DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment teq and prss12

DIOPT Version :9

Sequence 1:	NP_648288.2	Gene:	teq / 39048	FlyBaseID:	FBgn0023479	Length:	2792	Species:	Drosophila melanogaster
Sequence 2:	XP_002934300.3	Gene:	prss12 / 100495119	XenbaseID:	XB-GENE-984837	Length:	851	Species:	Xenopus tropicalis

Alignment Length:	888	Identity:	253/888 - (28%)
Similarity:	355/888 - (39%)	Gaps:	270/888 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  2102 YHRRHP----NLPDPFTEHHPNSSPHQHHHHHR----------------HPHEHSADFHIRHPEL 2146
            |||.|.    :||.|.:::|....|...|.||.                :..|..||. :...|:
Frog    30 YHRIHHQQSLHLPLPTSQNHQPHHPLPAHGHHTGCPKYAGKSGSIGDFVNVTEFGADC-LNWVEV 93

  Fly  2147 PNPFPLKNETPQHQDLND------------------------DWDLL-----------PNSNAEE 2176
            |.   ....|| .:.|.|                        ||...           ..|.:|.
Frog    94 PT---FLERTP-GKGLGDHNFCRNPDGRSKPWCFFRNNHGRIDWGYCDCKQGSVRLRGSKSKSEG 154

  Fly  2177 VTPKLATRSSFNTQC-----DFDC---------------------GNG---------QCLKKEE- 2205
            ...::....::.|.|     |.|.                     |.|         ||...||
Frog   155 SVVEVYVNGAWGTICSGQWDDNDASVICRQLELGDKGTAKKIVLSGVGQISAFWTDVQCRGNEEN 219

  Fly  2206 ICDGKKN------CP------------NGKDEANCPPSDYEVRLSGGESPNMGRIEVKANGQWGY 2252
            |....|:      ||            ..||....|     .||.||.||..|||||..:|.||.
Frog   220 ILQCAKDIWRSGACPQDTAAAITCSVIQAKDSVFIP-----ARLVGGSSPYEGRIEVYHSGHWGT 279

  Fly  2253 VCDDKFGLKDADVVCRELGFQMGAQEVRGSSFYAPPNQDFNYLMDEVECHGNETKLGQCAFKGWG 2317
            ||||::...||:||||:||:  |......|..:......| .|:|||:|.|||..:.:|....||
Frog   280 VCDDQWDDADAEVVCRQLGY--GGVAKAWSQAHFGEGVGF-ILLDEVQCTGNELSIEECQRSPWG 341

  Fly  2318 VHNCGVDEVAGVTCKVPVMKCPNNYWLCHTSKECIPPAFVCDNTPDCADKSDECAAVCQAPVQYR 2382
            .||||..|.|||:|                             || .||.:            .|
Frog   342 EHNCGHKEDAGVSC-----------------------------TP-LADGA------------IR 364

  Fly  2383 LEGGRNSNEGRLEVKHHGVWGSVCDDDFNLKSAQVACNSMGFFGPAKIEKNIFGNSNGPIWLDQV 2447
            |.||:.|:||||||.|...||:||||.:...:.||.|..:|:.....:.:|.:..|.|.||||.:
Frog   365 LAGGKGSHEGRLEVFHKARWGTVCDDGWTDLNTQVVCRQLGYKNGKILLENHYAGSAGVIWLDDI 429

  Fly  2448 MCFGNETSIDQCNHWNWGEHNCNHTEDVALHCS---------AGPPPR-----SQRYSQTQI--- 2495
            .|.|.|:.|.||:..:||:|:|:|.|||.:.|.         :|||.|     :::..:.:|
Frog   430 SCTGKESMISQCSRRDWGKHDCSHQEDVHIACHPDNETHRPLSGPPLRLMDGETKKEGRVEIYLN 494

  Fly  2496 -KGGRSLGRETTPKTYS----QIGLWERSSKA------------VHTPR-RCGIFKDDLTD---- 2538
             :.|.......|.|..|    |:| ::..:||            :|... ||..::..|.|
Frog   495 GQWGTICDDGWTDKDASVVCRQLG-YKGPAKARTMAYFGEGKGPIHVDNVRCTGYERSLADCIKQ 558

  Fly  2539 -----------------EYA-----------------------HREERVVRGNVAQRGRHPWQAT 2563
                             :|.                       .|.:|::.|..:.||..|||..
Frog   559 DIGTHNCRHSEDAGVICDYIIKKSTFAANKELSPLVCGSRLQHRRPKRIIGGKNSVRGGWPWQVA 623

  Fly  2564 IRTRGRGGISSHWCGAVVISKRHLLTAAHCL--YGSPKGAYFVRVGDHYANIAESSEVDSFIENW 2626
            :|.:...|.....|||.:||...:||||||.  ||:...:|.:||||::..:.|..|.|..|:..
Frog   624 LRLKSSHGDGRLLCGATLISSCWVLTAAHCFKRYGNNTRSYVIRVGDYHTLVPEEYEEDMTIQQI 688

  Fly  2627 YLHENFRKGTHMNNDIALVVL----KTPLKFSDYVQPICL------PDKNAELVEDRKCTISGWG 2681
            .:|.::|...: :.||||:.|    :..::.|.:|.|.||      |.|.|.     .|.|:|||
Frog   689 IIHNDYRPDGN-DYDIALIRLHGTAEQCVQLSTHVLPACLPLRRERPQKTAS-----NCYITGWG 747

  Fly  2682 SIKSGVSTPAQVLGSAELPILADHVCKQSNVYGSAMSEGMFCAGSM--DESVDACEGDSGGPLVC 2744
            ......|   :.|..|.:.:|...||::.  |.|..:..|.||||:  .:.||:|:|||||||||
Frog   748 DTGRAYS---RTLQQATVTLLPKRVCEER--YRSQFTGRMLCAGSVKTQKHVDSCQGDSGGPLVC 807

  Fly  2745 SDDDGE-TLYGLISWGQHCGFKNRPGVYVRVNHYIDWIYEKIN 2786
            ....|. .:||:.|||..||.|:.||||.:|:.:|.||....|
Frog   808 ERSGGSWIVYGVTSWGYGCGVKDSPGVYTKVSAFIPWIKSVTN 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
teq	NP_648288.2	CBM_14	65..115	CDD:279884
		ChtBD2	136..184	CDD:214696
		ChtBD2	215..261	CDD:214696
		ChtBD2	284..327	CDD:214696
		CBM_14	521..569	CDD:279884
		ChtBD2	608..654	CDD:214696
		ChtBD2	709..752	CDD:214696
		CBM_14	782..830	CDD:279884
		ChtBD2	864..909	CDD:214696
		CBM_14	942..993	CDD:279884
		RCR	<1051..1126	CDD:304939
		RCR	<1116..1210	CDD:304939
		ChtBD2	1324..1369	CDD:214696
		ChtBD2	1474..1518	CDD:214696
		LDLa	2193..2222	CDD:238060	13/77 (17%)
		SR	2229..2331	CDD:214555	48/101 (48%)
		SRCR	2234..2332	CDD:278931	45/97 (46%)
		LDLa	2337..2370	CDD:197566	4/32 (13%)
		SR	2382..2480	CDD:214555	43/97 (44%)
		SRCR	2386..2480	CDD:278931	40/93 (43%)
		Tryp_SPc	2546..2781	CDD:214473	91/249 (37%)
		Tryp_SPc	2547..2784	CDD:238113	92/251 (37%)
prss12	XP_002934300.3	KR	78..140	CDD:412161	11/66 (17%)
		SRCR	148..244	CDD:395421	16/95 (17%)
		SR	257..356	CDD:214555	49/130 (38%)
		SR	363..461	CDD:214555	43/97 (44%)
		SR	476..575	CDD:214555	15/99 (15%)
		Tryp_SPc	607..848	CDD:238113	92/251 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D158600at2759
OrthoFinder	1	1.000	-	-		FOG0001772
OrthoInspector	1	1.000	-	-		otm48213
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4992
SonicParanoid	1	1.000	-	-		X3236
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950