DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4911 and fbxl8

DIOPT Version :9

Sequence 1:	NP_001286990.1	Gene:	CG4911 / 39043	FlyBaseID:	FBgn0035959	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_012816105.1	Gene:	fbxl8 / 100158652	XenbaseID:	XB-GENE-1012778	Length:	373	Species:	Xenopus tropicalis

Alignment Length:	398	Identity:	86/398 - (21%)
Similarity:	149/398 - (37%)	Gaps:	105/398 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WHRIPSVALNHIFDYLNPQDRRSAAGVCFSWRHALFQKR--YFRNFRFQLD------------VG 60
            |..:|...|..||.:|:..||...:.||..|..|:....  ::...|...|            ||
Frog     5 WKHMPQEILAIIFYHLSLNDRFVVSQVCQLWAIAMASSPVWHYTEIRLVSDKDLLLLEGLRQYVG 69

  Fly    61 CDDQLAF-FHRSMANLAMELIVVFDFQNAVHIQKMRGLLYKVAHCDNIQKLRFQTHNVGLVAIGN 124
            ....|.. |::|.....|::|.:||                 ..|....||    .::.:|..|.
Frog    70 QIKHLKLVFNQSKETNRMKVIEIFD-----------------CLCKESCKL----ESLNIVCCGE 113

  Fly   125 ---MHS--EHLLAIEQ-CFVEPLIL-FLSRKRQPCQLLDLGAIEALSYYGHDFLKAMGKPQELL- 181
               .:|  |.|.:|.. |...|:.| .:..:..|..|.|            ||::.:......|
Frog   114 NPFFYSGPEILTSIANLCRDSPIDLHHVDFRNVPFTLTD------------DFVRCIATSSPNLR 166

  Fly   182 -----------QLTLASIKYDPSHYPILSLDSTLLQKCAALQVLSLDYDTLSDELLHTIQV---L 232
                       :::.::||             .:|:.|..|.||...|.:|::::...|..   .
Frog   167 SLYINNGTLVCKISTSAIK-------------EVLEVCPKLCVLGAFYCSLNEDVFKDIMKPHRP 218

  Fly   233 PLRKLLIAVHGLDSEEH-PDVSETAWSNFSDHFSSIELVLTLVYAYEAIALLQHRVLRSNMPVTH 296
            |...|.:....:|  :| ..:|:..|.:......|:.:.:...:...| ..:.| :|:.::||..
Frog   219 PFNCLDLFCERMD--KHILAISDEVWRDLRCRHPSLHVNMAFDHTIPA-RKIPH-ILKPSIPVDT 279

  Fly   297 VRL-LFCEKMNAEALDWMSLHYRETLRSIHYVDAPYKYSNRMNSSRRVSLLQDPFVMMAWRCKQL 360
            ::| .|.|.||  .:.::|.||.:||:         |:..:..||   |.|....:.:|.:|.:|
Frog   280 LQLNTFNEMMN--EIRFVSSHYSQTLQ---------KFVIQTTSS---SELDSALIDLAGKCSRL 330

  Fly   361 EEIVVHGY 368
            ||  ||.|
Frog   331 EE--VHCY 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4911	NP_001286990.1	F-box	8..53	CDD:279040	12/44 (27%)
fbxl8	XP_012816105.1	F-box	5..47	CDD:395521	12/41 (29%)
		leucine-rich repeat	103..133	CDD:275381	8/33 (24%)
		leucine-rich repeat	138..164	CDD:275381	6/37 (16%)
		leucine-rich repeat	165..193	CDD:275381	5/40 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910