Protein Alignment CG4911 and FBXO33

DIOPT Version :9

• Sequence 1: NP_001286990.1
• Gene: CG4911 / 39043
• FlyBaseID: FBgn0035959
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_976046.1
• Gene: FBXO33 / 254170
• HGNCID: 19833
• Length: 555
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 115/502 - (22%)
• Similarity: 195/502 - (38%)
• Gaps: 138/502 - (27%)

  Fly    13 IPSVALNHIFDYLNPQDRRSAAGVCFSWRHALFQKRYFRNFRFQLDVGCDDQ--LAFFHRSMANL 75
            :||..:.|||.:|...||..|:..|..||..||....:...|..|.|...:|  |.|..|.....
Human    71 LPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWF 135

  Fly    76 AMELIVVFDFQN-----------------------------------AVHIQKMRGLLYKVAHCD 105
            ..||.|.|..:|                                   ..:::.:..:|..:.:..
Human   136 VRELRVEFAAENYLSGGGPGDGGGADTGTGGEEVEALQLSARWLEVLRTYLELVLCVLVSIRNNR 200

  Fly   106 NIQKLRFQTHNVGLVAI----GNMHSEHL----------LAIEQCFVEPLILFLSRKRQPCQLLD 156
            |:||...    .|.:::    |::.:.:|          ..|:|.|.|    .||..||
Human   201 NLQKFSL----FGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQLFEE----ILSNSRQ------ 251

  Fly   157 LGAIEALSYYGHDFLKAMGKPQELLQLTLASIKYDPSHYPILSL----DSTL-----LQKCAALQ 212
                  |.:....|:..:..|..|..|:.| :.....|..:|..    :|||     |::...|.
Human   252 ------LKWLSCGFMLEIVTPTSLSSLSNA-VANTMEHLSLLDNNIPGNSTLITAVELERFVNLH 309

  Fly   213 VLSLDYDTLSDELLHTI---QVLPLRKLLIAVH----------GLDSEEHPDVSETAWSNFSDHF 264
            .|:||:...:.|:...:   ..:||::|.:.||          .:.::||       |...|...
Human   310 SLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNVSVMHKSLDNMPNDEH-------WKALSRKS 367

  Fly   265 SSIELVLTLVYAYEAIALLQHRVLRSNMPVTHVRL---LFCEKMNAEALDWMSLHYRETLRSIHY 326
            :|..:   .:.|::..:....::|:.::|:..:..   :.|  ::...:|.:|..|.:.|  .|:
Human   368 TSFRV---YIMAFDIKSEDMLKILKPSIPLERIHFDSYITC--VSGAIVDLISRQYDKFL--THF 425

  Fly   327 V---------DAPYKYSNRMNSSRRVSLLQDPFVMMAWRCKQLEEIVVHGYLMDPHNLVGIARLR 382
            :         ..|....||.         :||.|::||||.:|..:.:|||.:..|||:.|||||
Human   426 ILMNDVIDTSGFPDLSDNRN---------EDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLR 481

  Fly   383 GRQLKRLEVS--MIDWSGAPLLN-----AYN--EEISTLLGQQWSPI 420
            |..||.|||:  .||:....|.:     .:|  |::|..|||.|..:
Human   482 GSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGQPWHAV 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4911	NP_001286990.1	F-box	8..53	CDD:279040	14/39 (36%)
FBXO33	NP_976046.1	F-box-like	69..116	CDD:289689	15/44 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147922
Domainoid	1	1.000	69	1.000	Domainoid score	I9665
eggNOG	1	0.900	-	-		E1_2CMAU
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I5233
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47170
OrthoDB	1	1.010	-	-		D215358at33208
OrthoFinder	1	1.000	-	-		FOG0007383
OrthoInspector	1	1.000	-	-		oto90143
orthoMCL	1	0.900	-	-		OOG6_108362
Panther	1	1.100	-	-	LDO	PTHR20933
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8386
SonicParanoid	1	1.000	-	-		X5507
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800