DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4911 and fbxl3l

DIOPT Version :9

Sequence 1:NP_001286990.1 Gene:CG4911 / 39043 FlyBaseID:FBgn0035959 Length:450 Species:Drosophila melanogaster
Sequence 2:XP_693270.2 Gene:fbxl3l / 564855 ZFINID:ZDB-GENE-130530-598 Length:448 Species:Danio rerio


Alignment Length:501 Identity:110/501 - (21%)
Similarity:174/501 - (34%) Gaps:177/501 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 NFSQRQPE-WHRIPSVALNHIFDYLNPQDRRSAAGVCFSWRHALFQKRYFRNFRFQLDVGCDDQL 65
            ||.....| |..:|...:.|||.||:..||..|:.||..|.........:|.|.|:|:......|
Zfish    47 NFQNATEETWGNLPHHVVLHIFQYLSLVDRARASSVCRRWNEVFHIPDLWRRFEFELNQPATSYL 111

  Fly    66 AFFHRSMANLAMELIVVFDFQNAVHIQKMRGLLYKVAHCD-------NI--QKLRFQTHNVGLVA 121
            ...|   .:|..::|       ..|.|.::.:.:||..|.       ||  |.:......:||::
Zfish   112 RSTH---PDLIQQII-------KRHAQHLQYVSFKVDSCTESAEAACNILSQLVNCTIKTLGLIS 166

  Fly   122 IG-----NMHSEHLLAIEQCFVEPL-ILFLSRKRQPCQLLDLGAIEALSYYGHDFLKAMGKPQEL 180
            ..     ::...|       ||..| ::|::.|                                
Zfish   167 TARPSFMDVSQSH-------FVSALTVVFVNSK-------------------------------- 192

  Fly   181 LQLTLASIKY------DPSHYPILSLDSTLLQ--------------------KCAALQVLSLDYD 219
               :|:|||.      |||...:::.:|..|:                    :|..|:.|:|:|.
Zfish   193 ---SLSSIKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYH 254

  Fly   220 TLSDELLHTI---QVLPLRKLLIAVHGLDSEEHP------DVSETAWSNFSDHFSSIELVLTLVY 275
            .||||||..:   :.:.|..|.|.|    ..|:|      .:.:::|.....|...:.:|: ..:
Zfish   255 LLSDELLLALSSEKHVHLEHLRIDV----VSENPGQTQFHTIKKSSWDALIRHSPQVNIVM-YFF 314

  Fly   276 AYEAIALLQHRVLRSNMPVTHVRLLFCEKMNAEALDWMSLHYRETLRSIHYVDAPYKYSNRMNSS 340
            .||...   ....|...||||  |.|...::.:.|..:.|                      |..
Zfish   315 LYEEEF---EPFFREETPVTH--LYFGRAVSKDMLGRIGL----------------------NCP 352

  Fly   341 RRVSL---------LQDPFVMMAWRCKQLE-------EIVVHGYLMDPHNLVGIARLRGRQLKRL 389
            |.|.|         |.:..:.:|.|||.|.       |:...|::       ...::.|.:|.:|
Zfish   353 RLVELVVCANGLEPLDEELIRIADRCKSLTAIGLGECEVTCSGFM-------EFVKMCGGRLSQL 410

  Fly   390 ----EVSMIDWSGAPLLNAYN-----EEISTLLGQQWSPISFDKMP 426
                ||.:.|       |.||     .|:|..||:.|.|   |.||
Zfish   411 SIMEEVLIPD-------NTYNIEQIHSEVSKHLGRIWFP---DMMP 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4911NP_001286990.1 F-box 8..53 CDD:279040 15/45 (33%)
fbxl3lXP_693270.2 F-box-like 56..99 CDD:289689 14/42 (33%)
leucine-rich repeat 194..218 CDD:275381 7/23 (30%)
leucine-rich repeat 220..245 CDD:275381 2/24 (8%)
leucine-rich repeat 246..271 CDD:275381 10/24 (42%)
leucine-rich repeat 272..306 CDD:275381 8/37 (22%)
leucine-rich repeat 307..353 CDD:275381 13/73 (18%)
AMN1 <347..>412 CDD:187754 16/93 (17%)
leucine-rich repeat 354..380 CDD:275381 6/25 (24%)
leucine-rich repeat 381..403 CDD:275381 3/28 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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