DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment teq and SSC5D

DIOPT Version :9

Sequence 1:	NP_648288.2	Gene:	teq / 39048	FlyBaseID:	FBgn0023479	Length:	2792	Species:	Drosophila melanogaster
Sequence 2:	NP_001138422.1	Gene:	SSC5D / 284297	HGNCID:	26641	Length:	1573	Species:	Homo sapiens

Alignment Length:	710	Identity:	184/710 - (25%)
Similarity:	260/710 - (36%)	Gaps:	205/710 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2192 DFDCGNGQCLKKEEICD----GKKNCPNGKDEA-NCPPSDYEVRLSGGESPNMGRIEVKANGQWG 2251
            |..||.|:...::  |.    |:.||.:.:|.. .|......:||:.|.....||:||...|:||
Human   264 DVGCGGGEQALRD--CPRSPWGRSNCDHSEDAGLVCTGPAPRLRLADGPHGCAGRLEVWHGGRWG 326

  Fly  2252 YVCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGW 2316
            .||||.:.|:||.|.|||||.. ||....|.:|:...:...  ::|::.|.||||.|..|..:.|
Human   327 SVCDDAWDLRDAAVACRELGCG-GALAAPGGAFFGEGSGPI--ILDDLRCRGNETALRFCPARPW 388

  Fly  2317 GVHNCGVDEVAGVTCK-VPVMKCP-------NNYWLCHTSKECI--PPAFVCDNTPDCADKSDEC 2371
            |.|:|...|.||..|. :|:...|       ||    .|.:|..  ||:.:....|..|..|...
Human   389 GQHDCHHREDAGAVCDGMPLGYVPPTAPTDSNN----STPREAASRPPSTMTSQAPGTAGVSPPP 449

  Fly  2372 AA--VCQAP------VQYRLEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPA 2428
            |:  |...|      .|.||..|.:...|||||.|...||:||||.::::.:.|.|..:|..||.
Human   450 ASPTVLWEPGPEAGSPQLRLVAGPSKCSGRLEVWHDQRWGTVCDDSWDMRDSAVVCRELGCGGPQ 514

  Fly  2429 KIE--KNIFGNSNGPIWLDQVMCFGNETSIDQCNHWNWGEHNCNHTEDVALHCSAGPP---PRSQ 2488
            :.:  ...||...||||||.|.|.|.|.|:..|....||:|||.|.|||.:.|: |||   ..|.
Human   515 QPDPAAGRFGWGAGPIWLDDVGCVGTEASLSDCPAAPWGKHNCAHNEDVGVTCT-GPPGLDSISD 578

  Fly  2489 RYSQTQIKG-GRS---------------------LGRETT--------------------PKTYS 2511
            .:|.:.|.| ||.                     |.:.||                    |.|..
Human   579 PFSWSWIPGLGRDRDAWLPGELATKPSASVTASVLEKTTTKAPGKMPKSTKKWVTKNAKRPTTQP 643

  Fly  2512 QIGLWERSSKAVHTPRRCGIFKDDLTDEYAHREERVVRGNVAQRGRHPW---------------- 2560
            .:....:.|:|...|.........||.|.:.|................|
Human   644 PVMPTTKHSRAQSPPDLTSQTTAALTTEASRRPTSEFTRRPTTEAPQRWTSHTTATLTPQAPRER 708

  Fly  2561 ----QATIRTRGRGGISSHWCGAVV--ISKRHLLTAAHCLYGSPK-----------------GAY 2602
                .|.:.|:|...::|.   :.:  |.:..|..:|....|||:                 |.:
Human   709 TTKTMAMLTTQGPQEMTSE---STIKSIPQASLEPSAEIPEGSPESPKDPAPSPSVSTTGESGLF 770

  Fly  2603 FVRVGDHYANIAESSEVDSFIENWYLHENFRKGTHMNNDIALVVLKTPLKFSDYVQPICLPDKNA 2667
            .||:.|.....|...||      |:..   |.||                       :|  |.|.
Human   771 RVRLADGPNRCAGRLEV------WHAG---RWGT-----------------------VC--DDNW 801

  Fly  2668 ELVEDRKCTISGW----GSIKSGVSTPAQVLGSAELPILADHVCKQSNVYGSAMSEGMFCAGSMD 2728
            :|   |..|::.|    |.::..|.......|:.  ||..|               .|.|.|| :
Human   802 DL---RDATVACWELGCGKVRPRVGKTHYGPGTG--PIWLD---------------DMGCKGS-E 845

  Fly  2729 ESVDACEGDSGGPLVCSDDDGETLYGLISWGQH-CGFKNRPGV----YVRVNHYIDWIYE 2783
            .|:..|  .||                 :||:| |..:...|:    |...:.|..|.::
Human   846 ASLSDC--PSG-----------------AWGKHNCDHEEDVGLTCTGYTDYDDYPPWTWD 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
teq	NP_648288.2	CBM_14	65..115	CDD:279884
		ChtBD2	136..184	CDD:214696
		ChtBD2	215..261	CDD:214696
		ChtBD2	284..327	CDD:214696
		CBM_14	521..569	CDD:279884
		ChtBD2	608..654	CDD:214696
		ChtBD2	709..752	CDD:214696
		CBM_14	782..830	CDD:279884
		ChtBD2	864..909	CDD:214696
		CBM_14	942..993	CDD:279884
		RCR	<1051..1126	CDD:304939
		RCR	<1116..1210	CDD:304939
		ChtBD2	1324..1369	CDD:214696
		ChtBD2	1474..1518	CDD:214696
		LDLa	2193..2222	CDD:238060	8/33 (24%)
		SR	2229..2331	CDD:214555	42/101 (42%)
		SRCR	2234..2332	CDD:278931	40/97 (41%)
		LDLa	2337..2370	CDD:197566	10/41 (24%)
		SR	2382..2480	CDD:214555	43/99 (43%)
		SRCR	2386..2480	CDD:278931	41/95 (43%)
		Tryp_SPc	2546..2781	CDD:214473	50/282 (18%)
		Tryp_SPc	2547..2784	CDD:238113	51/285 (18%)
SSC5D	NP_001138422.1	SR	20..119	CDD:214555
		SRCR	25..120	CDD:278931
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..192
		SR	198..298	CDD:214555	9/35 (26%)
		SRCR	203..298	CDD:278931	9/35 (26%)
		SR	304..403	CDD:214555	42/101 (42%)
		SRCR	309..403	CDD:278931	40/96 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..465		13/56 (23%)
		SR	467..568	CDD:214555	43/100 (43%)
		SRCR	472..568	CDD:278931	41/95 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..769		22/157 (14%)
		SR	772..872	CDD:214555	36/173 (21%)
		SRCR	777..872	CDD:278931	33/168 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..1475
		SOBP	<1331..1479	CDD:291927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1554..1573
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D158600at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920