DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OR4Q2 and 5-HT2B

DIOPT Version :9

Sequence 1:	NP_001335200.1	Gene:	OR4Q2 / 390432	HGNCID:	15359	Length:	313	Species:	Homo sapiens
Sequence 2:	NP_001262373.1	Gene:	5-HT2B / 41017	FlyBaseID:	FBgn0261929	Length:	947	Species:	Drosophila melanogaster

Alignment Length:	230	Identity:	48/230 - (20%)
Similarity:	95/230 - (41%)	Gaps:	51/230 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    29 VLFLFFYMSIWVGNVLIMVTVASDKYLNSSPMYFLLGNLSFLDLCYSTVTTP----KLLADFFNH 89
            :|.|...:....||:|:.:.:|.::.|.:...|||: :|:..||..:.:..|    .|:..:|.
  Fly    78 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLM-SLAITDLMVAVLVMPLGILTLVKGYFP- 140

Human    90 EKLISYDQCIVQLFF-LHFVGAAEMFLLTVMAYDRYVAICRPLHYTTVMSQGLCCVLVAASWMGG 153
               :..:.|:..:.. :.|..|:.|.|.|: :.|||:::..|:.:....::....:.:...|:
  Fly   141 ---LGSEHCLTWICLDVLFCTASIMHLCTI-SVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWL-- 199

Human   154 FVHSTVQTILTVHLPFC---GPNQVE---NFFCDVP-PVIKL----ACADTFVIELLMVSNSGLI 207
                   ..:.:.||..   ..|...   |..|.:| ||.||    .|   |.|.|
  Fly   200 -------LSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVC---FYIPL--------- 245

Human   208 STISFVVLISSYTTILVKIRSKE----GRRKALST 238
                .|:|::...|:.:..|.::    |::.|.:|
  Fly   246 ----GVMLLTYCLTVRLLARQRQNLGGGQQTAAAT 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OR4Q2	NP_001335200.1	7tmA_OR4Q2-like	25..290	CDD:320604	48/230 (21%)
		TM helix 1	26..52	CDD:320604	6/22 (27%)
		TM helix 2	60..86	CDD:320604	8/29 (28%)
		TM helix 3	98..128	CDD:320604	9/30 (30%)
		TM helix 4	141..162	CDD:320604	1/20 (5%)
		TM helix 5	196..226	CDD:320604	5/29 (17%)
		TM helix 6	230..260	CDD:320604	3/13 (23%)
		TM helix 7	265..290	CDD:320604
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	42/202 (21%)
5-HT2B	NP_001262373.1	7tm_4	90..>238	CDD:304433	35/162 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910