DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment teq and Prss12

DIOPT Version :9

Sequence 1:	NP_648288.2	Gene:	teq / 39048	FlyBaseID:	FBgn0023479	Length:	2792	Species:	Drosophila melanogaster
Sequence 2:	NP_032965.1	Gene:	Prss12 / 19142	MGIID:	1100881	Length:	761	Species:	Mus musculus

Alignment Length:	810	Identity:	244/810 - (30%)
Similarity:	341/810 - (42%)	Gaps:	215/810 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2111 DPFTE---HHPNSSPHQHHHHHRHPHEHSADFHIRHPELPN-PFPLKNETPQHQDL--------- 2162
            ||.:.   |.|:.||.:..|.|..|...      |.|..|. |.||:....|...:
Mouse    22 DPVSRSPLHRPHPSPPRSQHAHYLPSSR------RPPRTPRFPLPLRIPAAQRPQVLSTGHTPPT 80

  Fly  2163 -------NDDWDLLPNSNA-----EEVTPKL---------ATRSSFNTQCDFDCGNGQ--CLKKE 2204
                   .:.|....|...     :||.|.|         ..|...:..|....|:|:  |..:.
Mouse    81 IPRRCGAGESWGNATNLGVPCLHWDEVPPFLERSPPASWAELRGQPHNFCRSPDGSGRPWCFYRN 145

  Fly  2205 E-------ICDGKKNCPNGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGYVCDDKFGLKD 2262
            .       .||    |..|       |:...:||.||.|.:.||:|:...||||.:|||::...|
Mouse   146 AQGKVDWGYCD----CGQG-------PALPVIRLVGGNSGHEGRVELYHAGQWGTICDDQWDNAD 199

  Fly  2263 ADVVCRELGFQMGAQEVRGSSF---YAPPNQDFNYLMDEVECHGNETKLGQCAFKGWGVHNCGVD 2324
            |||:||:||....|:....:.|   ..|      .|:|||.|.|||..:.||....||.||||..
Mouse   200 ADVICRQLGLSGIAKAWHQAHFGEGSGP------ILLDEVRCTGNELSIEQCPKSSWGEHNCGHK 258

  Fly  2325 EVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDECAAVCQAPVQYRLEGGRNS 2389
            |.|||:| ||                      :.|..                   .||.||:::
Mouse   259 EDAGVSC-VP----------------------LTDGV-------------------IRLAGGKST 281

  Fly  2390 NEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAKIEKNIFGNSNGPIWLDQVMCFGNET 2454
            :||||||.:.|.||:||||.:...:..|||..:||....:...|.|..||.|||||.|.|.|.|.
Mouse   282 HEGRLEVYYKGQWGTVCDDGWTEMNTYVACRLLGFKYGKQSSVNHFDGSNRPIWLDDVSCSGKEV 346

  Fly  2455 SIDQCNHWNWGEHNCNHTEDVALHC---------SAGPPPR-----SQRYSQTQI----KGG--- 2498
            |..||:...||.|:|:|.|||.|.|         |.|.|.|     :::..:.::    :.|
Mouse   347 SFIQCSRRQWGRHDCSHREDVGLTCYPDSDGHRLSPGFPIRLVDGENKKEGRVEVFVNGQWGTIC 411

  Fly  2499 -------------RSLGRE--TTPKTYSQIGLWE-----------RSSKAV----------HTPR 2527
                         |.||.:  ...:|.:..|..:           .:.||:          |..|
Mouse   412 DDGWTDKHAAVICRQLGYKGPARARTMAYFGEGKGPIHMDNVKCTGNEKALADCVKQDIGRHNCR 476

  Fly  2528 R---CGIFKDDLTDEYA------------------HREERVVRGNVAQRGRHPWQATIRTRGRGG 2571
            .   .|:..|.|..:.:                  .|::|::.||.:.||..||||::|.|...|
Mouse   477 HSEDAGVICDYLEKKASSSGNKEMLSSGCGLRLLHRRQKRIIGGNNSLRGAWPWQASLRLRSAHG 541

  Fly  2572 ISSHWCGAVVISKRHLLTAAHCL--YGSPKGAYFVRVGDHYANIAESSEVDSFIENWYLHENFRK 2634
            .....|||.::|...:||||||.  ||:...:|.|||||::..:.|..|.:..::...:|.|:|.
Mouse   542 DGRLLCGATLLSSCWVLTAAHCFKRYGNNSRSYAVRVGDYHTLVPEEFEQEIGVQQIVIHRNYRP 606

  Fly  2635 GTHMNNDIALVVLKTP----LKFSDYVQPICL------PDKNAELVEDRKCTISGWGSIKSGVST 2689
             ...:.|||||.|:.|    .:.|.:|.|.||      |.|.|.     .|.|:|||......|
Mouse   607 -DRSDYDIALVRLQGPGEQCARLSTHVLPACLPLWRERPQKTAS-----NCHITGWGDTGRAYS- 664

  Fly  2690 PAQVLGSAELPILADHVCKQSNVYGSAMSEGMFCAGSM--DESVDACEGDSGGPLVC-SDDDGET 2751
              :.|..|.:|:|....||:.  |....:..|.|||::  |..||:|:|||||||:| ..|:...
Mouse   665 --RTLQQAAVPLLPKRFCKER--YKGLFTGRMLCAGNLQEDNRVDSCQGDSGGPLMCEKPDESWV 725

  Fly  2752 LYGLISWGQHCGFKNRPGVYVRVNHYIDWI 2781
            :||:.|||..||.|:.||||.||..::.||
Mouse   726 VYGVTSWGYGCGVKDTPGVYTRVPAFVPWI 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
teq	NP_648288.2	CBM_14	65..115	CDD:279884
		ChtBD2	136..184	CDD:214696
		ChtBD2	215..261	CDD:214696
		ChtBD2	284..327	CDD:214696
		CBM_14	521..569	CDD:279884
		ChtBD2	608..654	CDD:214696
		ChtBD2	709..752	CDD:214696
		CBM_14	782..830	CDD:279884
		ChtBD2	864..909	CDD:214696
		CBM_14	942..993	CDD:279884
		RCR	<1051..1126	CDD:304939
		RCR	<1116..1210	CDD:304939
		ChtBD2	1324..1369	CDD:214696
		ChtBD2	1474..1518	CDD:214696
		LDLa	2193..2222	CDD:238060	7/37 (19%)
		SR	2229..2331	CDD:214555	46/104 (44%)
		SRCR	2234..2332	CDD:278931	43/100 (43%)
		LDLa	2337..2370	CDD:197566	1/32 (3%)
		SR	2382..2480	CDD:214555	48/106 (45%)
		SRCR	2386..2480	CDD:278931	45/102 (44%)
		Tryp_SPc	2546..2781	CDD:214473	94/249 (38%)
		Tryp_SPc	2547..2784	CDD:238113	95/250 (38%)
Prss12	NP_032965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..87		14/67 (21%)
		KR	83..159	CDD:214527	14/79 (18%)
		SR	166..265	CDD:214555	46/104 (44%)
		SRCR	171..265	CDD:278931	43/99 (43%)
		SR	273..372	CDD:214555	47/98 (48%)
		SRCR	278..371	CDD:278931	44/92 (48%)
		SR	386..485	CDD:214555	12/98 (12%)
		SRCR	396..485	CDD:278931	11/88 (13%)
		Zymogen activation region	505..516		1/10 (10%)
		Tryp_SPc	516..755	CDD:214473	94/249 (38%)
		Tryp_SPc	517..758	CDD:238113	95/250 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	105	1.000	Domainoid score	I6638
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001772
OrthoInspector	1	1.000	-	-		oto93027
orthoMCL	1	0.900	-	-		OOG6_106745
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4992
SonicParanoid	1	1.000	-	-		X3236
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840