Protein Alignment teq and LOXL1

DIOPT Version :10

• Sequence 1: NP_648288.2
• Gene: teq / 39048
• FlyBaseID: FBgn0023479
• Length: 2792
• Species: Drosophila melanogaster
• Sequence 2: NP_005567.2
• Gene: LOXL1 / 4016
• HGNCID: 6665
• Length: 574
• Species: Homo sapiens
• Alignment Length: 673
• Identity: 134/673 - (19%)
• Similarity: 188/673 - (27%)
• Gaps: 288/673 - (42%)

  Fly  1017 EQTEPESNLSLDGGNQ--------PPGKYQAPYYSNGGYPTPSQNN------------GGYQTP- 1060
            :::|..|.:.|.|..|        .|.:.|||     ..|.|.:..            |..|.|
Human    67 QRSESSSRVLLAGAPQAQQRRSHGSPRRRQAP-----SLPLPGRVGSDTVRGQARHPFGFGQVPD 126

  Fly  1061 --------------------SQNNGGYQAPFQNNGGYQPSYQGNGGYTPTYQNPFEGYHQPNQSS 1105
                                ||...|..|...:...:..:|:    ..|:|...|.....|..|.
Human   127 NWREVAVGDSTGMARARTSVSQQRHGGSASSVSASAFASTYR----QQPSYPQQFPYPQAPFVSQ 187

  Fly  1106 YQTNGGYQPPLPPHGGYQPPSQTY-----------GGF---------------QQPNRTYEDFHN 1144
            |:             .|.|.|:||           ||.               .||...||::
Human   188 YE-------------NYDPASRTYDQGFVYYRPAGGGVGAGAAAVASAGVIYPYQPRARYEEY-- 237

  Fly  1145 PSQTVGGFQ--PPYSVKGGYQPHNQLNGGYNQPNQSSSFQANGGYQPPSQVNRGYQTSFESNG-- 1205
                 ||.:  |.|..:|.|....:   .|..|..          .||..::|.|..|..|.|
Human   238 -----GGGEELPEYPPQGFYPAPER---PYVPPPP----------PPPDGLDRRYSHSLYSEGTP 284

  Fly  1206 GYQ-----PPLETNKGHQVPSQINGGYQPRVDGNRGYQPPNELNGGYQPPNELNGAYPAPSQLNG 1265
            |::     |..|..:.|        |..||:    |:.||..     .||.|   ||..|..|
Human   285 GFEQAYPDPGPEAAQAH--------GGDPRL----GWYPPYA-----NPPPE---AYGPPRAL-- 327

  Fly  1266 GYQPPLEGNLGYRPLSQQNSGYQPPQPSTGGYQPPFQSTGSGHYPGQDAPYAIPTPLLCPEKISG 1330
              :||      |.|:  ::|...||.....|.|....|.||.:.|.|:..   ..|.|.|:
Human   328 --EPP------YLPV--RSSDTPPPGGERNGAQQGRLSVGSVYRPNQNGR---GLPDLVPD---- 375

  Fly  1331 LFPNPFDATGYLTCIDGHTLPRQCQPLDVFSVSQGYCLPEQHVNKTD-----------RVPFERT 1384
              ||...|:.|:.  ..|....:|...:....|..|. ||    .||           ||..:.|
Human   376 --PNYVQASTYVQ--RAHLYSLRCAAEEKCLASTAYA-PE----ATDYDVRVLLRFPQRVKNQGT 431

  Fly  1385 QTYQDNSLDCPRDFLGFVVYPFDCSKYLSCGPSGMKLLNCPGEQHYSISHGFCKPVDQVQREDRL 1449
            ..:..|.             |....::.||            .|||   |.    :|:....|.|
Human   432 ADFLPNR-------------PRHTWEWHSC------------HQHY---HS----MDEFSHYDLL 464

  Fly  1450 YTINELHIIFEWTQKMMIVG-AVTACPEGITGTLPHPRVPTKYLRCGPGQAEMYDCPSQQIFSVS 1513
            ...         |.|.:..| ..:.|.|..|              |..|..:.|.|.|.
Human   465 DAA---------TGKKVAEGHKASFCLEDST--------------CDFGNLKRYACTSH------ 500

  Fly  1514 RRVCVLDDKLSSYDRTDYLVRGVNSGWMDPSNDNRQSKSYETSGRDQFGNRYTTRTTTTTRVIGD 1578
                               .:|::.|            .|:|...|                |..
Human   501 -------------------TQGLSPG------------CYDTYNAD----------------IDC 518

  Fly  1579 RWTDMNMQRPSG--VGVEQNPHH 1599
            :|.|:...:|..  :.|..||.:
Human   519 QWIDITDVQPGNYILKVHVNPKY 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
teq	NP_648288.2	CBM_14	65..115	CDD:426342
		ChtBD2	136..184	CDD:214696
		ChtBD2	215..261	CDD:214696
		ChtBD2	284..327	CDD:214696
		ChtBD2	521..567	CDD:214696
		ChtBD2	608..654	CDD:214696
		ChtBD2	709..752	CDD:214696
		CBM_14	782..829	CDD:426342
		ChtBD2	864..909	CDD:214696
		CBM_14	942..993	CDD:426342
		Med15	1029..>1325	CDD:312941	81/371 (22%)
		ChtBD2	1324..1369	CDD:214696	9/44 (20%)
		ChtBD2	1474..1518	CDD:214696	8/43 (19%)
		PHA03247	<1587..1906	CDD:223021	4/15 (27%)
		LDLa	2193..2222	CDD:238060
		SR	2229..2331	CDD:214555
		LDLa	2337..2370	CDD:197566
		SR	2382..2480	CDD:214555
		Tryp_SPc	2547..2784	CDD:238113
LOXL1	NP_005567.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..123		12/60 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..374		47/182 (26%)
		dnaA	240..>374	CDD:455861	46/181 (25%)
		Interaction with FBLN5. /evidence=ECO:0000250|UniProtKB:P97873	311..369		23/80 (29%)
		Lysyl-oxidase like	370..574		52/293 (18%)
		Lysyl_oxidase	370..569	CDD:460102	52/293 (18%)