DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment teq and C39D10.7

DIOPT Version :9

Sequence 1:	NP_648288.2	Gene:	teq / 39048	FlyBaseID:	FBgn0023479	Length:	2792	Species:	Drosophila melanogaster
Sequence 2:	NP_509334.3	Gene:	C39D10.7 / 181050	WormBaseID:	WBGene00016534	Length:	1171	Species:	Caenorhabditis elegans

Alignment Length:	1312	Identity:	257/1312 - (19%)
Similarity:	416/1312 - (31%)	Gaps:	362/1312 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 PPHFTGLVAYPHDC-HRYVNCFDGSPTIQTCSPGTLFNDRTQVCD-HPSNVVCPSAESASTRLGR 128
            ||...|...|...| .:|:.|.:.....|:|..|..|:.....|: ..||.:|.:.:..:.   .
Worm    27 PPCPDGDGLYAVGCSSKYLQCVNNVEYEQSCPEGLYFDRLLARCERRSSNHLCATGDRVTL---N 88

  Fly   129 LRQLDSEPKCQPGVNGLQPHPSD---CSK-FLNCANGQAFIMDCAPGTAFSPASLVCVHKDLAKC 189
            :||......|...::|  .:..|   |:: :..||||.:::..|.....:.|.        |.:|
Worm    89 VRQKAVSINCVGRLSG--DYALDKTVCNENYYQCANGISYMRKCPYQQVYVPI--------LKRC 143

  Fly   190 GSGTGAVRDDTSGTGYPALPFDDLGCPPGTRGLRPHPHDVHKYLRCGIGVKPQVEQCPRGHIFDG 254
                                                  |.|.......|||.|.........:|
Worm   144 --------------------------------------DYHTNCNASGGVKDQAAAAYASPTYD- 169

  Fly   255 SSSVCVYSDSPRTSSSSFTSAEIQVNYLLCPVGAVGQFVHPFDQTK----FLSCKDGKSAVQNCQ 315
                   ||:...::..|.:..   |.|.|.|  .|. :|..|..|    |..|.:||...:.|.
Worm   170 -------SDNYIVTTKEFENGH---NGLDCKV--TGD-MHFTDNVKCSPYFWQCSNGKLFRKTCP 221

  Fly   316 PNYVFSISRRYCQLKAQL--------AFTDYVTLIISEISYEYSLILNACPGNINGIFLYPYDAK 372
            ...::.:.:..|.....:        :.|.|.....:..|..|..|..|           |.|..
Worm   222 EKLIYVLDQNLCDFPESVKDCPEYNGSETSYRAPKTTTSSSSYGSIAEA-----------PVDPT 275

  Fly   373 KYVQCSSGGRMSILSCGPQMAFSVSQRSCLPSHQVHISDRVQFWQEVQV-------QTTYTSQDL 430
            .|...|:.     :...|:..:.....|..|.:....:.....:...:.       .|...:..:
Worm   276 PYAPASAP-----VYSPPRTTYVPRSTSAAPPNPPPQNPTAAPYVPTEATPSPVFSSTVRYNPAV 335

  Fly   431 RGNVQSQ--LSSLRSCPPNVQKNYPYPFHAGHYVRCQYGALEIICCPTGQLYSLSQRQC------ 487
            .|:.:::  :..::.|            ||. ::.|..|...:|.|....::......|
Worm   336 HGDCKNRDGIFGIKEC------------HAS-FLSCDNGVGRVIQCADNLVFDTRVSACEFAAIC 387

  Fly   488 -VPRS-----LLSAHDYLDYSYISAELSTEFMVDRSTLSCPPQAQGLYLHPFDCTK-YVRCWNQQ 545
             .||.     :|..|... |:...||:..:|       .|..:..|.|:.. .||| :..|.:.:
Worm   388 LEPRKPEDVPVLYNHGGA-YNERPAEVKVDF-------DCTGKPNGKYIKE-ACTKSFFTCHDGR 443

  Fly   546 TFIESCTPGE-IFSFSNQKCVPKEQC-----------KG---PTDHVEY---LIETTT------- 585
            .|...| ||: :|:.:...|...|.|           ||   ||..:.|   ::.|||
Worm   444 AFANDC-PGDLVFNKATGTCDFAENCEKNYMEPSQIYKGEDTPTTTIGYSSSVVYTTTEQPATKP 507

  Fly   586 --------------------------------VTTYDSDGPESASSLAKTGDISCPPGASGNHAH 618
                                            ..||.:..|  .::.....|.||...|.||||.
Worm   508 YTQPPRDTERPSTIYGRPIYTKAPTTVGYEQPKATYTTQAP--VTTTIALDDFSCKHLADGNHAS 570

  Fly   619 PFDCTKFLECSNGQTFVKNCGPGTAFSTAKHICDHANQV-DCSGRN-------SLPEQSQVTQNN 675
            ....:.|..|:|||.....|.....|:.....||::..| ||.|..       |.|:.:......
Worm   571 GLCKSVFYICANGQVVATTCPANLIFNPYVGECDYSTNVRDCQGYQPTTTPSYSYPKTTSKPYEQ 635

  Fly   676 IATSYPTKPLDILPILKTSPPSYPHAEHLTDL------LCPSGVNGQFVHPFDQTKFLL-CQAGK 733
            .:|:....|::..|:.....|.|......|.|      :|....:|.:  .||..|:|: |...|
Worm   636 PSTTQGYAPIEYTPVTPGYAPQYTSTIFTTTLSPKYAAMCAKRDDGNY--GFDCEKYLIKCYNRK 698

  Fly   734 LAVQSCQSGYVFSISKSIC------------QPKTQ---------LVYSDYVTYKVSVISIDQTM 777
            .....|.||..:|..:..|            :|.|.         :.|.:| .|..|........
Worm   699 TFKFPCPSGLYYSRLQDKCDVKENVEGCPEYKPTTDATPAAEQPVISYQNY-GYSQSTTKAYNPS 762

  Fly   778 ILSACP----------DGTNGLHLYPYDAGKYVRCSDGGKMSIQSCENQMAFSLSQRAC------ 826
            :.:..|          :|..||....|    |:.|:: .:.:|..|...:.:|.....|
Worm   763 VTTPSPQHAAFCERLENGNYGLDCEDY----YISCNN-FETTINRCPAGLFYSKLNNRCDYKEHV 822

  Fly   827 --------RPSRLLSTEDRVRFREELQIQTTYSSQDIQ--------IQQSPLKE---CPSVLRGN 872
                    .||...:.|.....:     .|||:..:|.        :..:||.:   |.....|.
Worm   823 EDCPEYKPTPSTTPAAEQPGTTK-----YTTYNYPNIDYTSTTPGPVDTTPLAKAFSCSGRPDGI 882

  Fly   873 YPYPFHAGHFVNCQNGHLQIVSCPPTALYSLSQRECVVRQLLSPHDYLDYAYISVQLSTNIIHDT 937
            |..|:.:..:|.|..|...|.||.|...|:.....|..:..:..        ..:...::|| |:
Worm   883 YALPYCSQDYVQCMQGRSLISSCAPGLFYNEKNGMCAYKHTVDT--------CKIGKGSDII-DS 938

  Fly   938 TALSCPPQAQGYYLHPFDCTK-YIVCWEKQTHIESCPQGEAFSISQQKCV----ARD-KITQAYD 996
            .|  |..::.|||  ...|:. |..|.::|....|||....||...:|||    |:: .|....|
Worm   939 NA--CFGKSDGYY--SAGCSSYYFSCIDEQIRKMSCPNSLKFSKESEKCVFPIDAKECSIATTLD 999

  Fly   997 RV------EYLEDTQHELSHEEAEEEEQTEPESNLSLDGGNQPPGKYQAPYYSNGGYPTPSQNNG 1055
            |.      ::.....:.|.|     .:...|. .:..|.|....|...||...||...|.:
Worm  1000 RTPPAVPSDFCTIRSNGLHH-----LKMCSPH-YIVCDNGRAFSGTCIAPLVYNGDTQTCN---- 1054

  Fly  1056 GYQTPSQNNGGYQAPFQNNGGYQPSYQGNGGYTPTYQNPFEGYHQPNQSSYQTNGGYQPPLPPHG 1120
             |::.:::.|....|        |..:....|| ||..  :.:.||..::  |...|||.....|
Worm  1055 -YKSTNKDCGNDYIP--------PVAEVTSSYT-TYTT--KRFEQPAPTT--TAAPYQPQTTTTG 1105

  Fly  1121 -------------GYQPPSQTYGGFQQPNRTYEDFHNPSQTVGGFQPPYSVKGGYQ-PHNQLNGG 1171
                         .|:.|:.|      |:|   |...|:.|.   ..||......| ........
Worm  1106 KVLYKAAYTTTATQYEEPATT------PSR---DVETPTTTT---HKPYETTTEAQDATTTTTAS 1158

  Fly  1172 YNQPNQSSSFQA 1183
            |..|..||::::
Worm  1159 YVAPTTSSAYKS 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
teq	NP_648288.2	CBM_14	65..115	CDD:279884	14/50 (28%)
		ChtBD2	136..184	CDD:214696	10/51 (20%)
		ChtBD2	215..261	CDD:214696	7/45 (16%)
		ChtBD2	284..327	CDD:214696	11/46 (24%)
		CBM_14	521..569	CDD:279884	13/49 (27%)
		ChtBD2	608..654	CDD:214696	15/45 (33%)
		ChtBD2	709..752	CDD:214696	12/43 (28%)
		CBM_14	782..830	CDD:279884	12/71 (17%)
		ChtBD2	864..909	CDD:214696	12/47 (26%)
		CBM_14	942..993	CDD:279884	18/56 (32%)
		RCR	<1051..1126	CDD:304939	16/87 (18%)
		RCR	<1116..1210	CDD:304939	16/82 (20%)
		ChtBD2	1324..1369	CDD:214696
		ChtBD2	1474..1518	CDD:214696
		LDLa	2193..2222	CDD:238060
		SR	2229..2331	CDD:214555
		SRCR	2234..2332	CDD:278931
		LDLa	2337..2370	CDD:197566
		SR	2382..2480	CDD:214555
		SRCR	2386..2480	CDD:278931
		Tryp_SPc	2546..2781	CDD:214473
		Tryp_SPc	2547..2784	CDD:238113
C39D10.7	NP_509334.3	CBM_14	29..79	CDD:279884	12/49 (24%)
		CBM_14	98..148	CDD:279884	14/97 (14%)
		CBM_14	189..242	CDD:279884	12/55 (22%)
		ChtBD2	337..384	CDD:214696	9/59 (15%)
		CBM_14	419..467	CDD:279884	13/49 (27%)
		CBM_14	560..612	CDD:279884	16/51 (31%)
		CBM_14	675..726	CDD:279884	13/52 (25%)
		CBM_14	774..825	CDD:279884	10/55 (18%)
		CBM_14	875..927	CDD:279884	13/59 (22%)
		CBM_14	941..992	CDD:279884	17/52 (33%)
		CBM_14	1010..1062	CDD:279884	12/62 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910