIGR 318

  Fly  2438 SN-----GPIWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCSAGPPPRSQRYSQTQIKG 2497
            .|     |.||||.|.|.|:|.:|.||.|..||:|.|||.||..:.||.|..      .:.:::|
Human   319 VNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSD------LELRLRG 377

  Fly  2498 G-------------RSLGR------------------------ETTPKTYSQI------------ 2513
            |             |.||:                        :|:.:.||:|
Human   378 GGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSC 442

  Fly  2514 -----GLWERSSKAVHTPRRCGIFK-DDLT-DEY--------AHREERVVRGNVAQRGR------ 2557
                 .||:           |..:: ..|| |.|        ||||.|:|.|::...||
Human   443 NGNETSLWD-----------CKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHG 496

  Fly  2558 HPW-----------QATIRTRGRGGISSHWCGAVVISKRHLLTAAHCLYGSPKGAYFVRVGDHYA 2611
            ..|           .|::..|      ...||.||    .:|..||  :|...|..:
Human   497 DTWGSICDSDFSLEAASVLCR------ELQCGTVV----SILGGAH--FGEGNGQIW-------- 541

  Fly  2612 NIAESSEVDSFIENWYLHENF---------RKGT--HMNN---------DIALVVLKTPLKFSDY 2656
              ||..:.:.       ||:.         .:||  |..:         :|.||..|||
Human   542 --AEEFQCEG-------HESHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTP------ 591

  Fly  2657 VQPICLPDKNAELVEDRKCTISGWGS-----------------IKSGV--STPA----------- 2691
                |  :...||.     |:..|||                 :|.||  |||.
Human   592 ----C--EGRVELK-----TLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQI 645

  Fly  2692 -----------QVLGSAELPILADHVCKQSNVYGSAMSEGMFCAGSMDESVDACEGDSGGP---- 2741
                       |.:|...:..|...:|....|      ..:.|:|:..:::.:|...|.||
Human   646 WRHMFHCTGTEQHMGDCPVTALGASLCPSEQV------ASVICSGNQSQTLSSCNSSSLGPTRPT 704

  Fly  2742 -----LVCSDDDGETLYGLISWGQHCGFKNRPGVYVRVNHYIDW 2780
                 .|...:.|:  ..|::.|..|..:      |.:.|...|
Human   705 IPEESAVACIESGQ--LRLVNGGGRCAGR------VEIYHEGSW 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
teq	NP_648288.2	CBM_14	65..115	CDD:279884
		ChtBD2	136..184	CDD:214696
		ChtBD2	215..261	CDD:214696
		ChtBD2	284..327	CDD:214696
		CBM_14	521..569	CDD:279884
		ChtBD2	608..654	CDD:214696
		ChtBD2	709..752	CDD:214696
		CBM_14	782..830	CDD:279884
		ChtBD2	864..909	CDD:214696
		CBM_14	942..993	CDD:279884
		RCR	<1051..1126	CDD:304939
		RCR	<1116..1210	CDD:304939
		ChtBD2	1324..1369	CDD:214696
		ChtBD2	1474..1518	CDD:214696
		LDLa	2193..2222	CDD:238060	7/41 (17%)
		SR	2229..2331	CDD:214555	43/102 (42%)
		SRCR	2234..2332	CDD:278931	41/98 (42%)
		LDLa	2337..2370	CDD:197566	2/32 (6%)
		SR	2382..2480	CDD:214555	43/102 (42%)
		SRCR	2386..2480	CDD:278931	41/98 (42%)
		Tryp_SPc	2546..2781	CDD:214473	62/322 (19%)
		Tryp_SPc	2547..2784	CDD:238113	61/321 (19%)
CD163	NP_004235.4	SR	51..152	CDD:214555	7/42 (17%)
		SRCR	56..152	CDD:278931	7/42 (17%)
		SR	159..259	CDD:214555	44/119 (37%)
		SRCR	164..259	CDD:278931	42/114 (37%)
		SR	266..366	CDD:214555	43/103 (42%)
		SRCR	271..366	CDD:278931	41/98 (42%)
		SR	373..473	CDD:214555	16/110 (15%)
		SRCR	378..473	CDD:278931	15/105 (14%)
		SR	479..578	CDD:214555	24/127 (19%)
		SRCR	483..578	CDD:278931	22/123 (18%)
		SR	583..683	CDD:214555	24/122 (20%)
		SRCR	588..683	CDD:278931	21/117 (18%)
		SR	719..819	CDD:214555	6/28 (21%)
		SRCR	724..819	CDD:278931	5/23 (22%)
		SR	929..1029	CDD:214555
		SRCR	934..1029	CDD:278931
		Internalization signal	1096..1099
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41013
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910