Protein Alignment teq and HGFAC

DIOPT Version :10

• Sequence 1: NP_648288.2
• Gene: teq / 39048
• FlyBaseID: FBgn0023479
• Length: 2792
• Species: Drosophila melanogaster
• Sequence 2: NP_001284368.1
• Gene: HGFAC / 3083
• HGNCID: 4894
• Length: 662
• Species: Homo sapiens
• Alignment Length: 716
• Identity: 178/716 - (24%)
• Similarity: 261/716 - (36%)
• Gaps: 175/716 - (24%)

  Fly  2147 PNPFPLKNETPQHQDLNDDWDLLPNSNAEEVTPK-LATRSSFNTQCDFDCGNGQCLKKEEICDGK 2210
            |.|...:.|:|:           ||:.|....|. |.|..:..|..
Human    35 PQPGGNRTESPE-----------PNATATPAIPTILVTSVTSETPA------------------- 69

  Fly  2211 KNCP--NGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKDADVVCRELGFQ 2273
            .:.|  .|......||....|       |:....:.:|..:.|..|...|         |..|..
Human    70 TSAPEAEGPQSGGLPPPPRAV-------PSSSSPQAQALTEDGRPCRFPF---------RYGGRM 118

  Fly  2274 MGAQEVRGSSF----YAPPNQD----FNYLMDEVECHGNETKLGQCA----FKGWGVHNCGVDEV 2326
            :.|....||:.    ....|.|    :.|.::.....|....|..||    ..|....|  ..:.
Human   119 LHACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSN--TQDP 181

  Fly  2327 AGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKS--------DECAAVCQAPV-QYR 2382
            ....|     .||..:    |.|:|        .|..|.|::        |..|.|.|..| |..
Human   182 QSYHC-----SCPRAF----TGKDC--------GTEKCFDETRYEYLEGGDRWARVRQGHVEQCE 229

  Fly  2383 LEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQV---------ACNSMGFFG------PAKIEK 2432
            ..|||...||   .:|.....|.|   .|..:..:         || ..||.|      |.  |:
Human   230 CFGGRTWCEG---TRHTACLSSPC---LNGGTCHLIVATGTTVCAC-PPGFAGRLCNIEPD--ER 285

  Fly  2433 NIFGNSNGPIWLDQVMCFGNETSIDQCNHWN----WGEHNCNHTEDVAL-----HCSAGPPPRSQ 2488
            ...||..|...:......|.     .|..||    :.|.:.:.....||     |.....|...:
Human   286 CFLGNGTGYRGVASTSASGL-----SCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDE 345

  Fly  2489 R--------------YSQTQIKGGRSLGRETTPKTYSQIGLWERSSKAVHTPRR-CGIFKDDLTD 2538
            |              |.:.:.....:.|||:..:......|.....:.....|: ||
Human   346 RPWCYVVKDSALSWEYCRLEACDLETEGRESLTRVQLSPDLLATLPEPASPGRQACG-------- 402

  Fly  2539 EYAHREE-----RVVRGNVAQRGRHPWQATIRTRGRGGISSHWCGAVVISKRHLLTAAHCL-YGS 2597
             ..|::.     |::.|:.:..|.|||.|.|.      |...:|...::....:::||||. :..
Human   403 -RRHKKRTFLRPRIIGGSSSLPGSHPWLAAIY------IGDSFCAGSLVHTCWVVSAAHCFSHSP 460

  Fly  2598 PKGAYFVRVGDHYAN----IAESSEVDSFIENWYLHENFRKGTHMNNDIALVVLKTP----LKFS 2654
            |:.:..|.:|.|:.|    :.::..::.:|. :.|:..|....|   |:.|:.||..    ...|
Human   461 PRDSVSVVLGQHFFNRTTDVTQTFGIEKYIP-YTLYSVFNPSDH---DLVLIRLKKKGDRCATRS 521

  Fly  2655 DYVQPICLPDKNAELVEDRKCTISGWGSIKSGVSTPAQVLGSAELPILADHVCKQSNVYGSAMSE 2719
            .:|||||||:..:......||.|:|||.:...||..:..|..|.:|::|||.|....|||:.:|.
Human   522 QFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISP 586

  Fly  2720 GMFCAGSMDESVDACEGDSGGPLVCSDDDGETLYGLISWGQHCGFKNRPGVYVRVNHYIDWIYEK 2784
            .|.|||..|...|||:|||||||.|..:....|||:||||..||..::||||.||.:|:|||.::
Human   587 NMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDR 651

  Fly  2785 I 2785
            |
Human   652 I 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
teq	NP_648288.2	CBM_14	65..115	CDD:426342
		ChtBD2	136..184	CDD:214696
		ChtBD2	215..261	CDD:214696
		ChtBD2	284..327	CDD:214696
		ChtBD2	521..567	CDD:214696
		ChtBD2	608..654	CDD:214696
		ChtBD2	709..752	CDD:214696
		CBM_14	782..829	CDD:426342
		ChtBD2	864..909	CDD:214696
		CBM_14	942..993	CDD:426342
		Med15	1029..>1325	CDD:312941
		ChtBD2	1324..1369	CDD:214696
		ChtBD2	1474..1518	CDD:214696
		PHA03247	<1587..1906	CDD:223021
		LDLa	2193..2222	CDD:238060	2/30 (7%)
		SR	2229..2331	CDD:214555	20/113 (18%)
		LDLa	2337..2370	CDD:197566	8/40 (20%)
		SR	2382..2480	CDD:214555	27/121 (22%)
		Tryp_SPc	2547..2784	CDD:238113	88/245 (36%)
HGFAC	NP_001284368.1	PRK14954	<32..>100	CDD:184918	17/101 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..102		8/63 (13%)
		FN2	102..148	CDD:128373	10/54 (19%)
		EGF_CA	162..197	CDD:238011	9/45 (20%)
		FN1	200..240	CDD:238018	13/42 (31%)
		EGF_CA	245..278	CDD:238011	8/36 (22%)
		Kringle	286..367	CDD:395005	14/85 (16%)
		Tryp_SPc	415..650	CDD:238113	88/244 (36%)