DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment teq and Prss12

DIOPT Version :9

Sequence 1:	NP_648288.2	Gene:	teq / 39048	FlyBaseID:	FBgn0023479	Length:	2792	Species:	Drosophila melanogaster
Sequence 2:	NP_445956.1	Gene:	Prss12 / 85266	RGDID:	69238	Length:	761	Species:	Rattus norvegicus

Alignment Length:	825	Identity:	248/825 - (30%)
Similarity:	342/825 - (41%)	Gaps:	236/825 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2104 RRHPNLPDPFTEHHPNSSPHQHHHHHRHPHEHSADFHIRHPELPNPFPLKNETPQHQDLNDDWDL 2168
            |..|.|..|.  |.|:.||.:..|.|..|...      |.|..|. |||....|..|
  Rat    20 RADPVLHSPL--HRPHPSPPRSQHAHYLPSSR------RPPRTPR-FPLPPRAPAAQ-------- 67

  Fly  2169 LPNSNAEEVTPKLATRSSFNTQCDFDCGNGQ-----------CLKKEEI---------------- 2206
            .|...:...||...:|.         ||.|:           ||..:|:
  Rat    68 RPQLLSTRHTPPTISRR---------CGAGEPWGNATNLGVPCLHWDEVPPFLERSPPASWAELR 123

  Fly  2207 ------C---DGK-------KNCPNGKDEANCP----PSDYEVRLSGGESPNMGRIEVKANGQWG 2251
                  |   ||.       :|.....|...|.    |:...:||.||:|.:.||:|:...||||
  Rat   124 GQPHNFCRSPDGAGRPWCFYRNAQGKVDWGYCDCGQGPALPVIRLVGGKSGHEGRVELYHAGQWG 188

  Fly  2252 YVCDDKFGLKDADVVCRELGFQMGAQEVRGSSF---YAPPNQDFNYLMDEVECHGNETKLGQCAF 2313
            .:|||::...||:|:||:||....|:....:.|   ..|      .|:|||.|.|||..:.||..
  Rat   189 TICDDQWDDADAEVICRQLGLSGIAKAWHQAHFGEGSGP------ILLDEVRCTGNELSIEQCPK 247

  Fly  2314 KGWGVHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDECAAVCQAP 2378
            ..||.||||..|.|||:|                                             ||
  Rat   248 SSWGEHNCGHKEDAGVSC---------------------------------------------AP 267

  Fly  2379 VQ---YRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAKIEKNIFGNSNG 2440
            :.   .||.||::.:||||||.:.|.||:||||.:...:..|||..:||....:...|.|..|:.
  Rat   268 LTDGVIRLSGGKSVHEGRLEVYYRGQWGTVCDDGWTEMNTYVACRLLGFKYGKQSSVNHFEGSSR 332

  Fly  2441 PIWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHC---------SAGPPPR-----SQRYS 2491
            |||||.|.|.|.|.|..||:...||.|:|:|.|||.|.|         |.|.|.|     ::|..
  Rat   333 PIWLDDVSCSGKEASFIQCSRRQWGRHDCSHREDVGLTCYPDSDGHRLSPGFPIRLMDGENKREG 397

  Fly  2492 QTQI----KGG----------------RSLGRE--TTPKTYSQIGLWE-----------RSSKAV 2523
            :.::    :.|                |.||.:  ...:|.:..|..:           .:.||:
  Rat   398 RVEVFVNGQWGTICDDGWTDKHAAVICRQLGYKGPARARTMAYFGEGKGPIHMDNVKCTGNEKAL 462

  Fly  2524 ----------HTPRR-------CGIF---------KDDLTD----EYAHREE-RVVRGNVAQRGR 2557
                      |..|.       |..:         |:.|:.    ...||.: |::.||.:.||.
  Rat   463 ADCVKQDIGRHNCRHSEDAGVICDYYEKKTSGHGNKETLSSGCGLRLLHRRQTRIIGGNNSLRGA 527

  Fly  2558 HPWQATIRTRGRGGISSHWCGAVVISKRHLLTAAHCL--YGSPKGAYFVRVGDHYANIAESSEVD 2620
            .||||::|.:...|.....|||.::|...:||||||.  ||:...:|.|||||::..:.|..|.|
  Rat   528 WPWQASLRLKSTHGDGRLLCGATLLSSCWVLTAAHCFTRYGNNSRSYAVRVGDYHTLVPEGFEQD 592

  Fly  2621 SFIENWYLHENFRKGTHMNNDIALVVLKTP----LKFSDYVQPICL------PDKNAELVEDRKC 2675
            ..::...:|.|:|..: .:.|||||.|:..    .:.|.:|.|.||      |.|.|.     .|
  Rat   593 IGVQQIVIHRNYRPDS-SDYDIALVRLQGSGEQCARLSTHVLPACLPLWRERPQKTAS-----NC 651

  Fly  2676 TISGWGSIKSGVSTPAQVLGSAELPILADHVCKQSNVYGSAMSEGMFCAGSM--DESVDACEGDS 2738
            .|:|||......|   :.|..|.:|:|....||:.  |....:..|.|||::  |..||:|:|||
  Rat   652 HITGWGDTGRAYS---RTLQQAAVPLLPKRFCKER--YKGLFTGRMLCAGNLQEDNRVDSCQGDS 711

  Fly  2739 GGPLVCSDDDGET--LYGLISWGQHCGFKNRPGVYVRVNHYIDWI 2781
            ||||:|...| ||  :||:.|||..||.|:.||||.||..::.||
  Rat   712 GGPLMCEKPD-ETWVVYGVTSWGYGCGIKDTPGVYTRVPAFVPWI 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
teq	NP_648288.2	CBM_14	65..115	CDD:279884
		ChtBD2	136..184	CDD:214696
		ChtBD2	215..261	CDD:214696
		ChtBD2	284..327	CDD:214696
		CBM_14	521..569	CDD:279884
		ChtBD2	608..654	CDD:214696
		ChtBD2	709..752	CDD:214696
		CBM_14	782..830	CDD:279884
		ChtBD2	864..909	CDD:214696
		CBM_14	942..993	CDD:279884
		RCR	<1051..1126	CDD:304939
		RCR	<1116..1210	CDD:304939
		ChtBD2	1324..1369	CDD:214696
		ChtBD2	1474..1518	CDD:214696
		LDLa	2193..2222	CDD:238060	11/71 (15%)
		SR	2229..2331	CDD:214555	45/104 (43%)
		SRCR	2234..2332	CDD:278931	42/100 (42%)
		LDLa	2337..2370	CDD:197566	0/32 (0%)
		SR	2382..2480	CDD:214555	47/106 (44%)
		SRCR	2386..2480	CDD:278931	44/102 (43%)
		Tryp_SPc	2546..2781	CDD:214473	95/250 (38%)
		Tryp_SPc	2547..2784	CDD:238113	96/251 (38%)
Prss12	NP_445956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..89		22/88 (25%)
		KR	83..159	CDD:214527	13/84 (15%)
		SR	166..265	CDD:214555	45/104 (43%)
		SRCR	171..266	CDD:278931	43/145 (30%)
		SR	273..372	CDD:214555	46/98 (47%)
		SRCR	278..371	CDD:278931	43/92 (47%)
		SR	386..485	CDD:214555	12/98 (12%)
		SRCR	391..485	CDD:278931	11/93 (12%)
		Zymogen activation region. /evidence=ECO:0000250	505..516		2/10 (20%)
		Tryp_SPc	516..755	CDD:214473	95/250 (38%)
		Tryp_SPc	517..758	CDD:238113	96/251 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6450
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D158600at2759
OrthoFinder	1	1.000	-	-		FOG0001772
OrthoInspector	1	1.000	-	-		oto96581
orthoMCL	1	0.900	-	-		OOG6_106745
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3236
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820