Protein Alignment teq and LOXL2

DIOPT Version :10

• Sequence 1: NP_648288.2
• Gene: teq / 39048
• FlyBaseID: FBgn0023479
• Length: 2792
• Species: Drosophila melanogaster
• Sequence 2: NP_002309.1
• Gene: LOXL2 / 4017
• HGNCID: 6666
• Length: 774
• Species: Homo sapiens
• Alignment Length: 747
• Identity: 171/747 - (22%)
• Similarity: 254/747 - (34%)
• Gaps: 298/747 - (39%)

  Fly  2228 EVRLSGGESPNM-GRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQD 2291
            ::||:|.:..:. ||:||..:||||.||||.|.:..|.|||||||: :.|:....||.|.  ..:
Human    57 QLRLAGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGY-VEAKSWTASSSYG--KGE 118

  Fly  2292 FNYLMDEVECHGNETKLGQCAFKGWGVHNCGVDEVAGVTC------------------------- 2331
            ....:|.:.|.|||..|..|...||||.:|...|..||.|
Human   119 GPIWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLNIQV 183

  Fly  2332 --------------KVPVMK--------------CPNNYWLCHTSKECIPPAFVCD--------- 2359
                          :.|||:              | :.:|....|:      .||.
Human   184 EDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQIC-DKHWTAKNSR------VVCGMFGFPGERT 241

  Fly  2360 -NTP------------------DCAD-------------------KSDEC-----AAVCQAPVQ- 2380
             ||.                  ||..                   |:..|     |.|...|.|
Human   242 YNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVSCVPGQV 306

  Fly  2381 -------------------YRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFG 2426
                               .||.||....|||:||..:|.||:||||.::|.||.|.|..:| ||
Human   307 FSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELG-FG 370

  Fly  2427 PAK--IEKNIFGNSNGPIWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCSAGPPPRSQR 2489
            .||  :..:..|...|||.|:::.|.|||.||..|. :|.....|||.||..:.|:.   |....
Human   371 SAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCK-FNAESQGCNHEEDAGVRCNT---PAMGL 431

  Fly  2490 YSQTQIKGGRSLGRETTPKTYSQIGLWERSSKAVHTPRRCGIFKDDLTDEYAHREERVVRGNVAQ 2554
            ..:.::.|||                                      :.|..|.|.:|..|
Human   432 QKKLRLNGGR--------------------------------------NPYEGRVEVLVERN--- 455

  Fly  2555 RGRHPW-----------QATIRTRGRG-GISS-------HWCGAVVISKRHL---------LTAA 2591
             |...|           :|.:..|..| |.:|       :|.|.|..:|..:         |:.|
Human   456 -GSLVWGMVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLA 519

  Fly  2592 HCLY-----GSPKGAYFVRVGDHYANIAESSEVDSFIENWYLHENFRKGTHMNNDIALVVLKTPL 2651
            ||.:     ..|:|.  |:.|   |.:|.|......:.|   .|..::.|:: .|..:.:|:..:
Human   520 HCRHDGEDVACPQGG--VQYG---AGVACSETAPDLVLN---AEMVQQTTYL-EDRPMFMLQCAM 575

  Fly  2652 KFSDYVQPICLPDKNAELVEDRKCTISGWGSIKSGVSTPAQVLGSAELPILAD------------ 2704
            :.:      ||   :|...:....|  |:..:   :...:|:..:.:    :|
Human   576 EEN------CL---SASAAQTDPTT--GYRRL---LRFSSQIHNNGQ----SDFRPKNGRHAWIW 622

  Fly  2705 HVCKQS-------------NVYGSAMSEG---MFCAGSMDESVDACEGDSGGPLVCSD--DDGET 2751
            |.|.:.             |:.|:.::||   .||....:     ||||......|::  |.|.|
Human   623 HDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTE-----CEGDIQKNYECANFGDQGIT 682

  Fly  2752 LYGLISWGQHCGFKNRPGVYVRVNHYID--WI 2781
            :                |.:....|.||  |:
Human   683 M----------------GCWDMYRHDIDCQWV 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
teq	NP_648288.2	CBM_14	65..115	CDD:426342
		ChtBD2	136..184	CDD:214696
		ChtBD2	215..261	CDD:214696
		ChtBD2	284..327	CDD:214696
		ChtBD2	521..567	CDD:214696
		ChtBD2	608..654	CDD:214696
		ChtBD2	709..752	CDD:214696
		CBM_14	782..829	CDD:426342
		ChtBD2	864..909	CDD:214696
		CBM_14	942..993	CDD:426342
		Med15	1029..>1325	CDD:312941
		ChtBD2	1324..1369	CDD:214696
		ChtBD2	1474..1518	CDD:214696
		PHA03247	<1587..1906	CDD:223021
		LDLa	2193..2222	CDD:238060
		SR	2229..2331	CDD:214555	43/102 (42%)
		LDLa	2337..2370	CDD:197566	10/93 (11%)
		SR	2382..2480	CDD:214555	44/99 (44%)
		Tryp_SPc	2547..2784	CDD:238113	57/300 (19%)
LOXL2	NP_002309.1	SR	58..159	CDD:214555	43/103 (42%)
		SR	196..301	CDD:214555	16/111 (14%)
		SR	326..425	CDD:214555	44/100 (44%)
		SR	435..544	CDD:214555	29/155 (19%)
		Lysyl-oxidase like	548..751		33/194 (17%)
		Lysyl_oxidase	548..746	CDD:460102	33/194 (17%)